A hTfR1 Receptor-Specific VHH Antibody Neutralizes Pseudoviruses Expressing Glycoproteins from Junín and Machupo Viruses [PDF]
VirusesThe Junín virus (JUNV) is one of the New World arenaviruses that cause severe hemorrhagic fever. Human transferrin receptor 1 (hTfR1) has been identified as the main receptor for JUNV for virus entry into host cells.
Qinglin Kang +13 more
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Recent Discoveries of Novel Mammarenaviruses Infecting Humans and Other Mammals in Asia and Southeast Asia [PDF]
Virulence, 2023 Mammarenaviruses, a genus of the family Arenaviridae, are capable of infecting mammals and are primarily found in rodent reservoirs worldwide. Mammarenaviruses can be transmitted to humans through contact with infected rodents, and though infection is ...
Brigitte Flannery +2 more
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In situ insights into antibody-mediated neutralization of a pre-fusion Junin virus glycoprotein complex [PDF]
Cell ReportsSummary: A transmembrane glycoprotein complex (GPC) decorates the Junin mammarenavirus (JUNV) that causes New World hemorrhagic fevers. We leveraged single-particle cryoelectron microscopy (cryo-EM) to image the full-length JUNV GPC directly on ...
Lily J. Taylor +10 more
doaj +2 more sources
Animal Models of Pathogenic New World Arenaviruses [PDF]
MicroorganismsSince the emergence of Junín virus in 1953, pathogenic New World arenaviruses have remained a public health concern. These viruses, which also include Machupo virus, Guanarito virus, Sabiá virus, and Chapare virus, cause acute viral hemorrhagic fever and
Alexander V. Alvarado +3 more
doaj +2 more sources
A review of emerging health threats from zoonotic New World mammarenaviruses [PDF]
BMC MicrobiologyDespite repeated spillover transmission and their potential to cause significant morbidity and mortality in human hosts, the New World mammarenaviruses remain largely understudied.
Arianna Lendino +3 more
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Bovine Serum Albumin Nanoparticle-Mediated Delivery of Ribavirin and Mycophenolic Acid for Enhanced Antiviral Therapeutics [PDF]
VirusesThe global spread of viral diseases is a public health issue. Ribavirin (RBV) and mycophenolic acid (MPA) are well-known wide-spectrum antiviral agents.
Mayra A. Castañeda Cataña +7 more
doaj +2 more sources
Vaccine Candidates against Arenavirus Infections
Vaccines, 2023 The viral family Arenaviridae contains several members that cause severe, and often lethal, diseases in humans. Several highly pathogenic arenaviruses are classified as Risk Group 4 agents and must be handled in the highest biological containment ...
Takeshi Saito +5 more
doaj +1 more source
Junin virus structural proteins [PDF]
Journal of Virology, 1977 Polyacrylamide gel electrophoresis of purified Junin virus revealed six distinct structural polypeptides, two major and four minor ones. Four of these polypeptides appeared to be covalently linked with carbohydrate. The molecular weights of the six proteins, estimated by coelectrophoresis with marker proteins, ranged from 25,000 to 91,000.
Z M, De Martínez Segovia, M I, De Mitri
openaire +2 more sources
Junin Virus Activates p38 MAPK and HSP27 Upon Entry
Frontiers in Cellular and Infection Microbiology, 2022 Junín virus (JUNV), a New World arenavirus, is a rodent-borne virus and the causative agent of Argentine hemorrhagic fever. Humans become infected through exposure to rodent host secreta and excreta and the resulting infection can lead to an acute ...
Collin J. Fitzpatrick +11 more
doaj +1 more source
The roles of XJ13 and XJ44-specific mutations within the Candid #1 GPC in Junin virus attenuation
Frontiers in Immunology, 2023 Junin virus (JUNV) is a member of the Arenaviridae family of viruses and is the pathogen responsible for causing Argentine hemorrhagic fever, a potentially lethal disease endemic to Argentina.
John Tyler Manning +8 more
doaj +1 more source