Results 101 to 110 of about 13,998 (216)

Calcium signaling as a mediator of cell energy demand and a trigger to cell death [PDF]

, 2015
Calcium signaling is pivotal to a host of physiological pathways. A rise in calcium concentration almost invariably signals an increased cellular energy demand.
Alavian, Baines, Baines, Baughman, Berridge, Beutner, Bonora, Brenner, Báthori, Carafoli, Chouchani, Crompton, Crompton, Csordas, Davidson, Denton, Duchen, Dumollard, Erecinska, Favero, Fliss, Fryer, Fujimoto, Giorgio, Giricz, Goodman, Griffiths, Grill, Gutiérrez-Aguilar, Haase, Hajnoczky, Halestrap, Halestrap, Hausenloy, Hausenloy, Haworth, Haworth, Haynes, He, Hoffman, Hoffman, Hunter, Hunter, Ichas, Imahashi, King, Kokoszka, Korge, Kwong, Kwong, Lasorsa, Lehninger, Lemasters, Llorente-Folch, Logan, Luongo, Mallilankaraman, Mallilankaraman, Mouri, Murphy, Nosek, Palma, Pan, Pardo, Paupe, Perocchi, Przyklenk, Quan, Raffaello, Rao, Rapizzi, Rizzuto, Rohacs, Ruck, Schinzel, Seidlmayer, Sileikyte, Stefani, Stys, Tranum-Jensen, Varanyuwatana, Vinogradov, Werth, Yang   +83 more
core   +1 more source

FAM162A Is a Key Regulator of Mitochondrial Structure, Dynamics, and Bioenergetics, Driving Cellular Protection and Longevity

Aging Cell, Volume 25, Issue 5, May 2026.
FAM162A, localized within mitochondrial cristae, emerges as a novel regulator of mitochondrial dynamics. It post‐translationally modulates OPA1, maintaining cristae structure and boosting cellular bioenergetics. This key interaction enhances cell viability, stress resistance, and overall organismal health.
Andrea Matamoros, Juan Pablo Soffia, Marcelo Muñoz, Michael Maturana, Ma Andreina Rangel‐Ramirez, Alvaro Gonzalez‐Ibañez, Gabriela Gómez‐Lillo, Cesar Astorga, Lina M. Ruiz, Ramón A. Jorquera, Alejandra San Martín, Alvaro A. Elorza   +11 more
wiley   +1 more source

Evaluation of Porin Interaction with Adenine Nucleotide Translocase and Cyclophilin-D Proteins after Brain Ischemia and Reperfusion [PDF]

, 2011
Objective (s) Porin is a mitochondrial outer membrane channel, which usually functions as the pathway for the movement of various substances in and out of the mitochondria and is considered to be a component of the permeability transition (PT) pore ...
Jose Luis Perez Velazquez, Mohammad Ali Atlasi   +1 more
core  

Preoperative Beta‐Hydroxy‐Beta‐Methyl‐Butyrate Supplementation Reduces Mitochondrial Dynamics Proteins and Preserves Hepatic Mitochondrial Function After Partial Hepatectomy in Mice

Acta Physiologica, Volume 242, Issue 5, May 2026.
ABSTRACT Aim The liver exhibits a remarkable regenerative capacity, enabling this organ to maintain homeostasis even after significant injury. However, hepatic regeneration requires sufficient energy to sustain cellular hypertrophy and proliferation, thus ensuring efficient tissue repair.
A. L. Vieira‐da‐Silva, M. V. Esteca, F. A. Silva, I. A. Divino, F. S. Carneiro, E. R. Ropelle, A. S. Torsoni, I. L. Baptista   +7 more
wiley   +1 more source

Emerging Role of Ferroptosis in Diabetes and Associated Complications: When Metabolic Dysregulation Meets Cell Death

Cell Proliferation, Volume 59, Issue 5, May 2026.
This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang, Ying Zhang, Yue Xu, Mengyuan Yang, Yuan Wei, Yuan Li, Tongyue Yang, Xu Wang, Chaona Yang, Qi Feng, Guolan Xing   +10 more
wiley   +1 more source

Cell‐Type‐Dependent Metabolic Compensation Preserves Photoreceptor Survival Through Pyruvate Kinase Isoform Balance

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
We investigated the roles of PKM2, PKM1, and LDHA in retinal metabolism and structural integrity. In the normal retina, these enzymes are maintained at defined levels that support photoreceptor function. Rod‐specific deletion of LDHA, alone or with PKM2, caused age‐dependent degeneration, as PKM1 induction did not reach levels comparable to PKM2.
Ammaji Rajala, Larissa J. Trevino, Tyler M. Black, Raju V. S. Rajala   +3 more
wiley   +1 more source

Upregulation of Glucose Uptake and Hexokinase Activity of Primary Human CD4+ T Cells in Response to Infection with HIV-1

Viruses, 2018
Infection of primary CD4+ T cells with HIV-1 coincides with an increase in glycolysis. We investigated the expression of glucose transporters (GLUT) and glycolytic enzymes in human CD4+ T cells in response to infection with HIV-1.
Maia Kavanagh Williamson, Naomi Coombes, Florian Juszczak, Marios Athanasopoulos, Mariam B. Khan, Thomas R. Eykyn, Ushani Srenathan, Leonie S. Taams, Julianna Dias Zeidler, Andrea T. Da Poian, Hendrik Huthoff   +10 more
doaj   +1 more source

External and internal triggers of cell death in yeast [PDF]

, 2016
In recent years, yeast was confirmed as a useful eukaryotic model system to decipher the complex mechanisms and networks occurring in higher eukaryotes, particularly in mammalian cells, in physiological as well in pathological conditions.
FALCONE, Claudio, MAZZONI, Cristina
core   +2 more sources

Targeting mitochondrial 18 kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype [PDF]

, 2014
The aim of the present study was to establish mitochondrial cholesterol trafficking 18 kDa translocator protein (TSPO) as a potential therapeutic target, capable of increasing macrophage cholesterol efflux to (apo)lipoprotein acceptors.
Anne-Marie Allen, Annette Graham, Batarseh, Bird, Borthwick, Borthwick, Brown, Dmitrova-Shumkovska, Engel, Falchi, Farke, Feramisco, Fernandez-Hernando, Gallus, Gerrity, Gut, Hebbachi, Janice M. W. Taylor, Kannel, Khan, Lecanu, Madamanchi, Mercer, Ning, Ning, Ogata, Oram, Pandak, Puddu, Pyper, Rae, Ren, Rigamonti, Rone, Rosenson-Schloss, Rupprecht, Schnoor, Schultz, Taylor, Vanhee, Venkateswaran, Wang, Xu, Yelieev, Zeng, Zeng, Zoltan   +46 more
core   +1 more source

Genome-wide identification, characterization and expression pattern analysis of the VDAC gene family reveals likely roles in rapid shoot growth and abiotic stress in Moso bamboo ((Phyllostachys edulis (Carrière) J.Houz.)

Advances in Bamboo Science
Moso bamboo is an important fast-growing forest species. The rapid growth of its shoots and its ability to respond to environmental stresses, such as drought and low temperatures, directly influence its shoot yield and quality.
Zhen Yu, Sijia Cai, Xueyun Xuan, Shiying Su, Jiaqi Tan, Zhijun Zhang   +5 more
doaj   +1 more source