Vitamin K epoxide reductase: homology, active site and catalytic mechanism
Trends in Biochemical Sciences, 2004 Vitamin K epoxide reductase (VKOR) recycles reduced vitamin K, which is used subsequently as a co-factor in the gamma-carboxylation of glutamic acid residues in blood coagulation enzymes. VKORC1, a subunit of the VKOR complex, has recently been shown to possess this activity.
Goodstadt, L, Ponting, C
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New insights on vitamin K metabolism in senegalese sole (Solea senegalensis) based on ontogenetic and tissue-specific vitamin K epoxide reductase molecular data [PDF]
, 2020 Vitamin K (VK) is a key nutrient for several biological processes (e.g., blood clotting and bone metabolism). To fulfill VK nutritional requirements, VK action as an activator of pregnane X receptor (Pxr) signaling pathway, and as a co-factor of γ ...
Silvia Beato +11 more
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Investigation of the Function and Evolution of Vitamin K Epoxide Reductases [PDF]
Vitamin K epoxide reductase complex subunit 1 (VKORC1) is an important enzyme in the vitamin K cycle, and the target of anticoagulant rodenticides. Polymorphisms identified in VKORC1 in Rattus norvegicus (brown rat) can cause anticoagulant resistance. Previous studies have shown several anticoagulant resistance polymorphisms that are found in the UK in
Hollis, Zoe
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Pharmacokinetics and efficacy of oral versus intravenous mixed-micellar phylloquinone (vitamin K-1) in severe acute liver disease [PDF]
, 2005 Background/Aims: In patients with severe acute liver dysfunction, i.v. phylloquinone (vitamin K-1) may be given to exclude vitamin K deficiency, rather than impaired hepatic synthesis of coagulation factors alone, as the cause of the coagulopathy ...
Pereira, SP +13 more
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Overexpression of protein disulfide isomerase enhances vitamin K epoxide reductase activity [PDF]
, 2022 International audienceVitamin K epoxide reductase (VKOR) activity is catalyzed by the VKORC1 enzyme. It is a target of vitamin K antagonists (VKA). Numerous mutations of VKORC1 have been reported and are suspected to confer resistance to VKA and (or ...
Lattard, Virginie +4 more
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Mycobacterium tuberculosis Vitamin K Epoxide Reductase Homologue Supports Vitamin K–Dependent Carboxylation in Mammalian Cells [PDF]
, 2012 Aims: Vitamin K epoxide reductase complex, subunit 1 (VKORC1) is a critical participant in the production of active forms of reduced vitamin K and is required for modification of vitamin K–dependent proteins. Homologues of VKORC1 (VKORH) exist throughout
Jin, Da-Yun +2 more
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Vitamin K-dependent carboxylase Possible role for thioredoxin in the reduction of vitamin K metabolites in liver [PDF]
, 1987 In the liver vitamin K epoxide, which is produced during the posttranslational carboxylation of proteinbound glutamic acid residues, is recycled by the action of one or more dithiol-dependent reductases.
Vermeer, Cees +5 more
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Vitamin K and childhood cancer: a report from the United Kingdom Childhood Cancer Study [PDF]
, 2003 The relationship between neonatal vitamin K received by the intramuscular (i.m.) route and the development of leukaemia or other cancers was investigated as part of a national case–control study of childhood cancer, using data abstracted from obstetric ...
Eden, O.B. +24 more
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Vitamin K epoxide reductase: moving closer to nature [PDF]
Blood, 2018 In this issue of Blood, Chen et al have used a novel cell-based assay to evaluate the antagonist effects of 4 clinically prescribed vitamin K antagonists (VKAs) on the activity of vitamin K epoxide reductase (VKOR) and its VKA-resistant mutants in their natural cellular environment ...
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Indirect inhibition of vitamin K epoxide reduction by salicylate
, 1984 Salicylate antagonizes the vitamin K-dependent biosynthesis of clotting factors in the rat and produces an elevation of the ratio of vitamin K epoxide to vitamin K in the liver.
E Hildebrandt, J W Suttie
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