Results 41 to 50 of about 107,111 (187)

Monte Carlo simulation for statistical mechanics model of ion channel cooperativity in cell membranes

, 2008
Voltage-gated ion channels are key molecules for the generation and propagation of electrical signals in excitable cell membranes. The voltage-dependent switching of these channels between conducting and nonconducting states is a major factor in ...
A. L. Hodgkin, A. V. Hill, B. Hille, D. J. Aidley, Ekrem Aydiner, P. Ghosh, Riza Erdem   +6 more
core   +1 more source

Voltage-gated sodium channels in taste bud cells

BMC Neuroscience, 2009
Background Taste bud cells transmit information regarding the contents of food from taste receptors embedded in apical microvilli to gustatory nerve fibers innervating basolateral membranes.
Williams Mark E, Kalabat Dalia, Laita Bianca, Echeverri Fernando, Lu Min, Gao Na, Hevezi Peter, Zlotnik Albert, Moyer Bryan D   +8 more
doaj   +1 more source

Ca2+ entry through NaV channels generates submillisecond axonal Ca2+ signaling

eLife, 2020
Calcium ions (Ca2+) are essential for many cellular signaling mechanisms and enter the cytosol mostly through voltage-gated calcium channels. Here, using high-speed Ca2+ imaging up to 20 kHz in the rat layer five pyramidal neuron axon we found that ...
Naomi AK Hanemaaijer, Marko A Popovic, Xante Wilders, Sara Grasman, Oriol Pavón Arocas, Maarten HP Kole   +5 more
doaj   +1 more source

Molecular basis of ion permeability in a voltage-gated sodium channel [PDF]

, 2016
Voltage‐gated sodium channels are essential for electrical signalling across cell membranes. They exhibit strong selectivities for sodium ions over other cations, enabling the finely tuned cascade of events associated with action potentials.
Altin Sula, Antonella Scaglione, BA Wallace, Bricogne G, Claire Bagnéris, Claire E Naylor, David E Clapham, Eswar N, Evans PR, Kabsch W, Paul G DeCaen, Zhang X   +11 more
core   +2 more sources

Behavior of ion channels controlled by electric potential difference and of Toll-type receptors in neuropathic pain pathophysiology

Revista Dor
BACKGROUND AND OBJECTIVES: Neuropathic pain is a severe and refractory medical condition, for which only partially effective treatments are currently available.
André Prato Schmidt, Sérgio Renato Guimarães Schmidt   +1 more
doaj   +1 more source

Molecular mechanisms of pyrethroid insecticide neurotoxicity: recent advances [PDF]

, 2018
Synthetic pyrethroid insecticides were introduced into widespread use for the control of insect pests and disease vectors more than three decades ago.
Soderlund, David
core  

The role of Nav1.9 channel in the development of neuropathic orofacial pain associated with trigeminal neuralgia [PDF]

, 2015
BACKGROUND: Trigeminal neuralgia is accompanied by severe mechanical, thermal and chemical hypersensitivity of the orofacial area innervated by neurons of trigeminal ganglion (TG).
Kopach, O, Luiz, AP, Santana-Varela, S, Wood, JN   +3 more
core   +1 more source

Inhibition by Pregnenolone Sulphate, a Metabolite of the Neurosteroid Pregnenolone, of Voltage-Gated Sodium Channels Expressed in Xenopus Oocytes

Journal of Pharmacological Sciences, 2012
Neurosteroids are known as allosteric modulators of the ligand-gated ion channel superfamily. Voltage-gated sodium channels (Nav) play an important role in mediating excitotoxic damages. Here we report the effects of neurosteroids on the function of Nav,
Takafumi Horishita, Susumu Ueno, Nobuyuki Yanagihara, Yuka Sudo, Yasuhito Uezono, Dan Okura, Takeyoshi Sata   +6 more
doaj   +1 more source

Insect-selective spider toxins targeting voltage-gated sodium channels [PDF]

, 2007
The voltage-gated sodium (Nav) channel is a target for a number of drugs, insecticides and neurotoxins. These bind to at least seven identified neurotoxin binding sites and either block conductance or modulate Nav channel gating.
Nicholson, GM
core   +1 more source

Effect of Crude Extract from the Sea Anemone Bunodeopsis globulifera on Voltage-Gated Ion Channels from Central and Peripheral Murine Nervous Systems

Pharmaceuticals
Sea anemones are an important source of bioactive compounds with potential pharmacological applications. Their toxins are produced and stored in organelles called nematocysts and act on specific targets, including voltage-gated ion channels. To date, sea
Aleida Jeannette Flores-Pérez, Santiago Loya-López, Arturo Ávalos-Fuentes, Aida Calderon-Rivera, Elisa Damo, Fernando Lazcano-Pérez, Rajesh Khanna, Benjamin Florán-Garduño, Judith Sánchez-Rodríguez   +8 more
doaj   +1 more source