Direct Vpr-Vpr Interaction in Cells monitored by two Photon Fluorescence Correlation Spectroscopy and Fluorescence Lifetime Imaging [PDF]
Retrovirology, 2008 Background The human immunodeficiency virus type 1 (HIV-1) encodes several regulatory proteins, notably Vpr which influences the survival of the infected cells by causing a G2/M arrest and apoptosis.
Mély Yves +10 more
doaj +3 more sources
Vpr Is a VIP: HIV Vpr and Infected Macrophages Promote Viral Pathogenesis [PDF]
Viruses, 2020 HIV infects several cell types in the body, including CD4+ T cells and macrophages. Here we review the role of macrophages in HIV infection and describe complex interactions between viral proteins and host defenses in these cells. Macrophages exist in many forms throughout the body, where they play numerous roles in healthy and diseased states.
Jay Lubow, Kathleen L. Collins
openaire +3 more sources
Virion encapsidated HIV-1 Vpr induces NFAT to prime non-activated T cells for productive infection [PDF]
Open Biology, 2016 The majority of T cells encountered by HIV-1 are non-activated and do not readily allow productive infection. HIV-1 Vpr is highly abundant in progeny virions, and induces signalling and HIV-1 LTR transcription.
Kristin Höhne +9 more
doaj +1 more source
Evolutionary Toggling of Vpx/Vpr Specificity Results in Divergent Recognition of the Restriction Factor SAMHD1 [PDF]
, 2013 SAMHD1 is a host restriction factor that blocks the ability of lentiviruses such as HIV-1 to undergo reverse transcription in myeloid cells and resting T-cells. This restriction is alleviated by expression of the lentiviral accessory proteins Vpx and Vpr
A Bergamaschi +47 more
core +3 more sources
The role of visual appearance in Punch’s early-Victorian satires on religion [PDF]
, 2014 Satires on various aspects of contemporary religion can frequently be found in the early Victorian editions of Punch. The more strident forms of Protestant evangelicalism, in the earlier 1840s, and Roman Catholic revivalism, around 1850, came in for ...
Janes, Dominic
core +1 more source
Characterization of a novel type of HIV-1 particle assembly inhibitor using a quantitative Luciferase-Vpr packaging-based assay [PDF]
, 2011 The HIV-1 auxiliary protein Vpr and Vpr-fusion proteins can be copackaged with Gag precursor (Pr55Gag) into virions or membrane-enveloped virus-like particles (VLP).
Elisabeth Errazuriz +9 more
core +5 more sources
Yeast perspectives on HIV-1 VPR [PDF]
Frontiers in Bioscience, 2000 Increasing evidence suggests that HIV-1 viral protein R (Vpr) plays an important role in viral pathogenesis, as its functions are being linked to viral activation, suppression of human immune functions and depletion of human CD4 lymphocytes, which are the major clinical manifestation of AIDS.
Y, Zhao, R T, Elder
openaire +2 more sources
Retrovirology, 2007 Background HIV-1 Vpr is a dynamic protein that primarily localizes in the nucleus, but a significant fraction is concentrated at the nuclear envelope (NE), supporting an interaction between Vpr and components of the nuclear pore complex, including the ...
Bouaziz Serge +8 more
doaj +1 more source
New Insights Into the Virus-to-Prokaryote Ratio (VPR) in Marine Sediments
Frontiers in Microbiology, 2020 The virus-to-prokaryote ratio (VPR), which reflects the numerical dominance of viruses over their hosts, has been proposed as a proxy for assessing the relationship between viruses and prokaryotes.
Miao Wei +5 more
doaj +1 more source
PP2A1 binding, cell transducing and apoptotic properties of Vpr(77-92): a new functional domain of HIV-1 Vpr proteins. [PDF]
PLoS ONE, 2010 BACKGROUND: The hallmark of HIV-1 pathogenesis is the progressive CD4(+) T cell depletion and high propensity of CD4(+) T cells to apoptosis. HIV-1 viral protein R (Vpr) is a major pro-apoptotic gene product. A first Vpr-mediated apoptotic mechanism that
Angélique N Godet +6 more
doaj +1 more source