Results 1 to 10 of about 157,979 (315)
Hysteretic Behavior in Voltage-Gated Channels [PDF]
Frontiers in Pharmacology, 2020 An ever-growing body of evidence has shown that voltage-gated ion channels are likely molecular systems that display hysteresis in their activity. This phenomenon manifests in the form of dynamic changes in both their voltage dependence of activity and ...
Carlos A. Villalba-Galea, Alvin T. Chiem
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Genetic epilepsy with febrile seizures plus – an overview [PDF]
Romanian Journal of Neurology, 2021 Genetic epilepsy with febrile seizures plus (GEFS+) is characterized by a group of genetic epilepsies associated predominately with an autosomal dominant pattern, but also with de novo and autosomal-recessive inheritance, these last two found in a small ...
Madalina Radu +3 more
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Voltage-Gated Ion Channels [PDF]
IEEE Transactions on Nanobioscience, 2005 Voltage-dependent ion channels are membrane proteins that conduct ions at high rates regulated by the voltage across the membrane. They play a fundamental role in the generation and propagation of the nerve impulse and in cell homeostasis. The voltage sensor is a region of the protein bearing charged amino acids that relocate upon changes in the ...
Sands, Z, Grottesi, A, Sansom, MS
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The role of Phe150 in human voltage-gated proton channel
iScience, 2022 Summary: The voltage-gated proton channel Hv1 is a member of voltage-gated ion channels containing voltage-sensing domains (VSDs). The VSDs are made of four membrane-spanning segments (S1 through S4), and their function is to detect changes in membrane ...
Xin Wu, Lu Zhang, Liang Hong
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Functional reconstitution of a voltage-gated potassium channel in giant unilamellar vesicles. [PDF]
PLoS ONE, 2011 Voltage-gated ion channels are key players in cellular excitability. Recent studies suggest that their behavior can depend strongly on the membrane lipid composition and physical state. In vivo studies of membrane/channel and channel/channel interactions
Sophie Aimon +5 more
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Advances in CaV1.1 gating: New insights into permeation and voltage-sensing mechanisms
Channels, 2023 The CaV1.1 voltage-gated Ca2+ channel carries L-type Ca2+ current and is the voltage-sensor for excitation-contraction (EC) coupling in skeletal muscle.
Hugo Bibollet +3 more
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Voltage Gated Lipid Ion Channels [PDF]
Biophysical Journal, 2013 10 pages, 7 figures - Strongly revised version compared to first version.
Blicher, Andreas +1 more
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Voltage gating of mechanosensitive PIEZO channels [PDF]
Nature Communications, 2018 Abstract Mechanosensitive PIEZO ion channels are evolutionarily conserved proteins whose presence is critical for normal physiology in multicellular organisms. Here we show that, in addition to mechanical stimuli, PIEZO channels are also powerfully modulated by voltage and can even switch to a purely voltage-gated mode. Mutations that
Mirko Moroni +4 more
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The Pore of the Voltage-Gated Proton Channel [PDF]
Neuron, 2011 In classical tetrameric voltage-gated ion channels four voltage-sensing domains (VSDs), one from each subunit, control one ion permeation pathway formed by four pore domains. The human Hv1 proton channel has a different architecture, containing a VSD, but lacking a pore domain. Since its location is not known, we searched for the Hv permeation pathway.
Berger Thomas K., Isacoff Ehud Y.
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Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel
Nature Communications, 2023 Human Eag2 is a voltage-gated potassium channel with unique delayed rectifying gating kinetics. Here, authors show how voltage opens the channel and illuminate a mechanism of delayed rectifier gating.
Mingfeng Zhang +2 more
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