Results 51 to 60 of about 238,298 (223)

Voltage-Gated Potassium Channels as Regulators of Cell Death

Frontiers in Cell and Developmental Biology, 2020
Ion channels allow the flux of specific ions across biological membranes, thereby determining ion homeostasis within the cells. Voltage-gated potassium-selective ion channels crucially contribute to the setting of the plasma membrane potential, to volume
Magdalena Bachmann, Magdalena Bachmann, Weiwei Li, Michael J. Edwards, Syed A. Ahmad, Sameer Patel, Ildiko Szabo, Ildiko Szabo, Erich Gulbins, Erich Gulbins   +9 more
doaj   +1 more source

Comparison of Langevin and Markov channel noise models for neuronal signal generation

, 2009
The stochastic opening and closing of voltage-gated ion channels produces noise in neurons. The effect of this noise on the neuronal performance has been modelled using either approximate or Langevin model, based on stochastic differential equations or ...
A. L. Hodgkin, B. Sengupta, C. P. Fall, C. W. Gardiner, E. M. Izhikevich, F. Rieke, G. Marsaglia, J. C. Roddey, J. E. McGeoch, J. E. Niven, J. S. Bendat, P. E. Kloeden, S. B. Laughlin, T. M. Cover, W. Gerstner, W. H. Press   +15 more
core   +1 more source

Emerging Roles of L-Type Voltage-Gated and Other Calcium Channels in T Lymphocytes [PDF]

, 2013
In T lymphocytes, calcium ion controls a variety of biological processes including development, survival, proliferation, and effector functions. These distinct and specific roles are regulated by different calcium signals, which are generated by various ...
Abdallah eBadou, Didi eMatza, Mithilesh K. Jha, Richard A. Flavell, Richard A. Flavell   +4 more
core   +2 more sources

Voltage-Gated Ion Channels and Electrical Excitability [PDF]

Neuron, 1998
Our original research has been generously supported over many years by National Institutes of Health grants NS08174 and NS12547.
Armstrong, Clay M, Hille, Bertil
openaire   +2 more sources

Spike propagation through the dorsal root ganglia in an unmyelinated sensory neuron: a modeling study [PDF]

, 2015
Unmyelinated C-fibers are a major type of sensory neurons conveying pain information. Action potential conduction is regulated by the bifurcation (T-junction) of sensory neuron axons within the dorsal root ganglia (DRG).
Borg-Graham LJ, Danielle Sundt, David B. Jaffe, Hendry SHC, Nikita Gamper, Waxman SG, Yamada W   +6 more
core   +1 more source

Monte Carlo simulation for statistical mechanics model of ion channel cooperativity in cell membranes

, 2008
Voltage-gated ion channels are key molecules for the generation and propagation of electrical signals in excitable cell membranes. The voltage-dependent switching of these channels between conducting and nonconducting states is a major factor in ...
A. L. Hodgkin, A. V. Hill, B. Hille, D. J. Aidley, Ekrem Aydiner, P. Ghosh, Riza Erdem   +6 more
core   +1 more source

Maturation of NaV and KV channel topographies in the auditory nerve spike initiator before and after developmental onset of hearing function [PDF]

, 2016
Auditory nerve excitation and thus hearing depend on spike-generating ion channels and their placement along the axons of auditory nerve fibers (ANFs).
Kim, Kyunghee X, Rutherford, Mark A
core   +2 more sources

Potential roles of voltage-gated ion channel disruption in Tuberous Sclerosis Complex

Frontiers in Molecular Neuroscience
Tuberous Sclerosis Complex (TSC) is a lynchpin disorder, as it results in overactive mammalian target of rapamycin (mTOR) signaling, which has been implicated in a multitude of disease states.
Hailey X. Egido-Betancourt, Roy E. Strowd III, Kimberly F. Raab-Graham   +2 more
doaj   +1 more source

Activity of Palythoa caribaeorum Venom on Voltage-Gated Ion Channels in Mammalian Superior Cervical Ganglion Neurons

Toxins, 2016
The Zoanthids are an order of cnidarians whose venoms and toxins have been poorly studied. Palythoa caribaeorum is a zoanthid commonly found around the Mexican coastline. In this study, we tested the activity of P.
Fernando Lazcano-Pérez, Héctor Castro, Isabel Arenas, David E. García, Ricardo González-Muñoz, Roberto Arreguín-Espinosa   +5 more
doaj   +1 more source

Structural modeling of ion channels using AlphaFold2, RoseTTAFold2, and ESMFold

Channels
Ion channels play key roles in human physiology and are important targets in drug discovery. The atomic-scale structures of ion channels provide invaluable insights into a fundamental understanding of the molecular mechanisms of channel gating and ...
Phuong Tran Nguyen, Brandon John Harris, Diego Lopez Mateos, Adriana Hernández González, Adam Michael Murray, Vladimir Yarov-Yarovoy   +5 more
doaj   +1 more source