Results 11 to 20 of about 402,017 (293)
Voltage-gated channel mechanosensitivity: Fact or Friction?
Frontiers in Physiology, 2011 The heart is a continually active pulsatile fluid pump that generates forces by precisely timed and spaced engagement of contractile nano-machinery. This pump largely generates its own control signals, the most crucial of which involve precisely timed ...
Catherine E Morris
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Voltage-Gated Calcium Channels [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 Voltage-gated calcium (Ca(2+)) channels are key transducers of membrane potential changes into intracellular Ca(2+) transients that initiate many physiological events. There are ten members of the voltage-gated Ca(2+) channel family in mammals, and they serve distinct roles in cellular signal transduction.
W. Catterall
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LRRK2 regulates voltage-gated calcium channel function.
Frontiers in Molecular Neuroscience, 2016 Voltage-gated Ca2+ (CaV) channels enable Ca2+ influx in response to membrane depolarization. CaV2.1 channels are localized to the presynaptic membrane of many types of neurons where they are involved in triggering neurotransmitter release.
Cade eBedford +4 more
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Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2013 The crystal structure of the open conformation of a bacterial voltage-gated sodium channel pore from Magnetococcus sp. (NaVMs) has provided the basis for a molecular dynamics study defining the channel’s full ion translocation pathway and conductance ...
Bagneris, Claire +7 more
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Hysteretic Behavior in Voltage-Gated Channels
Frontiers in Pharmacology, 2020 An ever-growing body of evidence has shown that voltage-gated ion channels are likely molecular systems that display hysteresis in their activity. This phenomenon manifests in the form of dynamic changes in both their voltage dependence of activity and ...
Carlos A. Villalba-Galea, Alvin T. Chiem
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Tuning voltage-gated channel activity and cellular excitability with a sphingomyelinase
The Journal of General Physiology, 2013 Voltage-gated ion channels generate action potentials in excitable cells and help set the resting membrane potential in nonexcitable cells like lymphocytes.
D. J. Combs +4 more
semanticscholar +1 more source
Electrostatic Contributions of Aromatic Residues in the Local Anesthetic Receptor of Voltage-Gated Sodium Channels [PDF]
, 2008 Antiarrhythmics, anticonvulsants, and local anesthetics target voltage-gated sodium channels, decreasing excitability of nerve and muscle cells. Channel inhibition by members of this family of cationic, hydrophobic drugs relies on the presence of highly ...
Ahern, Christopher A. +3 more
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ATP Flux Is Controlled by a Voltage-gated Channel from the Mitochondrial Outer Membrane*
Journal of Biological Chemistry, 1996 A voltage-gated channel, called VDAC (mitochondrial porin) is known to be responsible for most of the metabolite flux across the mitochondrial outer membrane.
T. Rostovtseva, M. Colombini
semanticscholar +1 more source
Toxins, 2016 The Zoanthids are an order of cnidarians whose venoms and toxins have been poorly studied. Palythoa caribaeorum is a zoanthid commonly found around the Mexican coastline. In this study, we tested the activity of P.
Fernando Lazcano-Pérez +5 more
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eLife, 2022 Tetrameric voltage-gated K+ channels have four identical voltage sensor domains, and they regulate channel gating. KCNQ1 (Kv7.1) is a voltage-gated K+ channel, and its auxiliary subunit KCNE proteins dramatically regulate its gating.
Go Kasuya, Koichi Nakajo
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