Results 31 to 40 of about 115,275 (296)

Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates. [PDF]

PLoS Genetics, 2008
In many mammalian neurons, dense clusters of ion channels at the axonal initial segment and nodes of Ranvier underlie action potential generation and rapid conduction.
Alexis S Hill, Atsuo Nishino, Koichi Nakajo, Giuxin Zhang, Jaime R Fineman, Michael E Selzer, Yasushi Okamura, Edward C Cooper   +7 more
doaj   +1 more source

The role of Nav1.9 channel in the development of neuropathic orofacial pain associated with trigeminal neuralgia [PDF]

, 2015
BACKGROUND: Trigeminal neuralgia is accompanied by severe mechanical, thermal and chemical hypersensitivity of the orofacial area innervated by neurons of trigeminal ganglion (TG).
Kopach, O, Luiz, AP, Santana-Varela, S, Wood, JN   +3 more
core   +1 more source

Interpreting the functional role of a novel interaction motif in prokaryotic sodium channels [PDF]

, 2017
Voltage-gated sodium channels enable the translocation of sodium ions across cell membranes and play crucial roles in electrical signaling by initiating the action potential.
Ahern, Ahuja, Altin Sula, Arrigoni, B.A. Wallace, Bagnéris, Bagnéris, Charalambous, DeCaen, DeCaen, Depienne, Fukuma, Gardella, Hille, Ito, Kapplinger, Koishi, Lenaeus, Li, McCusker, McNicholas, Mio, Naylor, Oelstrom, Payandeh, Payandeh, Powl, Qu, Ren, Shaya, Shen, Smart, Sula, Tang, Ulmschneider, Villalba-Galea, Zhang   +36 more
core   +1 more source

Functional correlates of clinical phenotype and severity in recurrent SCN2A variants

Communications Biology, 2022
A comprehensive biophysical analysis of disease-associated mutations in the voltage-gated sodium channel gene, SCN2A, suggests that dynamic action potential clamp may be a better predictor than voltage clamp of how these mutations alter neuronal ...
Géza Berecki, Katherine B. Howell, Jacqueline Heighway, Nelson Olivier, Jill Rodda, Isabella Overmars, Danique R. M. Vlaskamp, Tyson L. Ware, Simone Ardern-Holmes, Gaetan Lesca, Michael Alber, Pierangelo Veggiotti, Ingrid E. Scheffer, Samuel F. Berkovic, Markus Wolff, Steven Petrou   +15 more
doaj   +1 more source

Lipid ion channels and the role of proteins [PDF]

, 2013
Synthetic lipid membranes in the absence of proteins can display quantized conduction events for ions that are virtually indistinguishable from those of protein channel. By indistinguishable we mean that one cannot decide based on the current trace alone
Heimburg, Thomas, Mosgaard, Lars D.
core   +1 more source

Genetics update: monogenetics, polygene disorders and the quest for modifying genes [PDF]

, 2018
The genetic channelopathies are a broad collection of diseases. Many ion channel genes demonstrate wide phenotypic pleiotropy, but nonetheless concerted efforts have been made to characterise genotype-phenotype relationships.
Symonds, Joseph D., Zuberi, Sameer M.
core   +1 more source

Voltage-Gated Sodium Channels: A Therapeutic Target in Ischemic Heart Disease

Reviews in Cardiovascular Medicine
Myocardial infarction (MI)-related arrhythmias are an essential risk factor in sudden cardiac death. Aberrant cardiac the cardiac voltage-gated sodium channel (Nav1.5) is important in the development of ventricular arrhythmias after an MI.
Xiao-Lu Zhang, Tian-Peng Wei, Fan Yang, Huan-Huan Liu, Ling-Ling Qian, Ru-Xing Wang   +5 more
doaj   +1 more source

An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels [PDF]

, 2015
Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials.
Beltran-Alvarez, Pedro, Onwuli, Donatus O.   +1 more
core   +1 more source

A numerical approach to ion channel modelling using whole-cell voltage-clamp recordings and a genetic algorithm.

PLoS Computational Biology, 2007
The activity of trans-membrane proteins such as ion channels is the essence of neuronal transmission. The currently most accurate method for determining ion channel kinetic mechanisms is single-channel recording and analysis.
Meron Gurkiewicz, Alon Korngreen
doaj   +1 more source

Voltage-gated sodium channels dysfunction in depression: the hypothesis

Psychiatry and Behavioral Sciences, 2016
Voltage-gated sodium (Na+) channels (VGSCs) are responsible for action potential initiation and propagation in most electrically excitable cells which are implicated in a wide range physiological functions including neuronal signalling, muscle ...
Osman Ozdemir
doaj   +1 more source