Results 31 to 40 of about 8,906,109 (167)

Atmospheric Aerosol Neurotoxicity and Parkinson's Disease: Mechanisms and Perspectives

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Schematic overview of the pathways and pathological mechanisms connecting atmospheric aerosol exposure to PD. Atmospheric aerosols, including PM2.5 and nanometer/ultrafine particles loaded with metal particles, persistent organic pollutants (POPs), polycyclic aromatic hydrocarbons (PAHs) and dioxins, enter the body predominantly via pulmonary ...
Yitian Gao, Minxiang Dong, Chenyang Duan, Xiaohan Zheng, Liming Qu   +4 more
wiley   +1 more source

Vitamin K Epoxide Reductase Complex and Vascular Calcification [PDF]

Circulation, 2006
Vitamin K is a cofactor in the γ-glutamyl carboxylation pathway, a posttranslational conversion of specific glutamate residues into γ-carboxyglutamic acid (Gla) residues, catalyzed by the endoplasmic reticulum enzyme γ-glutamyl carboxylase. The substrates of carboxylase are the so-called vitamin K–dependent proteins, which are involved in diverse ...
openaire   +2 more sources

The effects of salicylate on enzymes of vitamin K metabolism

, 1983
The mechanism of salicylate-induced hypoprothrombinaemia has been investigated in the rat. Salicylate administration produced an increase in the percentage of the total liver vitamin that was present as vitamin K 2,3-epoxide, but the addition of ...
J W Suttie, E F Hildebrandt
core   +1 more source

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

Vitamin K epoxide reductase regulation of androgen receptor activity

Oncotarget, 2017
Long-term use of warfarin has been shown to be associated with a reduced risk of prostate cancer. Warfarin belongs to the vitamin K antagonist class of anticoagulants, which inhibit vitamin K epoxide reductase (VKOR). The vitamin K cycle is primarily known for its role in γ-carboxylation, a rare post-translational modification important in blood ...
Tew, Ben Yi, Hong, Teresa B., Otto-Duessel, Maya, Elix, Catherine, Castro, Egbert, He, Miaoling, Wu, Xiwei, Pal, Sumanta K., Kalkum, Markus, Jones, Jeremy O.   +9 more
openaire   +3 more sources

The association between dietary vitamin K intake and serum undercarboxylated osteocalcin is modulated by vitamin K epoxide reductase genotype [PDF]

, 2008
Vitamin K acts as a cofactor during the gamma-carboxylation of vitamin K-dependent proteins. Undercarboxylated osteocalcin (ucOC) is a suggested biomarker of vitamin K status.
Nimptsch, Katharina, Nieters, A., Linseisen, J., Nieters, Alexandra, Linseisen, Jakob, Wolfram, Günther, Hailer, Susanne, Hailer, S., Nimptsch, K., Wolfram, G.   +9 more
core   +1 more source

The History of the Discovery of Vitamin K

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 3, September 2026.
ABSTRACT Vitamin K was discovered during the 1930s when a strange haemorrhagic disorder was observed in chickens fed a cholesterol‐free diet. A fat‐soluble agent, present in green leafy vegetables and hog liver, was able to restore haemostasis in the chickens.
Hanna Nørgaard Tuxen, Laila Zwisler, Allan Linneberg   +2 more
wiley   +1 more source

Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation [PDF]

, 2011
Background Cytochrome-P450 (CYP450) epoxygenases metabolise arachidonic acid (AA) into four different biologically active epoxyeicosatrienoic acid (EET) regioisomers.
Geisslinger, Gerd, Gerd Geisslinger, Brandes, Ralf P., Brandes, Ralf, Michael J Fischer, Fleming, Ingrid, Scholich, Klaus, Woolf Clifford J, Ralf P Brandes, Clifford J Woolf, Fleming Ingrid, Reeh, Peter Werner, Brenneis Christian, Fischer, Michael, Coste Ovidiu, Coste, Ovidiu, Brandes Ralf P, Kai Altenrath, Reeh Peter W, Christian Brenneis, Scholich Klaus, Sisignano, Marco, Reeh, Peter W., Altenrath Kai, Ingrid Fleming, Peter W Reeh, Woolf, Clifford J., Angioni Carlo, Geisslinger Gerd, Angioni, Carlo Federico, Klaus Scholich, Brenneis, Christian, Ovidiu Coste, Carlo Angioni, Sisignano Marco, Marco Sisignano, Fischer, Michael J., Fischer Michael J, Altenrath, Kai, Angioni, Carlo   +39 more
core   +3 more sources

Cloning and application of epoxide hydrolases from yeasts [PDF]

, 2002
Epoxides are cyclic ethers that readily react with various nucleophilic compounds. Consequently, epoxides can be used in many chemical synthesis reactions. Two enantiomeric forms of an epoxide are possible if one of the carbon atoms is chiral. This means
Visser, J.H.
core  

Distribution and frequency of Vkorc1 polymorphisms in house mice and Norway rats in the northeastern United States

Pest Management Science, Volume 82, Issue 8, Page 7700-7710, August 2026.
This study assesses the distribution and frequency of Vkorc1 polymorphisms in house mice and Norway rats in northeastern USA. House mice showed higher frequency of Vkorc1 mutations than Norway rats. The A32V and Y139F mutations are first reported in mice, and the L128V is newly reported in Norway rats.
Jin‐Jia Yu, Alvaro Toledo, Adrienne E Kasprowicz, Megan V Phifer‐Rixey, Xiaodan Pan, Babatunji Daramola, Changlu Wang   +6 more
wiley   +1 more source