Results 251 to 260 of about 33,802 (280)
Modulation of the mitochondrial voltage dependent anion channel (VDAC) by curcumin
Biochimica Et Biophysica Acta - Biomembranes, 2015 Voltage dependent anion channel (VDAC) of mitochondria plays a crucial role in apoptosis. Human VDAC-1, reconstituted in planar lipid bilayer showed reduced conductance when treated with curcumin. Curcumin interacts with residues in the α helical N-terminus of VDAC and in the channel wall, as revealed by molecular docking, followed by mutational ...
Debanjan Tewari +2 more
exaly +4 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Structure of the voltage dependent anion channel: state of the art
Journal of Bioenergetics and Biomembranes, 2008The eukaryotic porin or Voltage Dependent Anion-selective Channels (VDAC) is the protein forming the aqueous pore channel in the mitochondrial outer membrane. It can modulate the energy-dependent metabolism of the cell forming a diffusion barrier to ions, adenine-nucleotides and other metabolites and it is probably involved in the regulation of ...
DE PINTO, Vito Nicola +3 more
openaire +2 more sources
The Supramolecular Assemblies of Voltage-dependent Anion Channels in the Native Membrane
Journal of Molecular Biology, 2007Voltage-dependent anion channels (VDACs) are major constituents of the outer mitochondrial membrane (OMM). These primary transporters of nucleotides, ions and metabolites mediate a substantial portion of the OMM molecular traffic. To study the native supramolecular organization of the VDAC, we have isolated, characterized and imaged OMMs from potato ...
Hoogenboom, B. W. +3 more
openaire +4 more sources
Voltage‐dependent anion channels: Key players in viral infection
Reviews in Medical Virology, 2023AbstractViruses control the host cell by exploiting its molecular machinery to facilitate viral replication and propagation. Understanding different viral mechanisms and biochemical pathways is crucial for finding promising therapeutic solutions to viral infections. The mitochondrion is a vital organelle targeted by various types of viruses.
Ahmed H. Saadawy +4 more
openaire +2 more sources
Acta Crystallographica Section F: Structural Biology Communications, 2008 The major channel by which metabolites can pass through the outer mitochondrial membrane is formed by the voltage-dependent anion-channel (VDAC) family.
Kornelius Zeth
exaly +2 more sources
Voltage-dependent anion channels: the wizard of the mitochondrial outer membrane
Biological Chemistry, 2014Abstract Voltage dependent anion channels (VDACs) are the most abundant proteins in the outer mitochondrial membrane. Although they are essential in metabolite exchange, cell defense and apoptosis, the molecular mechanism of these VDAC-mediated processes remains elusive. Here we review recent progress in terms of VDACs’ structure and regulation, with a
Barbara, Mertins +2 more
openaire +2 more sources
Modulation of the voltage-dependent anion channel of mitochondria by elaidic acid
Biochemical and Biophysical Research Communications, 2016Dietary trans fatty acids (TFAs) are known to increase the risk of cardiovascular diseases by altering plasma lipid profile and activating various inflammatory signaling pathways. Here we show that elaidic acid (EA), the most abundant TFA in diet, alters the electrophysiological properties of voltage-dependent anion channel (VDAC) of mitochondria ...
Debanjan Tewari, Amal Kanti Bera
openaire +2 more sources
Voltage-dependent anion channels are a key factor of male fertility
Fertility and Sterility, 2013To examine how voltage-dependent anion channels (VDACs) regulate sperm function in capacitation conditions.Experimental prospective study.Academic research laboratory.Male ICR and female B6D2F1/CrljOri mice (8-12 weeks old).Female mice were superovulated with 5 IU of pregnant mare serum gonadotropin given IP and 5 IU of hCG given IP 48 hours later ...
Woo-Sung, Kwon +3 more
openaire +2 more sources
The voltage-dependent anion channel as a biological transistor: theoretical considerations
European Biophysics Journal, 2003The voltage-dependent anion channel (VDAC) is a porin of the mitochondrial outer membrane with a bell-shaped permeability-voltage characteristic. This porin restricts the flow of negatively charged metabolites at certain non-zero voltages, and thus might regulate their flux across the mitochondrial outer membrane. Here, we have developed a mathematical
V V, Lemeshko, S V, Lemeshko
openaire +2 more sources
Journal of Bioenergetics and Biomembranes, 1989
The methods for the purification of functionally active mitochondrial porin or voltage-dependent anion channel of the outer mitochondrial membrane are critically evaluated. Two rapid and efficient methods are now available. Both make use of a hydroxyapatite/celite column as a single chromatographic step.
PALMIERI F, DE PINTO, Vito Nicola
openaire +2 more sources
The methods for the purification of functionally active mitochondrial porin or voltage-dependent anion channel of the outer mitochondrial membrane are critically evaluated. Two rapid and efficient methods are now available. Both make use of a hydroxyapatite/celite column as a single chromatographic step.
PALMIERI F, DE PINTO, Vito Nicola
openaire +2 more sources