Cell demise inhibited: Unexpected liaisons between mitochondria and IκΒα
Molecular & Cellular Oncology, 2021 IκΒα (the protein product of NFKBIA gene) has widely been considered a pro- apoptotic factor due to its ability to inhibit the anti-apoptotic transcription factor NFκB.
Evangelos Pazarentzos
doaj +1 more source
Hydrogen sulphide regulates inward-rectifying K+ channels in conjunction with stomatal closure [PDF]
, 2015 Hydrogen sulphide (H2S) is the third biological gasotransmitter and, in animals, affects many physiological processes by modulating ion channels. H2S has been reported to protect plants from oxidative stress in diverse physiological responses. H2S closes
Blatt, Mike R. +3 more
core +2 more sources
Age-dependent posttranslational modifications of voltage-dependent anion channel 1
Experimental Gerontology, 2010 The accumulation of oxidative damage in mitochondrial proteins, membranes and DNA during ageing is supposed to lead to mitochondrial inactivation, downstream molecular impairments and subsequent decline of biological systems. In a quantitative study investigating the age-related changes of mitochondrial proteins on the level of oxidative ...
Karlfried, Groebe +8 more
openaire +2 more sources
Advanced Science, 2023 Cadmium (Cd) is a high‐risk pathogenic toxin for hepatic diseases. Excessive mitophagy is a hallmark in Cd‐induced hepatotoxicity. However, the underlying mechanism remains obscure.
Cong Liu +9 more
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Silencing VDAC1 Expression by siRNA Inhibits Cancer Cell Proliferation and Tumor Growth In Vivo
Molecular Therapy: Nucleic Acids, 2014 Alterations in cellular metabolism and bioenergetics are vital for cancer cell growth and motility. Here, the role of the mitochondrial protein voltage-dependent anion channel (VDAC1), a master gatekeeper regulating the flux of metabolites and ions ...
Tasleem Arif +4 more
doaj +1 more source
Neuronal Protection by Ha-RAS-GTPase Signaling through Selective Downregulation of Plasmalemmal Voltage-Dependent Anion Channel-1. [PDF]
Int J Mol SciThe small GTPase RAS acts as a plasma membrane-anchored intracellular neurotrophin counteracting neuronal degeneration in the brain, but the underlying molecular mechanisms are largely unknown. In transgenic mice expressing constitutively activated V12-Ha-RAS selectively in neurons, proteome analysis uncovered a 70% decrease in voltage-dependent anion ...
Neumann S +2 more
europepmc +4 more sources
Single-channel measurements of an N-acetylneuraminic acid-inducible outer membrane channel in Escherichia coli [PDF]
, 2012 NanC is an Escherichia coli outer membrane protein involved in sialic acid (Neu5Ac, i.e., N-acetylneuraminic acid) uptake. Expression of the NanC gene is induced and controlled by Neu5Ac. The transport mechanism of Neu5Ac is not known.
Eisenberg, Bob +4 more
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Bio-Protocol, 2017 Two-Electrode Voltage-Clamp (TEVC) recording in Xenopus laevis oocytes provides a powerful method to investigate the functions and regulation of ion channel proteins.
cun wang, Jingbo Zhang, Julian Schroeder
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Self-organised criticality and 1/ f noise in single-channel current of voltage-dependent anion channel [PDF]
Europhysics Letters (EPL), 2006 Noise profile of Voltage Dependent Anion Channel (VDAC) is investigated in open channel state. Single-channel currents through VDAC from mitochondria of rat brain reconstituted into a planar lipid bilayer are recorded under different voltage clamped conditions across the membrane.
Banerjee, Jyotirmoy +3 more
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Characterization of constitutive and acid-induced outwardly rectifying chloride currents in immortalized mouse distal tubular cells [PDF]
, 2017 Thiazides block Na+ reabsorption while enhancing Ca2 + reabsorption in the kidney. As previously demonstrated in immortalized mouse DCT (MDCT) cells, chlorothiazide application induced a robust plasma membrane hyperpolarization, which increased Ca2 ...
Shrier, Alvin +2 more
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