Results 141 to 150 of about 62,302 (192)
A binding site for phosphoinositides described by multiscale simulations explains their modulation of voltage-gated sodium channels. [PDF]
ElifeLin Y, Tao E, Champion JP, Corry B.
europepmc +1 more source
Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants. [PDF]
J Biol ChemRobinson SD +9 more
europepmc +1 more source
Machine learning study of the extended drug-target interaction network informed by pain related voltage-gated sodium channels. [PDF]
PainChen L +9 more
europepmc +1 more source
<i>N</i>-(4-Bromo-2,5-Dimethoxyphenethyl)-6-(4-Phenylbutoxy)Hexan-1-Amine (XOB): A Novel Phenylalkylamine Antagonist of Serotonin 2A Receptors and Voltage-Gated Sodium Channels. [PDF]
Mol PharmacolDenomme N +12 more
europepmc +1 more source
Ubiquitylation of Voltage-Gated Sodium Channels
, 2014 Ion channel proteins are regulated by different types of posttranslational modifications. The focus of this review is the regulation of voltage-gated sodium channels (Navs) upon their ubiquitylation. The amiloride-sensitive epithelial sodium channel (ENaC) was the first ion channel shown to be regulated upon ubiquitylation.
Laedermann, Cédric J +2 more
openaire +5 more sources
Effects of Benzothiazolamines on Voltage-Gated Sodium Channels
, 2017 Benzothiazole is a versatile fused heterocycle that aroused much interest in drug discovery as anticonvulsant, neuroprotective, analgesic, anti-inflammatory, antimicrobial, and anticancer. Two benzothiazolamines, riluzole and lubeluzole, are known blockers of voltage-gated sodium (Nav) channels.
Farinato, Alessandro +2 more
openaire +4 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Current Opinion in Pharmacology, 2015
Voltage-gated sodium channels play a key role in the transmission of sensory information about the status of organs in the periphery. Sensory fibers contain a heterogeneous yet specific distribution of voltage-gated sodium channel isoforms. Major efforts by industry and academic groups are underway to develop medicines that interrupt inappropriate ...
Kevin, Kwong, Michael J, Carr
openaire +3 more sources
Voltage-gated sodium channels play a key role in the transmission of sensory information about the status of organs in the periphery. Sensory fibers contain a heterogeneous yet specific distribution of voltage-gated sodium channel isoforms. Major efforts by industry and academic groups are underway to develop medicines that interrupt inappropriate ...
Kevin, Kwong, Michael J, Carr
openaire +3 more sources
Current Opinion in Pharmacology, 2001
Increased knowledge of the molecular diversity of sodium channel alpha- and beta-subunits, and their distribution of expression have been highlights of the past year. The development of subtype-specific channel blockers remains elusive, but the discovery of selective inhibitors such as mu-conotoxins promises useful antagonists in the near future.
J N, Wood, M, Baker
openaire +2 more sources
Increased knowledge of the molecular diversity of sodium channel alpha- and beta-subunits, and their distribution of expression have been highlights of the past year. The development of subtype-specific channel blockers remains elusive, but the discovery of selective inhibitors such as mu-conotoxins promises useful antagonists in the near future.
J N, Wood, M, Baker
openaire +2 more sources
Voltage-Gated Sodium Channels and Hyperalgesia
Annual Review of Pharmacology and Toxicology, 2004Physiological and pharmacological evidence both have demonstrated a critical role for voltage-gated sodium channels (VGSCs) in many types of chronic pain syndromes because these channels play a fundamental role in the excitability of neurons in the central and peripheral nervous systems. Alterations in function of these channels appear to be intimately
Josephine, Lai +3 more
openaire +2 more sources