Results 91 to 100 of about 62,302 (192)
, 2010 The beta subunit of high voltage-activated Ca (Cav) channels targets the pore forming [alpha]~1~ subunit to the plasma membrane and defines the biophysical phenotype of the Cav channel complex. Cav channel inactivation following activation and opening is
Robert M. Greenberg +1 more
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Potassium channels in prostate and colonic cancer
, 2007 Large conductance Ca2+-activated K+ channels in human prostate cancer The KCNMA1 gene encoding the alpha-subunit of BK channels is amplified and BK channel expression is enhanced in late-stage, metastatic and hormone-refractory human prostate cancer ...
Ousingsawat, Jiraporn
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Postsynaptic protein kinase a reduces neuronal excitability in response to increased synaptic excitation in the Drosophila CNS [PDF]
, 2003 Previous work has identified a role for synaptic activity in the development of excitable properties of motoneurons in the Drosophila embryo. In this study the underlying mechanism that enables two such neurons, termed aCC and RP2, to respond to ...
Baines, Richard A.; id_orcid +1 more
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Journal of Venomous Animals and Toxins including Tropical DiseasesSpider venoms are known to contain proteins and polypeptides that perform various functions including antimicrobial, neurotoxic, analgesic, cytotoxic, necrotic, and hemagglutinic activities.
Ting Wu +6 more
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Evolution of voltage-gated sodium channels
, 2013 Voltage-gated sodium channels play important roles in the nervous system by enabling propagation of action potentials along axons. It has been suggested that sodium channels evolved from calcium channels before the split of animals and choanoflagellates,
Widmark, Jenny,, Larhammar, Dan,
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Phosphoinositide regulation of voltage-gated sodium channels. [PDF]
J Gen Physiol, 2023 Short B.
europepmc +1 more source
Kinetic model based on molecular mechanism for action potential
, 2011 The Hodgkin-Huxley model for action potentials has been widely used but was not built on a microscopic description of the neuronal membrane. Through molecular dynamics simulations, the molecular mechanism of the channel currents is becoming clear ...
Lizhong Xu
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Trifunctional Saxitoxin Conjugates for Covalent Labeling of Voltage-Gated Sodium Channels. [PDF]
Chembiochem, 2023 Finkelstein DS, Du Bois J.
europepmc +1 more source
State-Dependent Actions Of Sodium Channel Inhibitor Insecticides On Mammalian Voltage-Gated Sodium Channels [PDF]
, 2011 Sodium channel inhibitor insecticides are an emerging class of neurotoxic insect control agents that selectively inhibit voltage-gated sodium channels at membrane potentials that promote slow sodium channel inactivation.
Von Stein, Richard
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Voltage gated sodium channels as therapeutic targets for chronic pain
Journal of Pain Research, 2019 Renee Siu Yu Ma,1 Kayani Kayani,1 Danniella Whyte-Oshodi,1 Aiyesha Whyte-Oshodi,2 Nitish Nachiappan,3 Shaene Gnanarajah,1 Raihan Mohammed1 1Department of Medicine, University of Cambridge, Cambridge, UK; 2Faculty of Medicine,
Ma RSY +6 more
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