Results 11 to 20 of about 71,736 (190)

AtALMT12 represents an R-type anion channel required for stomatal movement in Arabidopsis guard cells [PDF]

Plant Journal, 2010
Stomatal pores formed by a pair of guard cells in the leaf epidermis control gas exchange and transpirational water loss. Stomatal closure is mediated by the release of potassium and anions from guard cells. Anion efflux from guard cells involves slow (S-
Al-Rasheid, K A S, Endler, A, Geiger, D, Hedrich, R, Imes, D, Marten, I, Martinoia, E, Meyer, S, Mumm, P, Weder, B   +9 more
core   +3 more sources

Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis [PDF]

Nature Communications, 2021
The authors found that VDAC2 plays a crucial role in influencing mitochondrial calcium dynamics and cellular calcium signalling. A VDAC2 agonist, efsevin, rescued the heart failure phenotype, identifying a new potential therapeutic target for heart ...
Thirupura S. Shankar, Dinesh K. A. Ramadurai, Kira Steinhorst, Salah Sommakia, Rachit Badolia, Aspasia Thodou Krokidi, Dallen Calder, Sutip Navankasattusas, Paulina Sander, Oh Sung Kwon, Aishwarya Aravamudhan, Jing Ling, Andreas Dendorfer, Changmin Xie, Ohyun Kwon, Emily H. Y. Cheng, Kevin J. Whitehead, Thomas Gudermann, Russel S. Richardson, Frank B. Sachse, Johann Schredelseker, Kenneth W. Spitzer, Dipayan Chaudhuri, Stavros G. Drakos   +23 more
doaj   +2 more sources

MicroED structure of lipid-embedded mammalian mitochondrial voltage-dependent anion channel. [PDF]

Proc Natl Acad Sci U S A, 2020
Significance Microcrystal electron diffraction (MicroED) is an electron cryo-microscopy (cryoEM) method for determining structures using submicron crystals. Until now, determining structures of membrane proteins by MicroED required that the protein crystals be in a solution amenable to standard cryoEM blotting and vitrification ...
Martynowycz MW, Khan F, Hattne J, Abramson J, Gonen T.   +4 more
europepmc   +7 more sources

Identification and validation of voltage‐dependent anion channel 1‐related genes and immune cell infiltration in diabetic nephropathy [PDF]

Journal of Diabetes Investigation
Aims/Introduction This study investigated the roles of voltage‐dependent anion channel 1‐related differentially expressed genes (VRDEGs) in diabetic nephropathy (DN).
Jiaqun Lin, Mengjie Weng, Jing Zheng, Kun Nie, Siyi Rao, Yongjie Zhuo, Jianxin Wan   +6 more
doaj   +2 more sources

Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels. [PDF]

PLoS ONE, 2008
Type II hexokinase is overexpressed in most neoplastic cells, and it mainly localizes on the outer mitochondrial membrane. Hexokinase II dissociation from mitochondria triggers apoptosis.
Federica Chiara, Diego Castellaro, Oriano Marin, Valeria Petronilli, William S Brusilow, Magdalena Juhaszova, Steven J Sollott, Michael Forte, Paolo Bernardi, Andrea Rasola   +9 more
doaj   +1 more source

VDAC1 (voltage-dependent anion channel 1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on VDAC1 (voltage-dependent anion channel 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Shoshan-Barmatz, V, Mizrachi, D
openaire   +2 more sources

Conductance hysteresis in the voltage-dependent anion channel [PDF]

European Biophysics Journal, 2015
Hysteresis in the conductance of voltage-sensitive ion channels is observed when the transmembrane voltage is periodically varied with time. Although this phenomenon has been used in studies of gating of the voltage-dependent anion channel, VDAC, from the outer mitochondrial membrane for nearly four decades, full hysteresis curves have never been ...
Rappaport, Shay M., Teijido Hermida, Óscar, Hoogerheide, David P., Rostovtseva, Tatiana K., Berezhkovskii, Alexander M., Bezrukov, Sergey M.   +5 more
openaire   +3 more sources

Voltage-dependent anion channels mediated apoptosis in refractory epilepsy [PDF]

Open Medicine, 2020
Abstract The purpose of this study was to investigate the role of voltage-dependent anion channel (VDAC) in mitochondria-mediated apoptosis of neurons in refractory epilepsy. Western blot analyses were carried out to detect the changes in cytochrome C, caspase 9, Bax, and Bcl-2.
Zhao Yan, Jiang Wen-Jing, Ma Lin, Lin Yan, Wang Xing-Bang   +4 more
openaire   +3 more sources

Functional dynamics in the voltage-dependent anion channel [PDF]

Proceedings of the National Academy of Sciences, 2010
The voltage-dependent anion channel (VDAC), located in the outer mitochondrial membrane, acts as a gatekeeper for the entry and exit of mitochondrial metabolites. Here we reveal functional dynamics of isoform one of VDAC (VDAC1) by a combination of solution NMR spectroscopy, Gaussian network model analysis, and molecular dynamics simulation.
Villinger, S., Briones, R., Giller, K., Zachariae, Ulrich, Lange, A., De Groot, B.L., Griesinger, C., Becker, S., Zweckstetter, M.   +8 more
openaire   +5 more sources

Structure of the human voltage-dependent anion channel [PDF]

Proceedings of the National Academy of Sciences, 2008
The voltage-dependent anion channel (VDAC), also known as mitochondrial porin, is the most abundant protein in the mitochondrial outer membrane (MOM). VDAC is the channel known to guide the metabolic flux across the MOM and plays a key role in mitochondrially induced apoptosis.
Bayrhuber, M., Meins, T., Habeck, M., Becker , S., Giller, K., Villinger , S., Vonrhein, C., Griesinger, C., Zweckstetter, M., Zeth, K.   +9 more
openaire   +7 more sources