Results 81 to 90 of about 9,496 (202)

Signalosomes in the brain. Relevance in the development of certain neuropathologies such as Alzheimer’s Disease

Frontiers in Physiology, 2011
Emerging data suggest that compartmentalization of signaling molecules into particular membrane compartments, or lipid rafts, may be at the basis of numerous activities related to neuronal preservation against different pathologies.
Raquel eMarin
doaj   +1 more source

Advances in the Core Role and Mechanisms of Mitochondrial Dysfunction in Alzheimer's Disease

Brain and Behavior, Volume 16, Issue 7, July 2026.
In Alzheimer's disease, Aβ and Tau trigger mitochondrial dysfunction, driving a pathological cascade that results in cognitive decline. Gut microbiota dysbiosis exacerbates this via the gut–brain axis, making mitochondria a key therapeutic target. ABSTRACT Introduction Alzheimer's disease (AD) is a complex neurodegenerative disorder whose pathogenesis ...
Tianyi Gu, Hangyan Guo, Zixin Guo, Shengyu Hua   +3 more
wiley   +1 more source

Opening of plasma membrane voltage-dependent anion channels (VDAC) precedes caspase activation in neuronal apoptosis induced by toxic stimuli

, 2005
Apoptotic cell death is an essential process in the development of the central nervous system and in the pathogenesis of its degenerative diseases. Efflux of K+ and Cl- ions leads to the shrinkage of the apoptotic cell and facilitates the activation of ...
Tofighi, R.,, Akanda, Nesar,, Shimizu, S.,, R Tofighi, Y Tsujimoto, Elinder, Fredrik,, S Orrenius, S Shimizu, Tsujimoto, Y.,, Ceccatelli, C.,, N Akanda, S Ceccatelli, F Elinder, Orrenius, S.,   +13 more
core   +1 more source

Voltage-dependent anion channels: different isoforms for different functions

, 2009
The Voltage-dependent anion channel (VDAC) is the most abundant protein of the outer mitochondrial membrane (OMM) and mediates the flow of ions and metabolites between the cytoplasm and the mitochondrial network.
DE STEFANI, Diego, De Stefani, D.
core  

Análise interactômica da VDAC (voltage-dependent anion selective channel) nos cérebros aviar, bovino e murino

Pesquisa Veterinária Brasileira, 2011
A VDAC é a proteína mais abundante na membrana mitocondrial externa. Exerce o controle da atividade desta organela através da regulação da troca de metabólitos e tem função crucial no mecanismo de apoptose.
Carla Rossini Crepaldi, Flávia Simone Munin, Phelipe Augusto Mariano Vitale, Marcelo de Cerqueira César   +3 more
doaj   +1 more source

Cysteine Oxidations in Mitochondrial Membrane Proteins: The Case of VDAC Isoforms in Mammals

Frontiers in Cell and Developmental Biology, 2020
Cysteine residues are reactive amino acids that can undergo several modifications driven by redox reagents. Mitochondria are the source of an abundant production of radical species, and it is surprising that such a large availability of highly reactive ...
Simona Reina, Maria Gaetana Giovanna Pittalà, Francesca Guarino, Angela Messina, Vito De Pinto, Salvatore Foti, Rosaria Saletti   +6 more
doaj   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, Volume 13, Issue 33, 15 June 2026.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Does the voltage dependent anion channel modulate cardiac ischemia–reperfusion injury?

, 2012
The voltage dependent anion channel (VDAC) provides exchange of metabolites, anions, and cations across the outer mitochondrial membrane. VDAC provides substrates and adenine nucleotides necessary for electron transport and therefore plays a key role in ...
Charles Steenbergen, Steenbergen, Charles, Murphy, Elizabeth, Samarjit Das, Elizabeth Murphy, Das, Samarjit   +5 more
core   +1 more source

Drosophila Porin/VDAC affects mitochondrial morphology.

PLoS ONE, 2010
Voltage-dependent anion channel (VDAC) has been suggested to be a mediator of mitochondrial-dependent cell death induced by Ca(2+) overload, oxidative stress and Bax-Bid activation.
Jeehye Park, Yongsung Kim, Sekyu Choi, Hyongjong Koh, Sang-Hee Lee, Jin-Man Kim, Jongkyeong Chung   +6 more
doaj   +1 more source

Glutathione peroxidase 3 preserves hepatocyte mitochondrial quality control to enhance macrophage pro‐regenerative phenotype during liver regeneration

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
(1) GPX3 inhibits VDAC1 oligomerisation by directly binding to it. (2) The loss of GPX3 leads to VDAC1 oligomerisation, resulting in dysregulation of mitochondrial quality control, characterised by enhanced fission, weakened fusion and impaired autophagy.
Yuechen Wang, Jian Xu, Zeyu Zhu, Ye Zhang, Haoran Hu, Yiyun Gao, Yuting Tao, Feifan Yao, Suiqing Zhou, Weizhe Zhong, Zhuqing Rao, Haoming Zhou, Xuehao Wang   +12 more
wiley   +1 more source