Results 81 to 90 of about 13,998 (216)

The mitochondrial‐targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial‐apoptotic but not necroptotic signalling during ovarian cancer

The Journal of Physiology, EarlyView.
Abstract figure legend An evaluation of the degree to which mitochondrial hydrogen peroxide emission (mH2O2)‐mediated apoptotic and necroptotic signalling contributes to skeletal muscle atrophy in an orthotopic epithelial ovarian cancer (EOC) model. To determine whether attenuating mH2O2 could prevent regulated cell death signalling and mitigate muscle
Shahrzad Khajehzadehshoushtar, Luca J. Delfinis, Fasih A. Rahman, Madison C. Garibotti, Shivam Gandhi, Aditya N. Brahmbhatt, Brooke A. Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie Ogilvie, Zhu‐Xu Zhang, Jeremy A. Simpson, Joe Quadrilatero, Jim Petrik, Christopher G. R. Perry   +15 more
wiley   +1 more source

Mitochondrial calcium signaling and neurodegenerative diseases [PDF]

, 2018
Calcium is utilised by cells in signalling and in regulating ATP production; it also contributes to cell survival and, when concentrations are unbalanced, triggers pathways for cell death.
Britti, Elena, Delaspre, Fabien, Ros Salvador, Joaquim, Tamarit Sumalla, Jordi   +3 more
core   +3 more sources

Ro5‐4864, a ligand of the mitochondrial translocator protein, protects against heart failure in mice via regulation of the p62‐Keap1‐Nrf2 axis

The Journal of Physiology, EarlyView.
Abstract figure legend Graphical abstract of the proposed Ro5‐4864 mechanism of action via p62‐Keap1‐Nrf2 axis in heart failure. TSPO, the 18‐kDa mitochondrial translocator protein of the outer mitochondrial membrane, can directly interact with p62 (also known as SQSTM1), which is crucial for the degradation of damaged mitochondria by autophagy ...
Daphne A. Diloretto, Phung N. Thai, Gabriela Grigorean, Veneese J. Brown, Tjien Dwyer, Nipavan Chiamvimonvat, Elena N. Dedkova, Saul Schaefer   +7 more
wiley   +1 more source

Enhanced expression of the voltage-dependent anion channel 1 (VDAC1) in Alzheimer's disease transgenic mice: an insight into the pathogenic effects of amyloid-β [PDF]

, 2011
The mitochondrial voltage-dependent anion channel 1 (VDAC1) is involved in the release of apoptotic proteins with possible relevance in Alzheimer's disease (AD) neuropathology.
Cabodevilla, F. (Felipe), Cuadrado-Tejedor, M. (Mar), Frechilla, D. (Diana), Perez-Mediavilla, L.A. (Luis Alberto), Rio, J. (Joaquín) del, Vilariño, M. (Marcos)   +5 more
core  

Voltage-dependent structural changes of the membrane-bound anion channel hVDAC1 probed by SEIRA and electrochemical impedance spectroscopy [PDF]

, 2014
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence
Becker, Stefan, Giller, Karin, Hildebrandt, Peter, Kozuch, Jacek, Millo, Diego, Steinem, Claudia, Weichbrodt, Conrad   +6 more
core   +1 more source

Demonstration of beat‐to‐beat, on‐demand ATP synthesis in ventricular myocytes reveals sex‐specific mitochondrial and cytosolic dynamics

The Journal of Physiology, EarlyView.
Abstract figure legend Beat‐locked mitochondrial ATP transients reveal modular, sex‐specific bioenergetic control during excitation–contraction coupling. A, each action potential activates L‐type CaV1.2 channels, producing a Ca2+ influx that triggers ryanodine receptors (RyR2) and elicits SR Ca2+ release.
Paula Rhana, Collin Matsumoto, L. Fernando Santana   +2 more
wiley   +1 more source

Insights into VDAC Gating: Room-Temperature X-ray Crystal Structure of mVDAC-1

Biomolecules
The voltage-dependent anion channel (VDAC) is a crucial mitochondrial protein that facilitates ion and metabolite exchange between mitochondria and the cytosol. Initially characterized over three decades ago, the structure of VDAC-1 was resolved in 2008,
Kristofer R. Gonzalez-DeWhitt, Natalia Ermolova, Harrison K. Wang, Doeke R. Hekstra, Thorsten Althoff, Jeff Abramson   +5 more
doaj   +1 more source

The voltage-dependent anion selective channel 1 (VDAC1) topography in the mitochondrial outer membrane as detected in intact cell.

PLoS ONE, 2013
Voltage-Dependent Anion selective Channel maintains the permeability of the outer mitochondrial membrane and is relevant in bioenergetic metabolism and apoptosis. The structure of the protein was shown to be a β-barrel formed by 19 strands.
Marianna F Tomasello, Francesca Guarino, Simona Reina, Angela Messina, Vito De Pinto   +4 more
doaj   +1 more source

Voltage‐dependent anion channel (VDAC‐1) is required for olfactory sensing in Caenorhabditis elegans [PDF]

Genes to Cells, 2015
The Ras–MAP kinase signaling pathway plays important roles for the olfactory reception in olfactory neurons in Caenorhabditis elegans. However, given the absence of phosphorylation targets of MAPK in the olfactory neurons, the mechanism by which this pathway regulates olfactory function is unknown.
Takayuki, Uozumi, Masayuki, Hamakawa, Yu-Ki, Deno, Nobushige, Nakajo, Takaaki, Hirotsu   +4 more
openaire   +2 more sources

Mitochondrial DNA: A Key Alarmin Igniting the Inflammasome Fire in Health and Disease

Immunology, Volume 178, Issue 2, Page 218-230, June 2026.
This review illustrates how mitochondrial DNA, released under cellular stress, acts as a key alarmin that ignites innate immune sensors, particularly inflammasomes and the cGAS‐STING pathway. This paper details how this sustained “inflammasome fire” fuels the progression of diverse inflammatory diseases, including neurodegeneration and metabolic ...
Woo Hyun Park
wiley   +1 more source