Results 51 to 60 of about 402,017 (293)

Historical Perspective of the Characterization of Conotoxins Targeting Voltage-Gated Sodium Channels

Marine Drugs, 2023
Marine toxins have potent actions on diverse sodium ion channels regulated by transmembrane voltage (voltage-gated ion channels) or by neurotransmitters (nicotinic acetylcholine receptor channels).
James R. Groome
doaj   +1 more source

Epilepsy-Related Voltage-Gated Sodium Channelopathies: A Review

Frontiers in Pharmacology, 2020
Epilepsy is a disease characterized by abnormal brain activity and a predisposition to generate epileptic seizures, leading to neurobiological, cognitive, psychological, social, and economic impacts for the patient.
Luis Felipe Santos Menezes, Elias Ferreira Sabiá Júnior, D. Tibery, Lilian dos Anjos Carneiro, E. F. Schwartz   +4 more
semanticscholar   +1 more source

Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains [PDF]

, 2015
Voltage-gated channels open paths for ion permeation upon changes in membrane potential, but how voltage changes are coupled to gating is not entirely understood.
Barros de la Roza, Francisco, Fernández Trillo, Jorge, Gómez Posada, Juan Camilo, Leipscher, Ulrike, Loerinczi, Eva, Pardo Fernández, Luis Ángel, Peña Cortines, María del Pilar de la, Stuehmer, Walter, Tomczak, Adam P.   +8 more
core   +1 more source

Downregulation of L‐Type Voltage‐Gated Ca2+, Voltage‐Gated K+, and Large‐Conductance Ca2+‐Activated K+ Channels in Vascular Myocytes From Salt‐Loading Offspring Rats Exposed to Prenatal Hypoxia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundPrenatal hypoxia is suggested to be associated with increased risks of hypertension in offspring. This study tested whether prenatal hypoxia resulted in salt‐sensitive offspring and its related mechanisms of vascular ion channel remodeling ...
Bailin Liu, Ruixiu Shi, Xiang Li, Yanping Liu, Xueqin Feng, Xueyi Chen, Xiaorong Fan, Yingying Zhang, Wenna Zhang, Jiaqi Tang, Xiuwen Zhou, Na Li, Xiyuan Lu, Zhice Xu   +13 more
doaj   +1 more source

Characterization of voltage-gated Ca(2+) conductances in layer 5 neocortical pyramidal neurons from rats. [PDF]

PLoS ONE, 2009
Neuronal voltage-gated Ca(2+) channels are involved in electrical signalling and in converting these signals into cytoplasmic calcium changes. One important function of voltage-gated Ca(2+) channels is generating regenerative dendritic Ca(2+) spikes ...
Mara Almog, Alon Korngreen
doaj   +1 more source

Antidepressive and anxiolytic effects of ostruthin, a TREK-1 channel activator [PDF]

, 2018
We screened a library of botanical compounds purified from plants of Vietnam for modulators of the activity of a two-pore domain K+ channel, TREK-1, and we identified a hydroxycoumarin-related compound, ostruthin, as an activator of this channel ...
Joseph, Ancy, Okada, Masayoshi, Thanh, Le Tat, Thuy, Tran Thi Thu   +3 more
core   +2 more sources

Molecular basis of ion permeability in a voltage‐gated sodium channel

EMBO Journal, 2016
Voltage‐gated sodium channels are essential for electrical signalling across cell membranes. They exhibit strong selectivities for sodium ions over other cations, enabling the finely tuned cascade of events associated with action potentials.
C. Naylor, C. Bagnéris, P. DeCaen, A. Sula, Antonella Scaglione, D. Clapham, B. Wallace   +6 more
semanticscholar   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons. [PDF]

, 2016
The mechanism for the earliest response of central neurons to hypoxia-an increase in voltage-gated sodium current (INa)-has been unknown. Here, we show that hypoxia activates the Small Ubiquitin-like Modifier (SUMO) pathway in rat cerebellar granule ...
Goldstein, Steve An, Marks, Jeremy D, Plant, Leigh D   +2 more
core   +2 more sources

Multi-country Survey Revealed Prevalent and Novel F1534S Mutation in Voltage-Gated Sodium Channel (VGSC) Gene in Aedes albopictus

PLoS Neglected Tropical Diseases, 2016
Background Aedes albopictus is an important dengue vector because of its aggressive biting behavior and rapid spread out of its native home range in Southeast Asia.
Jiabao Xu, M. Bonizzoni, Daibin Zhong, Guofa Zhou, Songwu Cai, Yiji Li, Xiaoming Wang, Eugenia Lo, Rebecca Lee, Roger Sheen, J. Duan, G. Yan, Xiao-Guang Chen   +12 more
semanticscholar   +1 more source