Results 71 to 80 of about 9,039 (171)

Cysteine Oxidations in Mitochondrial Membrane Proteins: The Case of VDAC Isoforms in Mammals

Frontiers in Cell and Developmental Biology, 2020
Cysteine residues are reactive amino acids that can undergo several modifications driven by redox reagents. Mitochondria are the source of an abundant production of radical species, and it is surprising that such a large availability of highly reactive ...
Simona Reina, Maria Gaetana Giovanna Pittalà, Francesca Guarino, Angela Messina, Vito De Pinto, Salvatore Foti, Rosaria Saletti   +6 more
doaj   +1 more source

Organelle Crosstalk and Metabolic Reprogramming in Idiopathic Pulmonary Fibrosis: Mechanisms and Therapeutic Implications

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease of unknown cause, marked by excessive deposition of extracellular matrix (ECM) components such as collagen. This pathological accumulation results in progressive destruction of the lung architecture and ultimately leads to respiratory failure.
Yining Zhang, Ling Teng, Limin Gong, Yuandong Fu, Minyi Qian   +4 more
wiley   +1 more source

Drosophila Porin/VDAC affects mitochondrial morphology.

PLoS ONE, 2010
Voltage-dependent anion channel (VDAC) has been suggested to be a mediator of mitochondrial-dependent cell death induced by Ca(2+) overload, oxidative stress and Bax-Bid activation.
Jeehye Park, Yongsung Kim, Sekyu Choi, Hyongjong Koh, Sang-Hee Lee, Jin-Man Kim, Jongkyeong Chung   +6 more
doaj   +1 more source

Chronic Contractile Activity Remediates Lysosomal Dysfunction in a Muscle Cell Lysosomal Disease Model

Journal of Cellular Physiology, Volume 241, Issue 9, September 2026.
Bafilomycin A1‐induced lysosomal dysfunction can be mitigated by CCA in muscle myotubes. The curcumin analogue C1 similarly decreases lysosomal accumulation, modestly improves function and increases mitochondrial content, suggesting that both CCA and C1 may represent potential strategies for alleviating lysosomal dysfunction and supporting muscle cell ...
Debasmita Bhattacharya, Neushaw Moradi, David A. Hood   +2 more
wiley   +1 more source

Mitochondria as the Hub of Apoptosis: A Comprehensive Insight From Mitochondria to Interactions With Other Organelles

MedComm, Volume 7, Issue 9, September 2026.
Mitochondria is the hub of apoptosis in various diseases. The disruption of mitochondrial structure (including membrane rupture, cristae remodeling, and mitochondrial membrane lipid redistribution), the imbalance of mitochondrial dynamics (including fusion and fission, autophagy), the release, disruption, and mutation of mitochondria DNA, as well as ...
Rubin Tan, Jinming Zhao, Rong Wang, Yue Shi, Zaozao Chen, Yixuan Ma, Na Li, Wenqing Duan, Duo Lin, Chunxiang Zhang   +9 more
wiley   +1 more source

Structural basis of apoptosis induction by the mitochondrial voltage-dependent anion channel

Nature Communications
The voltage-dependent anion channel (VDAC) is the main gateway for metabolites across the mitochondrial outer membrane. VDAC oligomers are connected to apoptosis induced by various stimuli.
Melina Daniilidis, Umut Günsel, Georgios Broutzakis, Kira D. Leitl, Robert Janowski, Kai Fredriksson, Dierk Niessing, Christos Gatsogiannis, Franz Hagn   +8 more
doaj   +1 more source

Upregulation of Glucose Uptake and Hexokinase Activity of Primary Human CD4+ T Cells in Response to Infection with HIV-1

Viruses, 2018
Infection of primary CD4+ T cells with HIV-1 coincides with an increase in glycolysis. We investigated the expression of glucose transporters (GLUT) and glycolytic enzymes in human CD4+ T cells in response to infection with HIV-1.
Maia Kavanagh Williamson, Naomi Coombes, Florian Juszczak, Marios Athanasopoulos, Mariam B. Khan, Thomas R. Eykyn, Ushani Srenathan, Leonie S. Taams, Julianna Dias Zeidler, Andrea T. Da Poian, Hendrik Huthoff   +10 more
doaj   +1 more source

Genome-wide identification, characterization and expression pattern analysis of the VDAC gene family reveals likely roles in rapid shoot growth and abiotic stress in Moso bamboo ((Phyllostachys edulis (Carrière) J.Houz.)

Advances in Bamboo Science
Moso bamboo is an important fast-growing forest species. The rapid growth of its shoots and its ability to respond to environmental stresses, such as drought and low temperatures, directly influence its shoot yield and quality.
Zhen Yu, Sijia Cai, Xueyun Xuan, Shiying Su, Jiaqi Tan, Zhijun Zhang   +5 more
doaj   +1 more source

Voltage-Dependent Anion Channels in Male Reproductive Cells: Players in Healthy Fertility?

Biomolecules
Male infertility affects nearly 50% of infertile couples, with various underlying causes, including endocrine disorders, testicular defects, and environmental factors. Spermatozoa rely on mitochondrial oxidative metabolism for motility and fertilization,
Stefano Conti Nibali, Giuseppe Battiato, Xena Giada Pappalardo, Vito De Pinto   +3 more
doaj   +1 more source

The small yeast GTPase Rho5 requires specific mitochondrial outer membrane proteins for translocation under oxidative stress and interacts with the VDAC Por1

European Journal of Cell Biology
Yeast Rho5 is a small GTPase which mediates the response to nutrient and oxidative stress, and triggers mitophagy and apoptosis. We here studied the rapid translocation of a GFP-tagged Rho5 to mitochondria under such stress conditions by live-cell ...
Linnet Bischof, Franziska Schweitzer, Hans-Peter Schmitz, Jürgen J. Heinisch   +3 more
doaj   +1 more source