Voltage-Gated Sodium Channel Dysfunctions in Neurological Disorders [PDF]
Life, 2023 The pore-forming subunits (α subunits) of voltage-gated sodium channels (VGSC) are encoded in humans by a family of nine highly conserved genes. Among them, SCN1A, SCN2A, SCN3A, and SCN8A are primarily expressed in the central nervous system. The encoded
Raffaella Barbieri +4 more
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Differential lipid dependence of the function of bacterial sodium channels. [PDF]
PLoS ONE, 2013 The lipid bilayer is important for maintaining the integrity of cellular compartments and plays a vital role in providing the hydrophobic and charged interactions necessary for membrane protein structure, conformational flexibility and function.
Nazzareno D'Avanzo +5 more
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Voltage-Gated Sodium Channel Inhibition by µ-Conotoxins [PDF]
Toxinsµ-Conotoxins are small, potent pore-blocker inhibitors of voltage-gated sodium (NaV) channels, which have been identified as pharmacological probes and putative leads for analgesic development.
Kirsten L. McMahon +2 more
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Sodium channels and mammalian sensory mechanotransduction [PDF]
Molecular Pain, 2012 Background Members of the degenerin/epithelial (DEG/ENaC) sodium channel family are mechanosensors in C elegans, and Nav1.7 and Nav1.8 voltage-gated sodium channel knockout mice have major deficits in mechanosensation. β and γENaC sodium channel subunits
Raouf Ramin +7 more
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Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel [PDF]
eLife, 2023 Voltage-gated ion channels (VGICs) orchestrate electrical activities that drive mechanical functions in contractile tissues such as the heart and gut. In turn, contractions change membrane tension and impact ion channels.
Peter R Strege +7 more
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Voltage-Gated Sodium Channel Dysfunction in Epilepsy: Zebrafish Models for Therapeutics [PDF]
BiomedicinesVoltage-gated sodium channels (VGSCs) play pivotal roles in cellular function, particularly in the regulation of electrical signaling. Structural defects in these channels cause deleterious effects in a myriad of cell types, leading to various diseases ...
Angela Gyamfi +4 more
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Determining the structure of the bacterial voltage-gated sodium channel NaChBac embedded in liposomes by cryo electron tomography and subtomogram averaging [PDF]
Scientific Reports, 2023 Voltage-gated sodium channels shape action potentials that propagate signals along cells. When the membrane potential reaches a certain threshold, the channels open and allow sodium ions to flow through the membrane depolarizing it, followed by the ...
Shih-Ying Scott Chang +3 more
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Structural mechanism of voltage-gated sodium channel slow inactivation [PDF]
Nature CommunicationsVoltage-gated sodium (NaV) channels mediate a plethora of electrical activities. NaV channels govern cellular excitability in response to depolarizing stimuli.
Huiwen Chen +11 more
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Bisphenol A binds to the local anesthetic receptor site to block the human cardiac sodium channel. [PDF]
PLoS ONE, 2012 Bisphenol A (BPA) has attracted considerable public attention as it leaches from plastic used in food containers, is detectable in human fluids and recent epidemiologic studies link BPA exposure with diseases including cardiovascular disorders.
Andrias O O'Reilly +5 more
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Genetic epilepsy with febrile seizures plus – an overview [PDF]
Romanian Journal of Neurology, 2021 Genetic epilepsy with febrile seizures plus (GEFS+) is characterized by a group of genetic epilepsies associated predominately with an autosomal dominant pattern, but also with de novo and autosomal-recessive inheritance, these last two found in a small ...
Madalina Radu +3 more
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