Results 21 to 30 of about 57,572 (247)

Voltage-gated sodium channels: biophysics, pharmacology, and related channelopathies

Frontiers in Pharmacology, 2012
Voltage-gated sodium channels (VGSC) are multi-molecular protein complexes expressed in both excitable and non-excitable cells. They are primarily formed by a pore-forming multi-spanning integral membrane glycoprotein (α-subunit) that can be associated ...
Eleonora eSavio Galimberti, Michael eGollob, Dawood eDarbar   +2 more
doaj   +3 more sources

The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional Implications and Regulatory Mechanisms

Frontiers in Cellular Neuroscience, 2017
Neurons are highly polarized cells with apparent functional and morphological differences between dendrites and axon. A critical determinant for the molecular and functional identity of axonal and dendritic segments is the restricted expression of ...
Jeffrey Lopez-Rojas, Maël Duménieu, Marie Oulé, Michael R. Kreutz, Michael R. Kreutz   +4 more
doaj   +3 more sources

Druggability of Voltage-Gated Sodium Channels—Exploring Old and New Drug Receptor Sites

Frontiers in Pharmacology, 2022
Voltage-gated ion channels are important drug targets because they play crucial physiological roles in both excitable and non-excitable cells. About 15% of clinical drugs used for treating human diseases target ion channels.
Goragot Wisedchaisri, Tamer M. Gamal El-Din   +1 more
doaj   +1 more source

Unmasking of Brugada syndrome by lamotrigine in a patient with pre-existing epilepsy: A case report with review of the literature

Frontiers in Cardiovascular Medicine, 2022
Brugada syndrome is an inherited cardiac channelopathy arising from mutations in voltage-gated cardiac sodium channels. Idiopathic epilepsy portrays a coalescent underlying pathophysiological mechanism pertaining to the premature excitation of neuronal ...
Hafiz Omer, Hafiz Omer, Mohamed H. Omer, Abdulmohsen R. Alyousef, Ali M. Alzammam, Omar Ahmad, Haitham A. Alanazi, Haitham A. Alanazi, Haitham A. Alanazi   +8 more
doaj   +1 more source

Nomenclature of Voltage-Gated Sodium Channels [PDF]

Neuron, 2000
Voltage-gated Ca2+ channels mediate calcium influx in response to membrane depolarization and regulate intracellular processes such as contraction, secretion, neurotransmission, and gene expression. They are members of a gene superfamily of transmembrane ion channel proteins that includes voltage-gated K+ and Na+ channels.
Goldin, Alan L., Barchi, Robert L., Caldwell, John H., Hofmann, Franz, Howe, James R., Hunter, John C., Kallen, Roland G., Mandel, Gail, Meisler, Miriam H., Netter, Yoheved Berwald, Noda, Masahara, Tamkun, Michael M., Waxman, Steven G., Wood, John N., Catterall, William A.   +14 more
openaire   +2 more sources

Voltage-gated sodium channels gene expression in Burning Mouth Syndrome: a case-control study

Brazilian Oral Research, 2023
Burning mouth syndrome (BMS) is a condition characterized by painful symptoms of the oral mucosa, despite the absence of any clinical signs. Its etiology is unknown, and there is still no effective treatment to date.
Carina DOMANESCHI, Vanessa Juliana Gomes CARVALHO, Bruno Munhoz MAROTTA, Norberto Nobuo SUGAYA, Fábio Daumas NUNES, Camila de Barros GALLO   +5 more
doaj   +1 more source

The crystal structure of a voltage-gated sodium channel [PDF]

Nature, 2011
Voltage-gated sodium (Na(V)) channels initiate electrical signalling in excitable cells and are the molecular targets for drugs and disease mutations, but the structural basis for their voltage-dependent activation, ion selectivity and drug block is unknown. Here we report the crystal structure of a voltage-gated Na(+) channel from Arcobacter butzleri (
Payandeh, Jian, Scheuer, Todd, Zheng, Ning, Catterall, William A.   +3 more
openaire   +2 more sources

Activity of Palythoa caribaeorum Venom on Voltage-Gated Ion Channels in Mammalian Superior Cervical Ganglion Neurons

Toxins, 2016
The Zoanthids are an order of cnidarians whose venoms and toxins have been poorly studied. Palythoa caribaeorum is a zoanthid commonly found around the Mexican coastline. In this study, we tested the activity of P.
Fernando Lazcano-Pérez, Héctor Castro, Isabel Arenas, David E. García, Ricardo González-Muñoz, Roberto Arreguín-Espinosa   +5 more
doaj   +1 more source

Cellular hyper-excitability caused by mutations that alter the activation process of voltage-gated sodium channels

Frontiers in Physiology, 2015
Voltage-gated sodium channels (Nav) are widely expressed as macro-molecular complexes in both excitable and non-excitable tissues. In excitable tissues, the upstroke of the action potential is the result of the passage of a large and rapid influx of ...
Mohamed-Yassine eAMAROUCH, Hugues eAbriel   +1 more
doaj   +1 more source

Regulation of pain neurotransmitters and chondrocytes metabolism mediated by voltage-gated ion channels: A narrative review

Heliyon, 2023
Osteoarthritis (OA) is one of the leading causes of chronic pain and dysfunction. It is essential to comprehend the nature of pain and cartilage degeneration and its influencing factors on OA treatment. Voltage-gated ion channels (VGICs) are essential in
Xinwei Wang, Xueping Li
doaj   +1 more source