Results 51 to 60 of about 71,736 (190)

The voltage-dependent anion channel-1 modulates apoptotic cell death [PDF]

Cell Death & Differentiation, 2005
The role of the voltage-dependent anion channel (VDAC) in cell death was investigated using the expression of native and mutated murine VDAC1 in U-937 cells and VDAC inhibitors. Glutamate 72 in VDAC1, shown previously to bind dicyclohexylcarbodiimide (DCCD), which inhibits hexokinase isoform I (HK-I) binding to mitochondria, was mutated to glutamine ...
H, Zaid, S, Abu-Hamad, A, Israelson, I, Nathan, V, Shoshan-Barmatz   +4 more
openaire   +2 more sources

Cepharanthine induces ROS stress in glioma and neuronal cells via modulation of VDAC permeability

Saudi Pharmaceutical Journal, 2020
Cepharanthine (CEP) is a bisbenzylisoquinoline alkaloid. Molecular dynamics studies show that CEP interacts with Voltage-dependent anion channel (VDAC), inducing the voltage-independent channel narrowing.
Karolina Cierluk, Wojciech Szlasa, Joanna Rossowska, Mounir Tarek, Anna Szewczyk, Jolanta Saczko, Julita Kulbacka   +6 more
doaj   +1 more source

Voltage-Dependent Anion Channel 1 As an Emerging Drug Target for Novel Anti-Cancer Therapeutics

Frontiers in Oncology, 2017
Cancer cells share several properties, high proliferation potential, reprogramed metabolism, and resistance to apoptotic cues. Acquiring these hallmarks involves changes in key oncogenes and non-oncogenes essential for cancer cell survival and prosperity,
Varda Shoshan-Barmatz, Yakov Krelin, Anna Shteinfer-Kuzmine, Tasleem Arif   +3 more
doaj   +1 more source

secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila [PDF]

, 2019
Organisms use circulating diuretic hormones to control water balance (osmolarity), thereby avoiding dehydration and managing excretion of waste products.
Dent, J., Drapeau, P., Feingold, D., Knogler, L., Nilson, L., O'Donnell, M., Starc, T.   +6 more
core   +2 more sources

Voltage‐dependent anion‐selective channel (VDAC) in the plasma membrane

FEBS Letters, 2010
Voltage‐dependent anion channels (VDACs) have originally been characterized as mitochondrial porins. Starting in the late 1980s, however, evidence began to accumulate that VDACs can also be expressed in plasma membranes. In this review, we briefly revisit the historical milestones in the discovery of plasma membrane‐bound VDAC, and we critically ...
DE PINTO, Vito Nicola, MESSINA, Angela Anna, D. J. LANE, A. LAWEN   +3 more
openaire   +2 more sources

Lidocaine promotes apoptosis in breast cancer cells by affecting VDAC1 expression

BMC Anesthesiology, 2022
Objective To investigate the effect of lidocaine on the expression of voltage-dependent anion channel 1 (VDAC1) in breast invasive carcinoma (BRCA) and its impact on the apoptosis of breast cancer cells.
Dingde Long, Xingjun Fang, Peihua Yuan, Liqin Cheng, Hongtao Li, LiangChao Qu   +5 more
doaj   +1 more source

TSPO: kaleidoscopic 18-kDa amid biochemical pharmacology, control and targeting of mitochondria [PDF]

, 2016
The 18-kDa translocator protein (TSPO) localizes in the outer mitochondrial membrane (OMM) of cells and is readily up-regulated under various pathological conditions such as cancer, inflammation, mechanical lesions and neurological diseases. Able to bind
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core   +1 more source

Voltage Dependent Anion Channel Is Redistributed during Japanese Encephalitis Virus Infection of Insect Cells

The Scientific World Journal, 2014
Despite the availability of an effective vaccine, Japanese encephalitis remains a significant cause of morbidity and mortality in many parts of Asia.
Chanida Fongsaran, Narumon Phaonakrop, Sittiruk Roytrakul, Chutima Thepparit, Atichat Kuadkitkan, Duncan R. Smith   +5 more
doaj   +1 more source

Two-electrode Voltage-clamp Recordings in Xenopus laevis Oocytes：Reconstitution of Abscisic Acid Activation of SLAC1 Anion Channel via PYL9 ABA Receptor

Bio-Protocol, 2017
Two-Electrode Voltage-Clamp (TEVC) recording in Xenopus laevis oocytes provides a powerful method to investigate the functions and regulation of ion channel proteins.
cun wang, Jingbo Zhang, Julian Schroeder
doaj   +1 more source

Electrogenic transport and K(+) ion channel expression by the human endolymphatic sac epithelium. [PDF]

, 2015
The endolymphatic sac (ES) is a cystic organ that is a part of the inner ear and is connected to the cochlea and vestibule. The ES is thought to be involved in inner ear ion homeostasis and fluid volume regulation for the maintenance of hearing and ...
Choi, Jae Young, Jung, JinSei, Kim, Bo Gyung, Kim, Jin Young, Kim, Sung Huhn, Moon, In Seok, Moon, Sung K, Roh, Kyung Jin, Suh, Michelle J   +8 more
core   +2 more sources