Results 51 to 60 of about 42,178 (200)

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

HIV-1 replication through hHR23A-mediated interaction of Vpr with 26S proteasome.

PLoS ONE, 2010
HIV-1 Vpr is a virion-associated protein. Its activities link to viral pathogenesis and disease progression of HIV-infected patients. In vitro, Vpr moderately activates HIV-1 replication in proliferating T cells, but it is required for efficient viral ...
Ge Li, Robert T Elder, Larisa Dubrovsky, Dong Liang, Tatiana Pushkarsky, Karen Chiu, Tao Fan, Josephine Sire, Michael Bukrinsky, Richard Y Zhao   +9 more
doaj   +1 more source

Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication [PDF]

Open Biology, 2017
Viruses interact with multiple host cell factors. Some of these are required to promote viral propagation, others have roles in inhibiting infection. Here, we delineate the function of the cellular factor PHF13 (or SPOC1), a putative HIV-1 restriction ...
Stephan Hofmann, Sandra Dehn, Ramona Businger, Sebastian Bolduan, Martha Schneider, Zeger Debyser, Ruth Brack-Werner, Michael Schindler   +7 more
doaj   +1 more source

Interventional therapies for chronic heart failure: An overview of recent developments

ESC Heart Failure, Volume 12, Issue 2, Page 1081-1094, April 2025.
Abstract Heart failure (HF), the final manifestation of most cardiovascular diseases, has become a major global health concern, affecting millions of individuals. Despite basic drug treatments, patients present with high morbidity and mortality rates. However, recent advancements in interventional therapy have shown promising results in improving the ...
Bingchen Guo, Si Shi, Yutong Guo, Jie Xiong, Bo Wang, Zengxiang Dong, Dianyu Gao, Yingfeng Tu   +7 more
wiley   +1 more source

Anti-cancer effect of HIV-1 viral protein R on doxorubicin resistant neuroblastoma.

PLoS ONE, 2010
Several unique biological features of HIV-1 Vpr make it a potentially powerful agent for anti-cancer therapy. First, Vpr inhibits cell proliferation by induction of cell cycle G2 arrest.
Richard Y Zhao, Dong Liang, Ge Li, Christopher W Larrimore, Bernard L Mirkin   +4 more
doaj   +1 more source

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Vpr makes holes

The Journal of Cell Biology, 2001
![][1] Nuclear holes allow Wee1 to escape (top, left to right) and Cdc25C to enter (bottom) the nucleus. Greene/AAAS The Vpr protein from HIV-1 makes holes in the nucleus, according to Warner Greene (Gladstone Institute of Virology and Immunology, University of California ...
openaire   +2 more sources

HIV‐1 auxiliary regulatory protein Vpr promotes ubiquitination and turnover of Vpr mutants containing the L64P mutation [PDF]

FEBS Letters, 2004
The auxiliary regulatory protein Vpr of HIV‐1 possesses several biological activities which are believed to facilitate HIV‐1 replication and pathogenesis. In this report, experimental evidence suggests a novel biological activity of Vpr: facilitation of the turnover of Vpr mutants bearing the L64P mutation.
Zhao, Ling-Jun, Jian, Heng, Zhu, Henghu
openaire   +2 more sources

Transcriptional Regulation of Tumor Necrosis Factor-alpha by Human Immunodeficiency Virus-1 Vpr [PDF]

, 2008
HIV-1 Vpr is known to regulate both viral and host cellular promoters resulting in transcriptional regulation of various cellular factors in host immune cells, such as T cells, macrophages and dendritic cells. It has been shown that Vpr has a role in the
O'Leary, Shaylee Marie
core  

HBST: A Hamming Distance embedding Binary Search Tree for Visual Place Recognition [PDF]

, 2018
Reliable and efficient Visual Place Recognition is a major building block of modern SLAM systems. Leveraging on our prior work, in this paper we present a Hamming Distance embedding Binary Search Tree (HBST) approach for binary Descriptor Matching and ...
Grisetti, Giorgio, Schlegel, Dominik
core   +2 more sources