Results 21 to 30 of about 42,178 (200)

HIV-1 Accessory Proteins: VpR [PDF]

, 2014
HIV-1 viral protein R (VpR) is a multifunctional protein that plays specific roles at multiple stages of the HIV-1 viral life cycle and affects anti-HIV functions of the immune cells. VpR is required for efficient viral replication in nondividing cells such as macrophages, and it promotes, to some extent, viral replication in the proliferating target ...
Richard Y, Zhao, Michael I, Bukrinsky
openaire   +2 more sources

Mind the (synthesis) gap: examining where academic FPGA tools lag behind industry [PDF]

, 2015
Firstly, we present VTR-to-Bitstream v2.0, the latest version of our open-source toolchain that takes Verilog input and produces a packed, placed— and now routed—solution that can be programmed onto the Xilinx commercial FPGA architecture.
Hung, E
core   +1 more source

Vipirinin, a Coumarin-based HIV-1 Vpr Inhibitor, Interacts with a Hydrophobic Region of VPR [PDF]

Journal of Biological Chemistry, 2011
La proteína viral R (Vpr) del virus de la inmunodeficiencia humana 1 (VIH-1) es una proteína accesoria que se ha demostrado que tiene múltiples funciones en la patogénesis del VIH-1. Mediante el cribado de bibliotecas químicas en el Depósito de Productos Naturales de RIKEN, identificamos un compuesto a base de 3-fenil cumarina que inhibía la actividad ...
Eugene Boon Beng Ong, Nobumoto Watanabe, Akiko Saito, Yushi Futamura, Khaled H. Abd El Galil, Atsushi Koito, Nazalan Najimudin, Hiroyuki Osada   +7 more
openaire   +2 more sources

Inhibition of NF‐κB activity by HIV‐1 Vpr is dependent on Vpr binding protein [PDF]

Journal of Cellular Physiology, 2012
AbstractNumerous studies have reported that Vpr alters NF‐κB signaling in various cell types, however, the findings have been largely conflicting with reports of both stimulatory and inhibitory effects of Vpr. Our aim was to investigate the role of Vpr signaling in myeloid cells using an adenovirus based expression and indicator system.
Michael, Kogan, Satish, Deshmane, Bassel E, Sawaya, Edward J, Gracely, Kamel, Khalili, Jay, Rappaport   +5 more
openaire   +2 more sources

Bimodal Expression Patterns, and Not Viral Burst Sizes, Predict the Effects of Vpr on HIV-1 Proviral Populations in Jurkat Cells

mBio, 2022
Integration site landscapes, clonal dynamics, and latency reversal with or without vpr were compared in HIV-1-infected Jurkat cell populations, and the properties of individual clones were defined.
Edmond Atindaana, Abena Kissi-Twum, Sarah Emery, Cleo Burnett, Jake Pitcher, Myra Visser, Jeffrey M. Kidd, Alice Telesnitsky   +7 more
doaj   +1 more source

HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137

eLife, 2020
The HIV-1 Vpr accessory protein induces ubiquitin/proteasome-dependent degradation of many cellular proteins by recruiting them to a cullin4A-DDB1-DCAF1 complex.
Fengwen Zhang, Paul D Bieniasz
doaj   +1 more source

HIV-1 Vpr induces the degradation of ZIP and sZIP, adaptors of the NuRD chromatin remodeling complex, by hijacking DCAF1/VprBP. [PDF]

PLoS ONE, 2013
The Vpr protein from type 1 and type 2 Human Immunodeficiency Viruses (HIV-1 and HIV-2) is thought to inactivate several host proteins through the hijacking of the DCAF1 adaptor of the Cul4A ubiquitin ligase.
Claire Maudet, Adèle Sourisce, Loïc Dragin, Hichem Lahouassa, Jean-Christophe Rain, Serge Bouaziz, Bertha Cécilia Ramirez, Florence Margottin-Goguet   +7 more
doaj   +1 more source

Expanding the CRISPR toolbox in Culicine mosquitoes: in vitro validation of Pol III promoters [PDF]

, 2020
CRISPR–Cas9-based “gene drive” technologies have been proposed as a novel and effective means of controlling human diseases vectored by mosquitoes. However, more complex designs than those demonstrated to date—and an expanded molecular toolbox with which
Alphey, Luke, Anderson, Michelle, Harvey-Samuel, Tim, Leftwich, Philip, Norman, Victoria, Purcell, Jessica, Verkuijl, Sebald   +6 more
core   +1 more source

Evidence Theory and VPRS model

Electronic Notes in Theoretical Computer Science, 2003
AbstractThe Rough Set Theory (RST) was proposed by Pawlak [4] as a new mathematical approach to deal with uncertain knowledge in expert systems. In 1991 Ziarko [11] proposed the Variable Precision Rough Set Model (VPRSM) as a certain extension of the rough set theory.
Marszał-Paszek, Barbara, Paszek, Piotr
openaire   +3 more sources

Characterization of the molecular determinants of primary HIV-1 Vpr proteins: impact of the Q65R and R77Q substitutions on Vpr functions. [PDF]

PLoS ONE, 2009
Although HIV-1 Vpr displays several functions in vitro, limited information exists concerning their relevance during infection. Here, we characterized Vpr variants isolated from a rapid and a long-term non-progressor (LTNP).
Guillaume Jacquot, Erwann Le Rouzic, Priscilla Maidou-Peindara, Marion Maizy, Jean-Jacques Lefrère, Vincent Daneluzzi, Carlos M R Monteiro-Filho, Duanping Hong, Vicente Planelles, Laurence Morand-Joubert, Serge Benichou   +10 more
doaj   +1 more source