Cryo-EM structure of the KvAP channel reveals a non-domain-swapped voltage sensor topology
eLife, 2019 Conductance in voltage-gated ion channels is regulated by membrane voltage through structural domains known as voltage sensors. A single structural class of voltage sensor domain exists, but two different modes of voltage sensor attachment to the pore ...
Xiao Tao, Roderick MacKinnon
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Control of protein phosphatase I in the dendrite [PDF]
, 1999 Communication between nerve cells is mediated by both electrical and chemical signals. Chemical neurotransmission can be further categorized into fast and slow components.
Allen, P. B. +5 more
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Voltage- and calcium-gated ion channels of neurons in the vertebrate retina.
Progress in retinal and eye research, 2019 In this review, we summarize studies investigating the types and distribution of voltage- and calcium-gated ion channels in the different classes of retinal neurons: rods, cones, horizontal cells, bipolar cells, amacrine cells, interplexiform cells, and ...
M. V. Van Hook, S. Nawy, W. Thoreson
semanticscholar +1 more source
Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior [PDF]
, 2006 The S100 family protein p11 (S100A10, annexin 2 light chain) is involved in the trafficking of the voltage-gated sodium channel Na(V)1.8, TWIK-related acid-sensitive K+ channel (TASK-1), the ligand-gated ion channels acid-sensing ion channel 1a (ASIC1a ...
Baker, MD +8 more
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Marine Toxins Targeting Ion Channels
Marine Drugs, 2006 : This introductory minireview points out the importance of ion channels for cell communication. The basic concepts on the structure and function of ion channels triggered by membrane voltage changes, the so-called voltage-gated ion channels (VGICs), as ...
Hugo R. Arias
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KCNQs: Ligand- and Voltage-Gated Potassium Channels
Frontiers in Physiology, 2020 Voltage-gated potassium (Kv) channels in the KCNQ (Kv7) family are essential features of a broad range of excitable and non-excitable cell types and are found in organisms ranging from Hydra vulgaris to Homo sapiens.
Geoffrey W. Abbott
doaj +1 more source
Mechanism of activation at the selectivity filter of the KcsA K(+) channel [PDF]
, 2017 Potassium channels are opened by ligands and/or membrane potential. In voltage-gated K(+) channels and the prokaryotic KcsA channel, conduction is believed to result from opening of an intracellular constriction that prevents ion entry into the pore.
Aqvist +60 more
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Voltage-gated ion channels and gating modifier toxins.
Toxicon, 2007 Voltage-gated sodium, calcium, and potassium channels generate electrical signals required for action potential generation and conduction and are the molecular targets for a broad range of potent neurotoxins.
W. Catterall +5 more
semanticscholar +1 more source
Advances in the role of intestinal ion channels in the pathogenesis of irritable bowel syndrome [PDF]
Jichu yixue yu linchuang, 2020 Ion channels are widely present in mucous membranes of the digestive tract, their abnormal expression and(or) function are important pathogenic mechanisms of irritable bowel syndrome (IBS).
LAN Fei, LIU Tai-yang, YANG Jie
doaj
Genetics update: monogenetics, polygene disorders and the quest for modifying genes [PDF]
, 2018 The genetic channelopathies are a broad collection of diseases. Many ion channel genes demonstrate wide phenotypic pleiotropy, but nonetheless concerted efforts have been made to characterise genotype-phenotype relationships.
Symonds, Joseph D., Zuberi, Sameer M.
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