Results 21 to 30 of about 8,906,109 (167)

Microsomal lipoamide reductase provides vitamin K epoxide reductase with reducing equivalents [PDF]

Biochemical Journal, 1994
This study was undertaken to search for the endogenous dithiol cofactor of the reductases of the vitamin K cycle. As a starting point, the redox-active lipophilic endogenous compounds lipoic acid and lipoamide were looked at. The study shows that microsomes contain NADH-dependent lipoamide reductase activity.
H H, Thijssen, Y P, Janssen, L T, Vervoort   +2 more
openaire   +2 more sources

Beyond deficiency:Potential benefits of increased intakesof vitamin K for bone and vascular health [PDF]

, 2004
Vitamin K is wellknown for its role in the synthesisof a number of blood coagulationfactors.During recent years vitaminK-dependent proteins werediscovered to be of vital importancefor bone and vascular health.Recommendations for dietary vitaminK intake ...
Vermeer, C, Weber, P, Zittermann, A, Shearer, M, Szulc, P, Walter, P, Stocklin, E, Bolton-Smith, C, Rambeck, W, Hodges, S   +9 more
core  

Dispensing of actionable pharmacogenetic drugs among adults receiving cardiovascular disease medications in the Northern Netherlands: A serial cross‐sectional study

Clinical Pharmacology &Therapeutics, EarlyView.
The extent of pharmacogenetic (PGx) drug dispensing among Dutch adults receiving medications for cardiovascular disease (CVD) is unknown. Using the University of Groningen IADB.nl pharmacy database, we performed a serial cross‐sectional study (2019–2023) to estimate the annual prevalence of PGx drug dispensing and annual rates of initiation.
Zhuolin Zhang, Guiling Zhou, Jens H. J. Bos, Eelko Hak, Talitha Feenstra, Frank Klont   +5 more
wiley   +1 more source

The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

Epilepsia Open, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar, Majd A. AbuAlrob, Musab Ali, Simona Lattanzi, Boulenouar Mesraoua   +4 more
wiley   +1 more source

A hetero-dimer model for concerted action of vitamin K carboxylase and vitamin K reductase in vitamin K cycle [PDF]

, 2011
Vitamin K carboxylase (VKC) is believed to convert vitamin K, in the vitamin K cycle, to an alkoxide-epoxide form which then reacts with CO2 and glutamate to generate γ-carboxyglutamic acid (Gla).
Charles H. Davis, Lee G. Pedersen, Kulman, John D., Pedersen, Lee G., Sangwook Wu, Wu, Sangwook, Darrel W. Stafford, Stafford, Darrel W., Liu, Shubin, Shubin Liu, John D. Kulman, Davis, Charles H.   +11 more
core   +1 more source

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

Phytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko, Victoriya Georgiyants, Liudas Ivanauskas, Olha Mykhailenko   +3 more
wiley   +1 more source

Congenital deficiency of vitamin K dependent coagulation factors in two families presents as a genetic defect of the vitamin K-epoxide-reductase-complex

, 2000
Hereditary combined deficiency of the vitamin K dependent coagulation factors is a rare bleeding disorder. To date, only eleven families have been reported in the literature.
Wolz, W., von Brederlow, B., Fregin, A., Eberl, W., Schwabb, R., Brackmann, H. H., Rost, S., Harbrecht, U., Oldenburg, Johannes, Lenz, E., Mueller, C. R., Eber, S., Effenberger, W., Schurgers, L. J., Vermeer, C.   +14 more
core   +2 more sources

Is thioredoxin the physiological vitamin K epoxide reducing agent? [PDF]

, 1992
E. coli thioredoxin plus thioredoxin reductase have previously been shown to replace dithiothreitol as the electron donor for mammalian liver microsomal vitamin K epoxide reduction in vitro.
Peter C. Preusch, Preusch, Peter C.
core   +1 more source

Do We Really Know How to Manage Anticoagulated Patients for Periodontal Nonsurgical Therapy? An Observational Cohort Study

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Objectives The aim of this work is to assess and compare the impact of direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKA) during and immediately after periodontal nonsurgical therapy. Materials and Methods A prospective observational cohort study was conducted with patients who presented a history of cardiovascular disease ...
F. Berton, A. Rapani, F. Costantinides, V. Nicolin, D. Cuhureanu, R. Di Lenarda   +5 more
wiley   +1 more source

Membrane Topology Mapping of Vitamin K Epoxide Reductase by in Vitro Translation/Cotranslocation [PDF]

, 2005
Membrane topology mapping of vitamin K epoxide reductase by in vitro translation ...
Tie, Jian Ke, Von Heijne, Gunnar, Stafford, Darrel W., Nicchitta, Christopher   +3 more
core   +1 more source