Results 121 to 130 of about 2,245,116 (239)

Ultrathin Membrane With Ion‐Specific Gating Enables Interfacial Decoupling of Conductivity–Selectivity for Aqueous Flow Batteries

Angewandte Chemie, EarlyView.
An interfacial ion‐specific gating strategy shifts membrane design from ion diffusion within ion‐exchange channels to ion partitioning at the membrane–electrolyte interface, thereby decoupling selectivity from conductivity. The strategy underscores the pivotal yet underexplored role of the membrane–electrolyte interface, providing a broadly applicable ...
Di Mu, Yu Xiong, Feiran Wang, Jiafeng Lei, Fei Ai, Jun Fan, Yi‐Chun Lu   +6 more
wiley   +2 more sources

Reduction of inflammation and mitochondrial degeneration in mutant SOD1 mice through inhibition of voltage-gated potassium channel Kv1.3. [PDF]

Front Mol Neurosci, 2023
Ratano P, Cocozza G, Pinchera C, Busdraghi LM, Cantando I, Martinello K, Scioli M, Rosito M, Bezzi P, Fucile S, Wulff H, Limatola C, D'Alessandro G.   +12 more
europepmc   +1 more source

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

Advanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng, Xiaqing Lin, Hongyu Yao, Cheng Li, Huabao Liao, Yuexin Liu, Boxu Cao, Xue‑Jun Song   +7 more
wiley   +1 more source

Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators

Angewandte Chemie, EarlyView.
The paper describes the serendipitous discovery of chemical manipulation allowing the activator‐to‐inhibitor switching in Kv7.2 channel modulators. The molecular determinants driving this switch have been rationalized by multidisciplinary investigation encompassing synthetic and analytical chemistry, in silico methods, cryo‐EM analysis ...
Tania Ciaglia, Giusy Carleo, Zhenni Yang, Francesca Di Matteo, Federica De Rosa, Gerardina Smaldone, Zhao‐Bing Gao, Marco D'Alì, Rita Turcio, Demin Ma, Veronica Di Sarno, Nannan Su, Salvatore Vincenzo Giofrè, Giacomo Pepe, Pietro Campiglia, Alessia Bertamino, Francesco Miceli, Jiangtao Guo, Nunzio Iraci, Carmine Ostacolo, Maurizio Taglialatela   +20 more
wiley   +2 more sources

Synthetic cannabinoid receptor agonists inhibit the cardiac voltage-gated potassium channel hERG. [PDF]

Acta Pharmacol Sin
Ottosson NE, Frampton DJA, Pipatpolkai T, Norman C, Karlsson U, Jauregi-Miguel A, Venter M, Sridhar A, Larsson HP, Gréen H, Liin SI.   +10 more
europepmc   +2 more sources

Intracellular hemin is a potent inhibitor of the voltage-gated potassium channel Kv10.1. [PDF]

Sci Rep, 2022
Sahoo N, Yang K, Coburger I, Bernert A, Swain SM, Gessner G, Kappl R, Kühl T, Imhof D, Hoshi T, Schönherr R, Heinemann SH.   +11 more
europepmc   +1 more source

Electrically Tuning Electromagnetic Wave Shielding in Phase Engineered 1T/2H‐MoS2‐Based Devices

Advanced Electronic Materials, EarlyView.
Sub‐millimeter‐thick phase‐engineered 1T/2H‐MoS2 structures enable electrically tunable electromagnetic interference shielding through active modulation of microwave absorption and reflection. The coexistence of metallic and semiconducting phases, combined with a PVA/KOH gel electrolyte, provides dynamic control over charge transport and interfacial ...
Mustafa Akyol, Atalay Bozdogan, Hakan Eroglu, Muharrem Karaaslan   +3 more
wiley   +1 more source

Integrated analysis of the voltage-gated potassium channel-associated gene KCNH2 across cancers. [PDF]

BMC Bioinformatics, 2023
Zheng Z, Song Y.
europepmc   +1 more source

Smart Exploration of Perovskite Photovoltaics: From AI Driven Discovery to Autonomous Laboratories

Advanced Energy Materials, EarlyView.
In this review, we summarize the fundamentals of AI in automated materials science, and review AI applications in perovskite solar cells. Then, we sum up recent progress in AI‐guided manufacturing optimization, and highlight AI‐driven high‐throughput and autonomous laboratories.
Wenning Chen, Zheyu Zhang, Kelvian T. Mularso, Bonghyun Jo, Hyun Suk Jung   +4 more
wiley   +1 more source

Inhibition of the voltage-gated potassium channel Kv1.5 by hydrogen sulfide attenuates remodeling through S-nitrosylation-mediated signaling. [PDF]

Commun Biol, 2023
Al-Owais MM, Hettiarachchi NT, Dallas ML, Scragg JL, Lippiat JD, Holden AV, Steele DS, Peers C.   +7 more
europepmc   +1 more source