Results 81 to 90 of about 2,601,766 (241)

Potential roles of voltage-gated ion channel disruption in Tuberous Sclerosis Complex

Frontiers in Molecular Neuroscience
Tuberous Sclerosis Complex (TSC) is a lynchpin disorder, as it results in overactive mammalian target of rapamycin (mTOR) signaling, which has been implicated in a multitude of disease states.
Hailey X. Egido-Betancourt, Roy E. Strowd III, Kimberly F. Raab-Graham   +2 more
doaj   +1 more source

Sodium channels and mammalian sensory mechanotransduction

Molecular Pain, 2012
Background Members of the degenerin/epithelial (DEG/ENaC) sodium channel family are mechanosensors in C elegans, and Nav1.7 and Nav1.8 voltage-gated sodium channel knockout mice have major deficits in mechanosensation. β and γENaC sodium channel subunits
Raouf Ramin, Rugiero Francois, Kiesewetter Hannes, Hatch Rachel, Hummler Edith, Nassar Mohammed A, Wang Fan, Wood John N   +7 more
doaj   +1 more source

Advances in Bio‐Integrated Edge Computing Systems for Smart and Connected Health

Advanced Materials, EarlyView.
This review explores advances in bio‐integrated edge computing for healthcare, focusing on co‐designing computing, sensing, and energy strategies to overcome integration and power challenges for optimized, decentralized operation. ABSTRACT Recent advances in bio‐integrated healthcare technologies have enabled continuous, high‐resolution monitoring and ...
Gyuwon Kim, Seungwon Yoo, Tae Woog Kang, Yunuo Huang, Woon‐Hong Yeo   +4 more
wiley   +1 more source

Propranolol blocks cardiac and neuronal voltage-gated sodium channels

Frontiers in Pharmacology, 2010
Propranolol is a widely-used, nonselective ß-adrenergic receptor antagonist with proven efficacy in treating cardiovascular disorders and in the prevention of migraine headaches.
Dao W Wang, Dao W Wang, Akshitkumar M Mistry, Kristopher M Kahlig, Jennifer A Kearney, Jizhou eXiang, Alfred L George, Alfred L George   +7 more
doaj   +1 more source

Bacteria‐Trained, MnO2‐Armored Dendritic Cells for Immunotherapy

Advanced Materials, EarlyView.
MnO2‐armored, bacteria‐trained dendritic cells undergo tumor‐responsive mechanical and immunological transformation. The nanocoating masks immune ligands and maintains a mechanically stiff, quiescent state during circulation, while the tumor microenvironment removes the armor and restores cellular deformability and immune accessibility.
Zhao Guo, Min Ge, Zesong Ruan, Tingwang Shi, Mahyar Mahmoudi, Soohwan An, Na Kong, Yunfeng Chen, Han Lin, Wei Tao   +9 more
wiley   +1 more source

Structural modeling of ion channels using AlphaFold2, RoseTTAFold2, and ESMFold

Channels
Ion channels play key roles in human physiology and are important targets in drug discovery. The atomic-scale structures of ion channels provide invaluable insights into a fundamental understanding of the molecular mechanisms of channel gating and ...
Phuong Tran Nguyen, Brandon John Harris, Diego Lopez Mateos, Adriana Hernández González, Adam Michael Murray, Vladimir Yarov-Yarovoy   +5 more
doaj   +1 more source

Life‐Like Ferrous Oxide Microspheres from Kombucha

Advanced Materials Interfaces, EarlyView.
Kombucha bacterial cellulose, sodium alginate, and ferrous nitrate self‐assemble into membrane‐enclosed iron oxide microspheres. These microspheres bud daughter vesicles, sustain 24‐h electrochemical oscillations, and filter theta‐band signals.
Panagiotis Mougkogiannis, Anna Nikolaidou, Andrew Adamatzky   +2 more
wiley   +1 more source

Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus

eLife, 2014
Entry and extrusion of cations are essential processes in living cells. In alkaliphilic prokaryotes, high external pH activates voltage-gated sodium channels (Nav), which allows Na+ to enter and be used as substrate for cation/proton antiporters ...
Paul G DeCaen, Yuka Takahashi, Terry A Krulwich, Masahiro Ito, David E Clapham   +4 more
doaj   +1 more source

Predictive 3D modelling of the interactions of pyrethroids with the voltage-gated sodium channels of ticks and mites

, 2014
Background: The pyrethroid insecticides are a very successful group of compounds that target invertebrate voltage-gated sodium channels and are widely used in the control of insects, ticks and mites.
Field, L.M., Williamson, M.S., González-Cabrera, J., Wallace, Bonnie A., Gozalez-Cabrera, J., Wallace, B. A., Turberg, A., Emyr Davies, T.G., Field, L. M., O'Reilly, A.O., O'Reilly, A. O., Davies, T. G. E., Williamson, M. S., Davies, Emyr, Williamson, Martin, Field, Lin   +15 more
core   +1 more source

Highly Conductive and Transparent Coatings via Low‐Temperature Hydroiodic Acid Vapor Treatment of Oxo‐Graphene Thin Films

Advanced Materials Technologies, EarlyView.
The double self‐assembly (DSA) method applied to oxo‐graphene (oxo‐G) flakes followed by hydroiodic acid (HI) vapor treatment and low‐temperature annealing yields highly conductive, optically transparent thin films with the potential for applications in electronic and optoelectronic devices.
Arindam Konar, David Kaiser, Guobin Jia, Hamid Reza Rasouli, Janis Köster, Christof Neumann, Andrea Dellith, Uwe Hübner, Christian E. Halbig, Siegfried Eigler, Ute Kaiser, Benjamin Dietzek‐Ivanšić, Jonathan Plentz, Andrey Turchanin   +13 more
wiley   +1 more source