Results 41 to 50 of about 57,423 (108)
Potential roles of voltage-gated ion channel disruption in Tuberous Sclerosis Complex
Frontiers in Molecular NeuroscienceTuberous Sclerosis Complex (TSC) is a lynchpin disorder, as it results in overactive mammalian target of rapamycin (mTOR) signaling, which has been implicated in a multitude of disease states.
Hailey X. Egido-Betancourt +2 more
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eLife, 2014 Entry and extrusion of cations are essential processes in living cells. In alkaliphilic prokaryotes, high external pH activates voltage-gated sodium channels (Nav), which allows Na+ to enter and be used as substrate for cation/proton antiporters ...
Paul G DeCaen +4 more
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Structural modeling of ion channels using AlphaFold2, RoseTTAFold2, and ESMFold
ChannelsIon channels play key roles in human physiology and are important targets in drug discovery. The atomic-scale structures of ion channels provide invaluable insights into a fundamental understanding of the molecular mechanisms of channel gating and ...
Phuong Tran Nguyen +5 more
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Propranolol blocks cardiac and neuronal voltage-gated sodium channels
Frontiers in Pharmacology, 2010 Propranolol is a widely-used, nonselective ß-adrenergic receptor antagonist with proven efficacy in treating cardiovascular disorders and in the prevention of migraine headaches.
Dao W Wang +7 more
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BiomedicinesVoltage-gated ion channels (VGICs) are traditionally associated with electrically excitable cells; however, increasing evidence indicates that they are also expressed in non-excitable cells, including vascular endothelial cells.
Francesco Moccia, Teresa Soda
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Ciguatoxins: Cyclic Polyether Modulators of Voltage-gated Iion Channel Function
Marine Drugs, 2006 Ciguatoxins are cyclic polyether toxins, derived from marine dinoflagellates, which are responsible for the symptoms of ciguatera poisoning. Ingestion of tropical and subtropical fin fish contaminated by ciguatoxins results in an illness characterised by
Richard J. Lewis, Graham M. Nicholson
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Voltage-gated sodium channels assemble and gate as dimers
Nature Communications, 2017 Voltage-gated sodium channels are expressed in excitable tissues and mutations have been linked to cardiac arrhythmias and channelopathies. Here the authors show that the sodium channel α-subunits interact to form a dimer and gate as dimer and that this ...
Jérôme Clatot +9 more
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Molecular and functional characterization of voltage-gated sodium channels in human sperm
Reproductive Biology and Endocrinology, 2009 Background We have investigated the expression of voltage-gated sodium channels in human spermatozoa and characterized their role in sperm motility. Methods Freshly ejaculated semen was collected from thirty normozoospermic human donors, with each donor ...
Cejudo-Román Antonio +5 more
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Nature CommunicationsThe poison dart toxin batrachotoxin is exceptional for its high potency and toxicity, and for its multifaceted modification of the function of voltage-gated sodium channels.
Lige Tonggu +8 more
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Phosphoinositide regulation of voltage-gated sodium channels. [PDF]
J Gen Physiol, 2023 Short B.
europepmc +1 more source