Results 71 to 80 of about 2,241,154 (143)

Molecular and functional characterization of voltage-gated sodium channels in human sperm

Reproductive Biology and Endocrinology, 2009
Background We have investigated the expression of voltage-gated sodium channels in human spermatozoa and characterized their role in sperm motility. Methods Freshly ejaculated semen was collected from thirty normozoospermic human donors, with each donor ...
Cejudo-Román Antonio, Gallardo-Castro Manuel, Fernández-Sánchez Manuel, Ravina Cristina G, Pinto Francisco M, Candenas Luz   +5 more
doaj   +1 more source

The Biophysics of Voltage-Gated Skeletal Muscle Sodium Channels and Muscle Excitability

, 1997
Voltage-gated skeletal muscle sodium channels are large transmembrane proteins that are responsible for the initiation and propagation of skeletal muscle action potentials.
Featherstone, David E.
core   +1 more source

AI-assisted and physics-refined modeling of human voltage-gated sodium channels for selective target discovery [PDF]

Introduction: Voltage-gated sodium channels are membrane proteins that open and close in response to voltage changes to allow Na⁺ influx in excitable cells, enabling action potentials, muscle contraction, and electrical signaling.
Boazinha, João Pedro, Carneiro, João, Cerqueira, Nuno M. F. S. A., Sousa, Sérgio F.   +3 more
core   +1 more source

Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin

Nature Communications
The poison dart toxin batrachotoxin is exceptional for its high potency and toxicity, and for its multifaceted modification of the function of voltage-gated sodium channels.
Lige Tonggu, Goragot Wisedchaisri, Tamer M. Gamal El-Din, Michael J. Lenaeus, Matthew M. Logan, Tatsuya Toma, Justin Du Bois, Ning Zheng, William A. Catterall   +8 more
doaj   +1 more source

Behavioral/Systems/Cognitive

, 2008
nuates the amplitude of quantal synaptic voltages. These results demonstrate that Na amplify the synaptic voltage, enhancing the SNR and contrast sensitivity.
Narender K. Dhingra, Robert G. Smith, Michael A. Freed, Voltage-Gated Sodium Channels   +3 more
core  

Nedd4-2 (NEDD4L) controls intracellular Na(+) -mediated activity of voltage-gated sodium channels in primary cortical neurons

, 2014
Nedd4-2, a HECT (homologous with E6-associated protein C-terminus)-type ubiquitin protein ligase, has been implicated in regulating several ion channels, including Navs (voltage-gated sodium channels).
Ekberg, J., Poronnik, Philp, Rychkov, G., Poronnik, P., Boase, Natasha A, Kumar, Sharad, Rychkov, Grigori, Ekberg, Jenny A, Manning, Jantina, Kumar, S., Boase, N., Manning, J.   +11 more
core   +1 more source

Compounds used in this Study, the LD₅₀ Values for Bees and Their Interactions with Voltage-Gated Sodium Channels.

, 2015
Compounds used in this Study, the LD50 Values for Bees and Their Interactions with Voltage-Gated Sodium Channels.
Sally M. Williamson (371694), Geraldine A. Wright (179571), Samantha Softley (784209), Philip C. Stevenson (300181), Caitlin J. Oliver (784208)   +4 more
core   +1 more source

Voltage-Gated Sodium Channels Modulation by Bothutous Schach Scorpion Venom

, 2020
Buthotus schach is one of the dangers scorpions in Iran that belong to the Buthidae family. Toxins are existing in venom scorpion, modulate the ion channels by blocking or opening the pore of the channel or by altering the voltage gating and useful as ...
Hossein Vatanpour, Hossein Zolfagharian, Nima Naderi, Hamid Gholami Pourbadie D, Akram Aboutorabi   +4 more
core  

Phosphoinositide regulation of voltage-gated sodium channels. [PDF]

J Gen Physiol, 2023
Short B.
europepmc   +1 more source

Hybrid computational modelling of human voltage-gated sodium channels for isoform-specific therapeutic design [PDF]

Introduction: Voltage-gated sodium channels are membrane proteins that open and close in response to voltage changes to allow Na+ influx in excitable cells, enabling action potentials, muscle contraction, and electrical signaling.
Boazinha, João Pedro, Carneiro, João, Cerqueira, Nuno M. F. S. A., Sousa, Sérgio F.   +3 more
core