Results 1 to 10 of about 43,668 (144)

Limited G-dependent residual infectivity of G gene–deleted vesicular stomatitis virus [PDF]

Virus Research
Vesicular stomatitis virus (VSV) -ΔG vector particles are widely applied in vaccine development, gene delivery, and immunotherapy studies due to their high transduction efficiency and replication-defective design.
Kangyixin Sun, Li Li, Jia Yang, Fuqiang Xu, Fan Jia   +4 more
doaj   +2 more sources

Tumor-directed evolution of VSVΔ51M produces novel viruses with enhanced antitumor efficacy [PDF]

Frontiers in Molecular Biosciences
Oncolytic virotherapy has gained enormous attention and is undergoing extensive research, specifically, the Vesicular Stomatitis Virus (VSV). VSV has been shown to provide a potential tool on which many modifications can be introduced to improve its ...
Omar A. Albaradie, Omar A. Albaradie, Abdulaziz Molham Moglan, Abdulaziz Molham Moglan, Yahya Marwan Samman, Yahya Marwan Samman, Fares Fayez Alsayegh, Fares Fayez Alsayegh, Hussam Mohsen Alharbi, Hussam Mohsen Alharbi, Nada Almarghalani, Nada Almarghalani, Khulood Alotaibi, Khulood Alotaibi, Mohammed M. Jalal, Malik A. Altayar, Nizar H. Saeedi, Hanan A. Niaz, Samer Zakri, Samer Zakri, Adnan Almuzaini, Feras Kaboha, Saleh Y. Alabbas, Yasmeen A. Albalawi, Abeer Alsofyani, Abeer Alsofyani, Adrian Pelin, Adrian Pelin, May Abdulaiz Alsayb, May Abdulaiz Alsayb, Shymaa Damfo, Shymaa Damfo, Ahmad Bakur Mahmoud, Ahmad Bakur Mahmoud, Almohanad A. Alkayyal, Almohanad A. Alkayyal   +35 more
doaj   +2 more sources

Leveraging Synthetic Virology for the Rapid Engineering of Vesicular Stomatitis Virus (VSV)

Viruses
Vesicular stomatitis virus (VSV) is a prototype RNA virus that has been instrumental in advancing our understanding of viral molecular biology and has applications in vaccine development, cancer therapy, antiviral screening, and more.
Bruce F Smith, Rupsa Basu, Chad Moles
exaly   +3 more sources

Transcriptional signatures of rapid protection from Sudan virus infection by a single dose of a vesicular stomatitis virus-based vaccine. [PDF]

PLoS Pathogens
Sudan virus (SUDV) has caused multiple outbreaks of human disease with case fatality rates ranging from 41 to 100%. We have previously shown that a single vaccination with a recombinant vesicular stomatitis virus-based vaccine expressing the SUDV-Gulu ...
Brianna M Doratt, Sheridan B Wagner, Delphine C Malherbe, Geoffrey Smith, Andrea Marzi, Ilhem Messaoudi   +5 more
doaj   +2 more sources

Sox4 represses host innate immunity to facilitate pathogen infection by hijacking the TLR signaling networks

Virulence, 2021
Toll-like receptors (TLRs) are essential for the protection of the host from pathogen infections by initiating the integration of contextual cues to regulate inflammation and immunity.
Jian Shang, Yuan Zheng, Jiayin Mo, Wenbiao Wang, Zhen Luo, Yongkui Li, Xulin Chen, Qiwei Zhang, Kailang Wu, Weiyong Liu, Jianguo Wu   +10 more
doaj   +1 more source

Differential infection of murine and human dendritic cell subsets by oncolytic vesicular stomatitis virus variants

OncoImmunology, 2021
Oncolytic viruses (OVs) can eradicate tumor cells and elicit antitumor immunity. VSV-GP, a chimeric vesicular stomatitis virus (VSV) with the glycoprotein (GP) of the lymphocytic choriomeningitis virus, is a promising new OV candidate.
Lisa Pipperger, Lydia Riepler, Janine Kimpel, Anita Siller, Patrizia Stoitzner, Zoltán Bánki, Dorothee von Laer   +6 more
doaj   +1 more source

Comparative analysis of oncolytic potential of vesicular stomatitis virus serotypes Indiana and New Jersey in cancer cell lines

Сеченовский вестник, 2023
Aim. Compare the lytic efficiency and the kinetics of accumulation of vesicular stomatitis virus serotypes Indiana (VSV-IND) and New Jersey (VSV-NJ) on cell lines of mouse melanoma B16F10, human hepatocellular carcinoma HepG2 and human mammary ...
A. S. Isaeva, N. O. Porozova, E. Idota, S. I. Volodina, A. N. Lukashev, A. S. Malogolovkin   +5 more
doaj   +1 more source

In Vitro and In Vivo Attenuation of Vesicular Stomatitis Virus (VSV) by Phosphoprotein Deletion. [PDF]

PLoS ONE, 2016
Vesicular stomatitis virus (VSV) is highly immunogenic and able to stimulate both innate and adaptive immune responses. However, its ability to induce adverse effects has held back the use of VSV as a potential vaccine vector.
Phonphimon Wongthida, Juggragarn Jengarn, Jaraspim Narkpuk, Pongpisid Koonyosying, Kanjana Srisutthisamphan, Asawin Wanitchang, Pornsawan Leaungwutiwong, Samaporn Teeravechyan, Anan Jongkaewwattana   +8 more
doaj   +1 more source

High dose of vesicular stomatitis virus-vectored Ebola virus vaccine causes vesicular disease in swine without horizontal transmission

Emerging Microbes and Infections, 2021
The recent impact of Ebola virus disease (EVD) on public health in Africa clearly demonstrates the need for a safe and efficacious vaccine to control outbreaks and mitigate its threat to global health.
Igor Morozov, Thomas P. Monath, David A. Meekins, Jessie D. Trujillo, Sun-Young Sunwoo, Kinga Urbaniak, In Joong Kim, Sanjeev K. Narayanan, Sabarish V. Indran, Wenjun Ma, William C. Wilson, Cassandra O'Connor, Sheri Dubey, Sean P. Troth, Beth-Ann Coller, Richard Nichols, Brian K. Martin, Heinz Feldmann, Juergen A. Richt   +18 more
doaj   +1 more source

TRIM41-Mediated Ubiquitination of Nucleoprotein Limits Vesicular Stomatitis Virus Infection

Viruses, 2020
Vesicular stomatitis virus (VSV) is a zoonotic, negative-stranded RNA virus of the family Rhabdoviridae. The nucleoprotein (N) of VSV protects the viral genomic RNA and plays an essential role in viral transcription and replication, which makes the ...
Girish Patil, Lingling Xu, Yakun Wu, Kun Song, Wenzhuo Hao, Fang Hua, Lingyan Wang, Shitao Li   +7 more
doaj   +1 more source