Results 1 to 10 of about 42,109 (135)

De Novo Expressed Vpr Stimulates HIV-1 Replication in T Cells [PDF]

Viruses
Vpr, a virion-associated accessory virulence factor of HIV-1, promotes virus replication in both T cells and macrophages. Although Vpr’s early activity—antagonism of preintegration silencing and host restriction factors—has been documented, the relative ...
Blessing Enya, Jacek Skowronski
doaj   +2 more sources

HIV-1 Vpr suppresses expression of the thiazide-sensitive sodium chloride co-transporter in the distal convoluted tubule.

PLoS ONE, 2022
HIV-associated nephropathy (HIVAN) impairs functions of both glomeruli and tubules. Attention has been previously focused on the HIVAN glomerulopathy. Tubular injury has drawn increased attention because sodium wasting is common in hospitalized HIV/AIDS ...
Shashi Shrivastav, Hewang Lee, Koji Okamoto, Huiyan Lu, Teruhiko Yoshida, Khun Zaw Latt, Hidefumi Wakashin, James L T Dalgleish, Erik H Koritzinsky, Peng Xu, Laureano D Asico, Joon-Yong Chung, Stephen Hewitt, John J Gildea, Robin A Felder, Pedro A Jose, Avi Z Rosenberg, Mark A Knepper, Tomoshige Kino, Jeffrey B Kopp   +19 more
doaj   +2 more sources

Nuclear exportin receptor CAS regulates the NPI-1-mediated nuclear import of HIV-1 Vpr. [PDF]

PLoS ONE, 2011
Vpr, an accessory protein of human immunodeficiency virus type 1, is a multifunctional protein that plays an important role in viral replication. We have previously shown that the region between residues 17 and 74 of Vpr (Vpr(N17C74)) contained a bona ...
Eri Takeda, Tomoyuki Murakami, Go Matsuda, Hironobu Murakami, Tamotsu Zako, Mizuo Maeda, Yoko Aida   +6 more
doaj   +1 more source

Protein Arginine N-methyltransferases 5 and 7 Promote HIV-1 Production

Viruses, 2020
Current therapies for human immunodeficiency virus type 1 (HIV-1) do not completely eliminate viral reservoirs in cells, such as macrophages. The HIV-1 accessory protein viral protein R (Vpr) promotes virus production in macrophages, and the maintenance ...
Hironobu Murakami, Takehiro Suzuki, Kiyoto Tsuchiya, Hiroyuki Gatanaga, Manabu Taura, Eriko Kudo, Seiji Okada, Masami Takei, Kazumichi Kuroda, Tatsuo Yamamoto, Kyoji Hagiwara, Naoshi Dohmae, Yoko Aida   +12 more
doaj   +1 more source

Distinct MCM10 Proteasomal Degradation Profiles by Primate Lentiviruses Vpr Proteins

Viruses, 2020
Viral protein R (Vpr) is an accessory protein found in various primate lentiviruses, including human immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2) as well as simian immunodeficiency viruses (SIVs).
Hao Chang, Lowela Siarot, Ryosuke Matsuura, Chieh-Wen Lo, Hirotaka Sato, Hiroyuki Otsuki, Yoko Aida   +6 more
doaj   +1 more source

The HIV1 protein Vpr acts to enhance constitutive DCAF1-dependent UNG2 turnover. [PDF]

PLoS ONE, 2012
The HIV1 protein Vpr assembles with and acts through an ubiquitin ligase complex that includes DDB1 and cullin 4 (CRL4) to cause G2 cell cycle arrest and to promote degradation of both uracil DNA glycosylase 2 (UNG2) and single-strand selective mono ...
Xiaoyun Wen, Laurieann Casey Klockow, Michael Nekorchuk, Hamayun J Sharifi, Carlos M C de Noronha   +4 more
doaj   +1 more source

HIV-1 Vpr Abrogates the Effect of TSG101 Overexpression to Support Virus Release. [PDF]

PLoS ONE, 2016
HIV-1 budding requires interaction between Gag and cellular TSG101 to initiate viral particle assembly and release via the endosomal sorting complexes required for transport (ESCRT) pathway.
Nopporn Chutiwitoonchai, Lowela Siarot, Eri Takeda, Tatsuo Shioda, Motoki Ueda, Yoko Aida   +5 more
doaj   +1 more source

Visualizing Vpr-induced G2 arrest and apoptosis. [PDF]

PLoS ONE, 2014
Vpr is an accessory protein of human immunodeficiency virus type 1 (HIV-1) with multiple functions. The induction of G2 arrest by Vpr plays a particularly important role in efficient viral replication because the transcriptional activity of the HIV-1 ...
Tomoyuki Murakami, Yoko Aida
doaj   +1 more source

HIV-1 Vpr activates host CRL4-DCAF1 E3 ligase to degrade histone deacetylase SIRT7

Virology Journal, 2021
Background Vpr is a virion-associated protein that is encoded by lentiviruses and serves to counteract intrinsic immunity factors that restrict infection.
Xiaohong Zhou, Christina Monnie, Maria DeLucia, Jinwoo Ahn   +3 more
doaj   +1 more source

Parallel FPGA Routers With Lagrange Relaxation

IEEE Access, 2023
Routing of the nets in Field Programmable Gate Array (FPGA) design flow is one of the most time consuming steps. Although Versatile Place and Route (VPR), which is a commonly used algorithm for this purpose, routes effectively, it is slow in execution ...
Rohit Agrawal, Kapil Ahuja, Dhaarna Maheshwari, Mohd Ubaid Shaikh, Mohamed Bouaziz, Akash Kumar   +5 more
doaj   +1 more source