Results 71 to 80 of about 7,461 (205)

Missense mutation of VKORC1 leads to medial arterial calcification in rats

Scientific Reports, 2018
Vitamin K plays a crucial role in the regulation of vascular calcifications by allowing activation of matrix Gla protein. The dietary requirement for vitamin K is low because of an efficient recycling of vitamin K by vitamin K epoxide reductase (VKORC1).
Arnaud Michaux, Benjamin Matagrin, Jean-Valéry Debaux, Leon J. Schurgers, Etienne Benoit, Virginie Lattard   +5 more
doaj   +1 more source

Frequencies of polymorphisms in genes affecting the pharmacokinetics of warfarin in the Zaporizhzhia region

Zaporožskij Medicinskij Žurnal, 2021
The aim of the study: to establish the frequencies of polymorphisms in VKORC1, CYP2C9 and CYP4F2 genes among residents of the Zaporizhzhia region. Materials and methods. A total of 150 persons (62 male, 88 female) with a median age of 46 years (26; 58)
M. Yu. Kolesnik, Yа. М. Mykhailovskyi
doaj   +1 more source

Vitamin K‐induced modification of coagulation phenotype in VKORC1 homozygous deficiency [PDF]

Journal of Thrombosis and Haemostasis, 2008
Combined vitamin K-dependent clotting factor (VKCF) deficiency type 2 (VKCFD2) is a rare bleeding disorder caused by mutated vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) gene.An Italian patient with moderate to severe bleeding tendency was genotyped, and found to be homozygous for the unique VKORC1 mutation (Arg98Trp) so far detected in ...
MARCHETTI, Giovanna, CARUSO, Pierpaolo, LUNGHI, Barbara, PINOTTI, Mirko, M. Lapecorella, M. Napolitano, CANELLA, Alessandro, G. Mariani, BERNARDI, Francesco   +8 more
openaire   +3 more sources

Efavirenz and CYP2C9 Genetic Polymorphisms Reduce CYP2C9 Activity in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Efavirenz's effects on cytochrome P450 2C9 (CYP2C9) activity have not been formally characterized in vivo. We conducted the first clinical drug–drug interaction (DDI) study to test the effect of chronic efavirenz dosing on CYP2C9 activity, using tolbutamide as a selective probe.
Jason D. Kim, Ingrid F. Metzger, Jessica Bo Li Lu, Todd C. Skaar, Zeruesenay Desta   +4 more
wiley   +1 more source

Патогенетичне значення поліморфізму генів циклу вітаміну К для розвитку ішемічного атеротромботичного інсульту [PDF]

, 2017
Дисертація присвячена вивченню впливу поліморфних варіантів генів циклу вітаміну К (G-1639A і С1173Т гена VKORC1 та Arg406Arg гена GGCX) на розвиток ішемічного атеротромботичного інсульту (ІАТІ).
Dubovyk, Yevhen Ivanovych, Дубовик, Евгений Иванович, Дубовик, Євген Іванович   +2 more
core   +1 more source

Insights Into Patient‐Level Exposure to Actionable Pharmacogenomic Medications in Australia Using a New National Pharmacogenomic Guideline

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 89-100, January 2026.
This study assessed the use of 35 pharmacogenomic (PGx) medications listed in the Royal College of Pathologists of Australasia (RCPA) guideline, estimated the potential costs of subsidizing PGx testing in Australia, and predicted related prescribing changes.
Bella D. Ianni, Chin Hang Yiu, Mohammad A. Ali, Christine Y. Lu   +3 more
wiley   +1 more source

Polymorphisms of genes CYP2C9 and VKORC1 in patients with venous thromboembolic complications in Moscow population: effects on stability of anticoagulant therapy and frequency of hemorrhage

Терапевтический архив, 2011
Aim. To investigate frequency of carriage of genetic polymorphisms CYP2C9 and VKORC1 in patients with venous thromboembolic complications (VTEC) in Moscow population given warfarin treatment and effects of this carriage on stability of anticoagulation ...
Natal'ya Mikhaylovna Vorob'eva, Elizaveta Pavlovna Panchenko, Anatoliy Borisovich Dobrovol'skiy, Elena Vladimirovna Titaeva, Zukhra Bilyalovna Khasaeva, Nina Valer'evna Konovalova, Anton Yuvenal'evich Postnov, Aleksandr Ivanovich Kirienko, N M Vorobyeva, E P Panchenko, A B Dobrovolsky, E V Titaeva, Z B Khasaeva, N V Konovalova, A Yu Postnov, A I Kirienko   +15 more
doaj  

Pharmacogenetics of warfarin: A literature review [PDF]

КардиоСоматика
Warfarin is an oral indirect anticoagulant that is widely used for the prevention of thromboembolic events. Pharmacogenetic testing is the most promising approach to personalizing warfarin treatment. In this review, we aimed to summarize how the patients’
Nadezhda V. Izmozherova, Muraz A. Shambatov, Artem A. Popov, Daria E. Zhuk, Viktoria A. Solodchenko   +4 more
doaj   +1 more source

CYP2C9 VE VKORC1 GENLERİNİN PROSTAT KANSERİ ETYOLOJİSİNDEKİ ROLLERİNİN ARAŞTIRILMASI

Sağlık Bilimleri Dergisi, 2019
1. Amaç: Çalışmamızda, Sitokrom p450 enzimlerini kodlayan CYP ve vitamin K epoksit redüktaz kompleks subünit1 enzimini kodlayan VKORC1 genlerinin alt gruplarındaki tek nükleotit polimorfizmlerinin muhtemel bireysel ve ortak etkilerini prostat kanseri hastalarında araştırmayı amaçladık.
Ali Osman ARSLAN, Selma DÜZENLİ
openaire   +4 more sources

Clinical Implementation of Pharmacogenomics and Drug–Drug Interaction Screening in a German Academic Teaching Hospital and Outpatient Follow‐Up

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 241-254, January 2026.
Overview of the implemented pharmacogenomics (PGx) process in clinical routine at the Robert Bosch Hospital: from patient enrollment via the hospital information system, DNA detection using a customized TaqMan OpenArray panel and qPCR for CNV assessment, to clinical translation of genotyping results into PGx guideline‐based recommendations using a ...
Roman Tremmel, Filippa Schreeck, Simon Jaeger, Severin Schricker, Elke Schaeffeler, Svitlana Igel, Daniela Steinberger, Manuel Pagitz, Jörg Latus, Markus Ketteler, Kerstin Bühl, Marc‐H. Dahlke, Hans‐Georg Kopp, Matthias Schwab   +13 more
wiley   +1 more source