Results 41 to 50 of about 8,906,109 (167)

Studies on the relationship between microsomal epoxide hydrolase and the vitamin K epoxide reductase complex.

, 2000
Studies on the relationship between microsomal epoxide hydrolase and the vitamin K epoxide reductase ...
Danlin. Cai (7951235)
core   +1 more source

Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease [PDF]

, 2010
Epoxyeicotrienoic acids (EETs) are cytochrome P450-dependent anti-hypertensive and anti-inflammatory derivatives of arachidonic acid, which are highly abundant in the kidney and considered reno-protective.
Geisslinger, Gerd, Gerd Geisslinger, Tsai, Cindy, Ralf P. Brandes, Brandes, Ralf, Schäfer, Liliana, Amann Kerstin, Liliana Schaefer, Kerstin Amann, Felix Jansen, Jung, Oliver, Ralf P Brandes, Mieth Anja, Hwang Sung H., Schaefer Liliana, Anja Mieth, Hwang, Sung H., Barbosa-Sicard Eduardo, Sung H. Hwang, Bruce D. Hammock, Hammock Bruce D., Christophe Morisseau, Cindy Tsai, Rainer U. Pliquett, Oliver Jung, Brandes Ralf P., Pliquett Rainer U., Mieth, Anja, Babelova, Andrea, Barbosa Sicard, Eduardo, Geisslinger Gerd, Jansen, Felix, Andrea Babelova, Sung H Hwang, Morisseau, Christophe, Pliquett, Rainer U., Eduardo Barbosa-Sicard, Jung Oliver, Rainer U Pliquett, Bruce D Hammock, Jansen Felix, Tsai Cindy, Morisseau Christophe, Amann, Kerstin, Hammock, Bruce D., Babelova Andrea   +45 more
core   +2 more sources

eNOS Uncoupling, Shear‐Stress Tolerance, and the Two‐Threshold Model of Post‐Exertional Malaise in Long COVID: A Mechanistic Hypothesis With Implications for Physiotherapy and Recovery Protocols

Microcirculation, Volume 33, Issue 6, August 2026.
ABSTRACT Objective To propose and make testable a mechanistic hypothesis for post‐exertional malaise (PEM) in a clinically distinct subset of Long COVID patients, in whom delayed exertional symptoms coexist with consistently normal macrovascular investigations.
Yiannis K. Karipidis, Konstantinos Y. Karipidis   +1 more
wiley   +1 more source

Warfarin and vitamin K epoxide reductase: a molecular accounting for observed inhibition [PDF]

Blood, 2018
Key PointsWarfarin reversibly inhibits VKOR by forming a T-shaped stacking interaction with residue Y139 of the proposed TYA warfarin-binding motif. Warfarin-resistant nonbleeding phenotype for patients bearing VKOR mutations explained by MD simulation and cell-based functional study.
Sangwook Wu, Xuejie Chen, Da-Yun Jin, Darrel W. Stafford, Lee G. Pedersen, Jian-Ke Tie   +5 more
openaire   +2 more sources

Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods

Chirality, Volume 38, Issue 7, July 2026.
Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz, Cigdem Karaaslan Kirmizioglu   +1 more
wiley   +1 more source

Vitamin D with calcium reduces mortality: patient level pooled analysis of 70,528 patients from eight major vitamin D trials. [PDF]

, 2012
Introduction: Vitamin D may affect multiple health outcomes. If so, an effect on mortality is to be expected. Using pooled data from randomized controlled trials, we performed individual patient data (IPD) and trial level meta-analyses to assess ...
Salovaara, K., Smith, H.E., Jackson, Rebecca D, Sanders, Kerrie M., Jacobs, ET, Rebecca D Jackson (16135031), Sanders, KM, Tahir Masud (804313), Jacobs, E.T., JoAnn E Manson (13567339), Robbins, John A., Salovaara, K, Haakon E Meyer (10282121), Rejnmark, Lars, Abrahamsen, Bo, Jackson, Rebecca D., Mosekilde, Leif, Brixen, K., Mosekilde, L., Robbins, JA, Cyrus Cooper (141250), Lars Rejnmark (3752971), Mosekilde, L, Elizabeth T Jacobs (16135028), Bo Abrahamsen (650396), Meyer, Haakon E., Jackson, RD, Alison Avenell (82040), Jacobs, Elizabeth T., Smith, Helen E, Abrahamsen, Bo; id_orcid, Brixen, K, Salovaara, Kari, Manson, Joann E, Torgerson, D., Robbins, J.A., Avenell, A, Robbins, John A, Francis, Roger M., Roger M Francis (7380278), Abrahamsen, B, Masud, T, Jacobs, Elizabeth T, Manson, JoAnn E., Anderson, F., Francis, R.M., Kerrie M Sanders (13488952), Francis, RM, David Torgerson (462403), Masud, T., Helen E Smith (16045475), Abrahamsen, B., Manson, J.E., Cooper, Cyrus, Sanders, K.M., Frazer Anderson (16135022), Meyer, Haakon E, Anderson, F, Torgerson, D, Kari Salovaara (16135025), Meyer, H.E., Rejnmark, L, Francis, Roger M, John A Robbins (8553495), Torgerson, David, Masud, Tahir, Smith, HE, Anderson, Frazer, Cooper, C., Meyer, HE, Kim Brixen (16135034), Jackson, R.D., Smith, Helen E., Cooper, C, Rejnmark, L., Manson, JE, Avenell, Alison, Avenell, A., Brixen, Kim, Leif Mosekilde (349340), Sanders, Kerrie M   +80 more
core   +1 more source

Remodelling the tumour microenvironment and beyond: ERO1A as a multifaceted regulator and emerging therapeutic target in cancer

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
ERO1A exhibits oncogenic functions, including promoting tumour progression, metastasis, epithelial‒mesenchymal transition, angiogenesis, immune evasion and metabolic reprogramming. ERO1A is also identified as a diagnostic biomarker and a factor contributing to therapy resistance (chemotherapy and immunotherapy).
Jing Mao, Kai Wang
wiley   +1 more source

The Influence of (R)- and (S)-Warfarin, Vitamin K and Vitamin K Epoxide upon Warfarin Anticoagulation

, 2000
SummaryThe contribution of (R)and (S)-warfarin enantiomers, vitamin K and vitamin K epoxide and patient factors to inter-individual variability in daily warfarin requirements were examined in a group of 73 patients.
Clive Edwards, Farhad Kamali, Hilary Wynne, Timothy Butler   +3 more
core   +1 more source

Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

Phytotherapy Research, Volume 40, Issue 7, Page 4676-4709, July 2026.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández, Sara Elis Bianchi, Flávia Nathiely Silveira Fachel, Elizandra Braganhol, Sheila Porto de Matos, Valquíria Linck Bassani   +5 more
wiley   +1 more source

Pyridylmethyl Radicals for Enantioselective Alkene Hydroalkylation Using “Ene”-Reductases

, 2023
Aromatic electron-deficient heterocycles, such as pyridines, are found in many biologically relevant structures, including those with medicinal applications.
Sophie G. Bender (17310718), Todd K. Hyster (1323081)   +1 more
core   +1 more source