Results 11 to 20 of about 2,601,766 (241)

Voltage-gated sodium channels in cancers [PDF]

Biomarker Research
Voltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of cancers, derived from “non-excitable” tissues that do not generate ...
Hengrui Liu, Jieling Weng, Christopher L.-H. Huang, Antony P. Jackson   +3 more
doaj   +2 more sources

Beyond CBD: Inhibitory effects of lesser studied phytocannabinoids on human voltage-gated sodium channels [PDF]

Frontiers in Physiology, 2023
Introduction: Cannabis contains cannabidiol (CBD), the main non-psychoactive phytocannabinoid, but also many other phytocannabinoids that have therapeutic potential in the treatment of epilepsy.
Carol J. Milligan, Lyndsey L. Anderson, Lyndsey L. Anderson, Lyndsey L. Anderson, Iain S. McGregor, Iain S. McGregor, Iain S. McGregor, Jonathon C. Arnold, Jonathon C. Arnold, Jonathon C. Arnold, Steven Petrou, Steven Petrou   +11 more
doaj   +2 more sources

Differential encoding of mammalian proprioception by voltage-gated sodium channels [PDF]

Sci Adv
Supplemental Data and Videos for "Differential encoding of mammalian proprioception by voltage-gated sodium channels"THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE.
Espino, Cyrrus, Espino, C (via Mendeley Data)   +1 more
core   +2 more sources

Inhibition of Voltage-Gated Sodium Channels by Animal Toxins [PDF]

Structural Dynamics
Voltage-gated sodium channels (NaVs) play important roles in propagating action potentials and their structure and function can be modulated by a variety of factors, including animal toxins.
Shane Gonen
doaj   +2 more sources

Voltage-gated sodium channels in the nervous system: Molecular physiology to therapeutic interventions [PDF]

Neural Regeneration Research
Voltage-gated sodium channels are essential ionic-conductance pathways in the nervous system, which play an irreplaceable role in modulating neuronal excitability and signal transduction.
Ni Li, Lin Yan, Anna Peng, Xuefei Fu, Huan Qin, Kai Yao   +5 more
doaj   +2 more sources

Neuromodulation of voltage-gated sodium channels by Gβ1γ2 subunits: Implications for GNB1-linked encephalopathy [PDF]

Neurobiology of Disease
Summary: Guanine nucleotide-binding protein Gβγ subunits are ubiquitous signaling molecules that interact with numerous effector proteins in neurons, including voltage-gated sodium, calcium, and potassium channels.
Nicholas Denomme, Samantha L. Hodges, Luis Lopez-Santiago, Yukun Yuan, Julie M. Ziobro, Joe Minton, Chunling Chen, Yan Chen, Jacob M. Hull, James Offord, Alan V. Smrcka, Lori L. Isom   +11 more
doaj   +2 more sources

Drug binding sites on Nat1.8 sodium channels [PDF]

, 2008
The voltage-gated sodium channel, Nav 1.8, is known to play an important role in pain signalling. In this thesis, the functional properties and drug binding sites of wild type and mutant Nav 1.8 sodium channel currents were studied in mammalian sensory ...
Browne, Liam Edward
core   +6 more sources

Light-Induced Control of Voltage Gated Ion Channels [PDF]

, 2022
Voltage gated ion channels are transmembrane proteins responsible for the generation and propagation of action potentials in excitable cells. They are key targets in receptor pharmacology, since the simple actions of opening and closing their pore with ...
Shirin, Faraji, Vito F., Palmisano, Nuria, Anguita-Ortiz, Juan Jose, Nogueira, Juan Jose Nogueira, Shirin Faraji, Vito F. Palmisano, Nuria Anguita-Ortiz   +7 more
core   +1 more source

Role of the C-terminal domain in the structure and function of tetrameric sodium channels [PDF]

, 2013
Voltage-gated sodium channels have essential roles in electrical signalling. Prokaryotic sodium channels are tetramers consisting of transmembrane (TM) voltage-sensing and pore domains, and a cytoplasmic carboxy-terminal domain.
Clapham, D.E., Hall, Benjamin A., Wallace, Bonnie A., Claire E. Naylor, Christopher W. M. Kay, Paul G. Decaen, Clapham, David, Hall, B.A., Wallace, B. A., DeCaen, P.G., Naylor, Claire E., Benjamin A. Hall, B. A. Wallace, Bagneris, Claire, Kay, C.W.M., DeCaen, Paul, David E. Clapham, Kay, Christopher W. M.   +17 more
core   +2 more sources

Regulation of pain neurotransmitters and chondrocytes metabolism mediated by voltage-gated ion channels: A narrative review

Heliyon, 2023
Osteoarthritis (OA) is one of the leading causes of chronic pain and dysfunction. It is essential to comprehend the nature of pain and cartilage degeneration and its influencing factors on OA treatment. Voltage-gated ion channels (VGICs) are essential in
Xinwei Wang, Xueping Li
doaj   +1 more source