Results 71 to 80 of about 9,496 (202)

Strategies for maximizing ATP supply in the microsporidian Encephalitozoon cuniculi: direct binding of mitochondria to the parasitophorous vacuole and clustering of the mitochondrial porin VDAC [PDF]

, 2013
Microsporidia are obligate intracellular parasites with extremely reduced genomes and a dependence on host-derived ATP. The microsporidium Encephalitozoon cuniculi proliferates within a membranous vacuole and we investigated how the ATP supply is ...
Howell, Matthew, Hacker, Christian, Lucocq, John Milton, Lucocq, John, Bhella, David   +4 more
core   +1 more source

Demonstration of beat‐to‐beat, on‐demand ATP synthesis in ventricular myocytes reveals sex‐specific mitochondrial and cytosolic dynamics

The Journal of Physiology, EarlyView.
Abstract figure legend Beat‐locked mitochondrial ATP transients reveal modular, sex‐specific bioenergetic control during excitation–contraction coupling. A, each action potential activates L‐type CaV1.2 channels, producing a Ca2+ influx that triggers ryanodine receptors (RyR2) and elicits SR Ca2+ release.
Paula Rhana, Collin Matsumoto, L. Fernando Santana   +2 more
wiley   +1 more source

Voltage‐dependent anion channel (VDAC‐1) is required for olfactory sensing in Caenorhabditis elegans [PDF]

Genes to Cells, 2015
The Ras–MAP kinase signaling pathway plays important roles for the olfactory reception in olfactory neurons in Caenorhabditis elegans. However, given the absence of phosphorylation targets of MAPK in the olfactory neurons, the mechanism by which this pathway regulates olfactory function is unknown.
Takayuki, Uozumi, Masayuki, Hamakawa, Yu-Ki, Deno, Nobushige, Nakajo, Takaaki, Hirotsu   +4 more
openaire   +2 more sources

Structure of the human voltage-dependent anion channel.

, 2008
The voltage-dependent anion channel (VDAC), also known as mitochondrial porin, is the most abundant protein in the mitochondrial outer membrane (MOM).
Vonrhein, C., Giller, K., Habeck, M. ; https://orcid.org/, Zeth, K., Villinger, S., Bayrhuber, M., Becker , S., Becker, Stefan, Zweckstetter, Markus, Villinger , S., Giller, Karin, Zweckstetter, M., Villinger, Saskia, Becker, S., Bayrhuber, Monika, Habeck, Michael, Meins, Thomas, Griesinger, C., Vonrhein, Clemens, Zeth, Kornelius, Meins, T., Griesinger, Christian, Habeck, M.   +22 more
core   +2 more sources

拟南芥AtGluRS相互作用蛋白质VDAC及其转基因植物表型分析

四川大学学报. 自然科学版, 2010
电压依赖性阴离子通道蛋白质(voltage-dependent anion channel,VDAC)是拟南芥谷氨酰tRNA合成酶(AtGluRS)相互作用的蛋白质.为了研究VDAC蛋白的功能和作用,通过构建VDAC稳定表达载体,农杆菌介导的方法转化拟南芥,筛选和鉴定出VDAC过量和抑制表达植株.研究结果证实VDAC的过量和抑制表达植株影响气孔关闭和种子萌发.VDAC的过量表达导致植株对ABA敏感,VDAC的抑制表达降低了植株对ABA的敏感性.推测VDAC蛋白可能参与ABA信号途径.
何菡, 严金平, 张建军, 刘震, 张皖蓉, 童仕波, 杨毅   +6 more
doaj  

Insights into VDAC Gating: Room-Temperature X-ray Crystal Structure of mVDAC-1

Biomolecules
The voltage-dependent anion channel (VDAC) is a crucial mitochondrial protein that facilitates ion and metabolite exchange between mitochondria and the cytosol. Initially characterized over three decades ago, the structure of VDAC-1 was resolved in 2008,
Kristofer R. Gonzalez-DeWhitt, Natalia Ermolova, Harrison K. Wang, Doeke R. Hekstra, Thorsten Althoff, Jeff Abramson   +5 more
doaj   +1 more source

The voltage-dependent anion selective channel 1 (VDAC1) topography in the mitochondrial outer membrane as detected in intact cell.

PLoS ONE, 2013
Voltage-Dependent Anion selective Channel maintains the permeability of the outer mitochondrial membrane and is relevant in bioenergetic metabolism and apoptosis. The structure of the protein was shown to be a β-barrel formed by 19 strands.
Marianna F Tomasello, Francesca Guarino, Simona Reina, Angela Messina, Vito De Pinto   +4 more
doaj   +1 more source

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel

, 2010
Nitric oxide (NO) effects on the cardiac mitochondrial voltage-dependent anion channel (VDAC) are unknown. The effects of exogenous NO on VDAC purified from rat hearts were investigated in this study.
Cheng, Qunli, Kwok, Wai-Meng, Danijel Pravdic, Zeljko J. Bosnjak, Sedlic, Filip, Pravdic, Danijel, Wai-Meng Kwok, Filip Sedlic, Bosnjak, Zeljko J., Qunli Cheng   +9 more
core   +1 more source

Molecular Plasticity of the Human Voltage-Dependent Anion Channel Embedded Into a Membrane [PDF]

, 2016
The voltage-dependent anion channel (VDAC) regulates the flux of metabolites and ions across the outer mitochondrial membrane. Regulation of ion flow involves conformational transitions in VDAC, but the nature of these changes has not been resolved to ...
Stefania A. Mari, Mari, S., Müller, Daniel J., Giller, K., Stefan Becker, Lin Ge, Mari, Stefania A., Karin Giller, Villinger, S., Ge, Lin, Becker, Stefan, Zweckstetter, Markus, Müller, D., Giller, Karin, Zweckstetter, M., Markus Zweckstetter, Villinger, Saskia, Becker, S., Daniel J. Müller, Christian Griesinger, Griesinger, C. ; https://orcid.org/, Saskia Villinger, Griesinger, Christian, Ge, L.   +23 more
core   +1 more source