HIV Vpr controls CNS metabolism [PDF]
Cell Cycle, 2016 The vpr gene is conserved among human and simian immunodeficiency viruses and encodes the regulatory viral protein R (Vpr), a small basic protein (14 kDa) of 96 amino acids.1 The significance of Vp...
Stacey Boyd +2 more
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Modeling and Detecting False Data Injection Attacks against Railway Traction Power Systems [PDF]
, 2017 Modern urban railways extensively use computerized sensing and control technologies to achieve safe, reliable, and well-timed operations. However, the use of these technologies may provide a convenient leverage to cyber-attackers who have bypassed the ...
Lakshminarayana, Subhash +3 more
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Release of Soluble Ligands for the Activating NKG2D Receptor: One More Immune Evasion Strategy Evolved by HIV-1? [PDF]
, 2016 ncreasing lines of evidence indicate that NKG2D, an activating receptor of natural killer (NK) and CD8(+) T cells, plays an important role in immune responses against HIV-1. Through its ability to recognize a diverse array of ligands (NKG2DLs) induced by
Cerboni, Cristina +3 more
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Structural alteration of DNA induced by viral protein R of HIV-1 triggers the DNA damage response
Retrovirology, 2018 Background Viral protein R (Vpr) is an accessory protein of HIV-1, which is potentially involved in the infection of macrophages and the induction of the ataxia-telangiectasia and Rad3-related protein (ATR)-mediated DNA damage response (DDR).
Kenta Iijima +2 more
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Defining the interactions and role of DCAF1/VPRBP in the DDB1-cullin4A E3 ubiquitin ligase complex engaged by HIV-1 Vpr to induce a G2 cell cycle arrest. [PDF]
PLoS ONE, 2014 HIV viral protein R (Vpr) induces a cell cycle arrest at the G2/M phase by activating the ATR DNA damage/replication stress signalling pathway through engagement of the DDB1-CUL4A-DCAF1 E3 ubiquitin ligase via a direct binding to the substrate ...
Francine C A Gérard +6 more
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Huntingtin-Interacting Protein 1 Promotes Vpr-Induced G2 Arrest and HIV-1 Infection in Macrophages
Viruses, 2021 Human immunodeficiency virus type 1 (HIV-1) modulates the host cell cycle. The HIV-1 accessory protein Vpr arrests the cell cycle at the G2 phase in dividing cells, and the ability of Vpr to induce G2 arrest is well conserved among primate lentiviruses ...
Tomoyuki Murakami +4 more
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HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system
Virology Journal, 2007 HIV-1 Vpr is a viral accessory protein that activates ATR through the induction of DNA replication stress. ATR activation results in cell cycle arrest in G2 and induction of apoptosis.
Argañaraz Enrique R +5 more
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Differential effects of Vpr on single-cycle and spreading HIV-1 infections in CD4+ T-cells and dendritic cells. [PDF]
PLoS ONE, 2012 The Vpr protein of human immunodeficiency virus type 1 (HIV-1) contributes to viral replication in non-dividing cells, specifically those of the myeloid lineage.
Suresh de Silva +2 more
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Vpr loosens chromatid ties [PDF]
Journal of Cell Biology, 2011 ![Figure][1] Compared to cells lacking Vpr (left), the cohesin Rad21 (red) is prematurely lost from centromeres (arrowheads) in the presence of Vpr (right). An HIV-1 protein promotes chromosome missegregation by epigenetically modifying centromeric chromatin, [Shimura et al.][2] report.
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HIV-1 Vpr Oligomerization but Not That of Gag Directs the Interaction between Vpr and Gag [PDF]
Journal of Virology, 2010 ABSTRACT During HIV-1 assembly, the viral protein R (Vpr) is incorporated into newly made viral particles via an interaction with the C-terminal domain of the Gag polyprotein precursor Pr55 Gag .
Joëlle V, Fritz +7 more
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