Results 91 to 100 of about 9,496 (202)

Fluoxetine (Prozac) interaction with the mitochondrial voltage-dependent anion channel and protection against apoptotic cell death

, 2005
Fluoxetine (Prozac) is a potent antidepressant compound inhibiting serotonin reuptake, but also Na+, K+ and Ca2+ channels and reported to both trigger and prevent apoptosis.
Nahon, Edna, Abu-Hamad, Salah, Shoshan-Barmatz, Varda, Adrian Israelson, Salah Abu-Hamad, Varda Shoshan-Barmatz, Israelson, Adrian, Edna Nahon   +7 more
core   +1 more source

The single residue K12 governs highly sensitive voltage gating of the voltage-dependent anion channel

, 2023
International audienceThe voltage-dependent anion channel (VDAC) has emerged as a key player in mitochondrial bioenergetics. As the main pathway for calcium and mitochondrial metabolites, such as ATP and ADP, to cross the mitochondrial outer membrane ...
Hoogerheide, David, Noskov, Sergei, Bezrukov, Sergey, Khan, Farha, Ngo, Van, Rostovtseva, Tatiana, Bergdoll, Lucie, Abramson, Jeff, Queralt-Martin, Maria   +8 more
core   +1 more source

Pro‐ and Anti‐Inflammatory Macrophages Adjust UCP2 Protein Levels Based on Their Intrinsic Metabolism and Available Metabolites

European Journal of Immunology, Volume 56, Issue 6, June 2026.
LPS‐stimulated macrophages exhibit high glycolytic flux, with pyruvate preferentially converted to lactate even under normoglycemic conditions, limiting pyruvate availability for the tricarboxylic acid (TCA) cycle and reducing oxygen consumption rate (OCR).
Jila Nasirzade, Felix Sternberg, Andrea Vogel, Roko Sango, Taraneh Beikbaghban, Thomas Kolbe, Thomas Rattei, Thomas Weichhart, Elena E. Pohl   +8 more
wiley   +1 more source

Structural and functional analysis of a salt stress inducible gene encoding voltage dependent anion channel (VDAC) from pearl millet (Pennisetum glaucum)

, 2006
We have cloned and characterized a gene encoding voltage-dependent anion channel from Pennisetum glaucum (PgVDAC). PgVDAC was identified while isolating genes that were differentially up-regulated following salt stress. The genomic organization of PgVDAC
Reddy, M. K., Verma, D., Nair, S., Desai, M. K., Sopory, S. K., Mishra, R. N.   +5 more
core   +1 more source

Upregulation of Glucose Uptake and Hexokinase Activity of Primary Human CD4+ T Cells in Response to Infection with HIV-1

Viruses, 2018
Infection of primary CD4+ T cells with HIV-1 coincides with an increase in glycolysis. We investigated the expression of glucose transporters (GLUT) and glycolytic enzymes in human CD4+ T cells in response to infection with HIV-1.
Maia Kavanagh Williamson, Naomi Coombes, Florian Juszczak, Marios Athanasopoulos, Mariam B. Khan, Thomas R. Eykyn, Ushani Srenathan, Leonie S. Taams, Julianna Dias Zeidler, Andrea T. Da Poian, Hendrik Huthoff   +10 more
doaj   +1 more source

Proteomic analysis of cellular models of neurodegeneration and mitochondrial dysfunction

, 2009
Mitochondrial dysfunction is thought to contribute to neurodegenerative processes. As an example, dysfunction of complex I of the electron transport chain has been observed in Parkinson’s disease patients and 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (
Burté, F, Burte, Florence
core  

Crystallization and preliminary X-ray crystallographic studies of human voltage-dependent anion channel isoform I (HVDAC1)

, 2008
The major channel by which metabolites can pass through the outer mitochondrial membrane is formed by the voltage-dependent anion-channel (VDAC) family.
Vonrhein, C., Zeth, K. ; https://orcid.org/, Meins, T.   +2 more
core   +1 more source

β-Barrel mobility underlies closure of the voltage-dependent anion channel

, 2012
The voltage-dependent anion channel (VDAC) is the major protein in the outer mitochondrial membrane, where it mediates transport of ATP and ADP. Changes in its permeability, induced by voltage or apoptosis-related proteins, have been implicated in ...
Benz, Roland, Zachariae, U., Zweckstetter, Markus, Gattin, Z., Zachariae, Ulrich; id_orcid, Maier, E., Becker, S., Zachariae, Ulrich, Demers, Jean-Philippe, Briones, R., De Groot, Bert L., Benz, R., Griesinger, Christian, Giller, K., Groot, Bert L. de, Schneider, R., de Groot, B., Lange, A., Gattin, Zrinka, Becker, Stefan, Giller, Karin, Maier, Elke, Zweckstetter, M., Schneider, Robert, Griesinger, C., Griesinger, C. ; https://orcid.org/, Demers, J., Lange, Adam, Briones, Rodolfo, Demers, Jean-Phillipe   +29 more
core   +2 more sources

Genome-wide identification, characterization and expression pattern analysis of the VDAC gene family reveals likely roles in rapid shoot growth and abiotic stress in Moso bamboo ((Phyllostachys edulis (Carrière) J.Houz.)

Advances in Bamboo Science
Moso bamboo is an important fast-growing forest species. The rapid growth of its shoots and its ability to respond to environmental stresses, such as drought and low temperatures, directly influence its shoot yield and quality.
Zhen Yu, Sijia Cai, Xueyun Xuan, Shiying Su, Jiaqi Tan, Zhijun Zhang   +5 more
doaj   +1 more source

Channel characteristics of VDAC-3 from Arabidopsis thaliana.

, 2015
International audienceFour different isoforms of the Voltage-Dependent Anion Channel (VDAC) have been identified in Arabidopsis plant cells. The electrophysiological characteristics of several VDAC channels from animal as well as plant cells are well ...
Peyronnet, Rémi, Ephritikhine, Genevieve, Betton, Jean-Michel, Ghazi, Alexandre, Frachisse, Jean-Marie, Barbier-Brygoo, Hélène, Berrier, Catherine   +6 more
core   +1 more source