Results 51 to 60 of about 119,689 (246)

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

Advanced Science, EarlyView.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu, Yawei Shen, Robert J. Barndt, Karim Sallam, Ying Tang, Cameron E. Brown, Xiao Li, Stephen Y. Chan, Joseph C. Wu, Qing Liu, Haodi Wu   +10 more
wiley   +1 more source

Characterization of Vitamin B12 Supplementation and Correlation with Clinical Outcomes in a Large Longitudinal Study of Early Parkinson's Disease. [PDF]

, 2019
ObjectiveIn Parkinson's disease (PD), vitamin B12 levels are lower, and comorbid B12 deficiency has been associated with the development of neuropathy and early gait instability.
Christine, Chadwick W, Dietiker, Cameron, Kim, Soeun, Zhang, Yunxi   +3 more
core  

Association of vitamin B12 with pro-inflammatory cytokines and biochemical markers related to cardiometabolic risk in Saudi subjects [PDF]

, 2016
Background: This study aimed to examine the relationship between changes in systemic vitamin B12 concentrations with pro-inflammatory cytokines, anthropometric factors and biochemical markers of cardiometabolic risk in a Saudi population.
Al-Attas, O.S., Al-Attas, O.S., Al-Daghri, N.M., Al-Daghri, N.M., Alokail, M.S., Alokail, M.S., McTernan, P.G., McTernan, P.G., Rahman, S., Rahman, S., Sabico, S., Sabico, S., Saravanan, P., Saravanan, P., Tripathi, G., Tripathi, G., Wani, K., Wani, K., Yakout, S., Yakout, S.   +19 more
core   +3 more sources

Nanomedicines Against Mitochondrial Dysfunction‐Induced Metabolic Diseases

Advanced Science, EarlyView.
Mitochondrial dysfunction is central to metabolic diseases. Nanomedicine offers transformative approaches for restoring function via targeted delivery, responsive release, and multimodal therapy. This review outlines the pathological basis, nanocarrier design, organelle‐specific targeting, recent advances, and future clinical translation challenges ...
Ke Xu, Leyi Wang, Tao Lv, Chen Jin, Qiong Wu, Yongjie Zhou, Gang Xu, Zhenyu Duan, Kui Luo, Jiayin Yang   +9 more
wiley   +1 more source

Vitamin B12 Intake From Animal Foods, Biomarkers, and Health Aspects

Frontiers in Nutrition, 2019
The EAT-Lancet commission recently suggested that transformation to healthy diets by 2050 will require a reduction of at least 50% in consumption of foods such as red meat and sugar, and a doubling in the global consumption of fruits, vegetables, nuts ...
Rima Obeid, Sandra G. Heil, Maxime M. A. Verhoeven, Ellen G. H. M. van den Heuvel, Lisette C. P. G. M. de Groot, Simone J. P. M. Eussen   +5 more
doaj   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

The status of vitamin B12 and folate among Chinese women: a population-based cross-sectional study in northwest China. [PDF]

PLoS ONE, 2014
OBJECTIVE: To assess the status of the vitamin B12 and folate of Chinese women living in northwest China. METHODS: A population-based cross-sectional study was conducted in 2008 among Chinese women aged 10-49 years living in Shaanxi province of northwest
Shaonong Dang, Hong Yan, Lingxia Zeng, Quanli Wang, Qiang Li, Shengbin Xiao, Xiaojing Fan   +6 more
doaj   +1 more source

Vitamin B12 deficiency common in primary hypothyroidism [PDF]

, 2008
OBJECTIVE: To assess the prevalence and clinical features of B12 deficiency in hypothyroid patients and to evaluate clinical response in symptoms to B12 replacement therapy.
Akhter, J., Islam, Najmul, Jabbar, Abdul, Khan, Ataullah, Ul Haque, Naeem, Waseem, Sabiha, Yawar, Aasma, Zuberi, Lubna   +7 more
core   +1 more source

Vitamin B12 status in patients of Turkish and Dutch descent with depression: A comparative cross-sectional study [PDF]

, 2009
Background: Studies have shown a clear relationship between depressive disorders and vitamin B12 deficiency. Gastroenteritis and Helicobacter pylori infections can cause vitamin B12 deficiency. Helicobacter pylori infections are not uncommon among people
A Coppen, A Hvas, AC Vries de, AH Ford, AT Beck, B Spitzer, BR Hutto, BW Penninx, CR Santhosh-Kumar, D Mischoulon, DF Horrobin, E Serin, G Parker, H Tiemeier, HG Ruhe, J Hintikka, J Lindenbaum, J Selhub, JM Kim, K Kaptan, K Nilsson, KM Riggs, L Clement, L Pezawas, M Folstein, M Hamilton, MH Kamphuis, NP Rao, Peter van Loon, PG Dagnelie, RJ Loffeld, RJ Loffeld, SA Lipton, TB Robins Wahlin, Y Gumurdulu, Yener Güzelcan   +35 more
core   +6 more sources

Multisectoral Convergence of Food, Nutrition and Sanitation Programs for Child Health: Evidence From Country‐Level Programs in India

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT This paper underscores the critical role of multisectoral convergence in enhancing child health, particularly in addressing anemia, a micronutrient deficiency linked to both diet and sanitation. We explore how the integration of nationwide food and nutrition programs with sanitation initiatives impacts anemia in Indian children under three ...
Soumya Gupta, Payal Seth, Prabhu Pingali
wiley   +1 more source