Results 1 to 10 of about 48,453 (241)

TLR7 Controls VSV Replication in CD169+ SCS Macrophages and Associated Viral Neuroinvasion [PDF]

Frontiers in Immunology, 2019
Vesicular stomatitis virus (VSV) is an insect-transmitted rhabdovirus that is neurovirulent in mice. Upon peripheral VSV infection, CD169+ subcapsular sinus (SCS) macrophages capture VSV in the lymph, support viral replication, and prevent CNS ...
Franz Puttur, Vikas Duhan, Vishal Khairnar   +2 more
exaly   +4 more sources

Transcriptional signatures of rapid protection from Sudan virus infection by a single dose of a vesicular stomatitis virus-based vaccine. [PDF]

PLoS Pathogens
Sudan virus (SUDV) has caused multiple outbreaks of human disease with case fatality rates ranging from 41 to 100%. We have previously shown that a single vaccination with a recombinant vesicular stomatitis virus-based vaccine expressing the SUDV-Gulu ...
Brianna M Doratt, Sheridan B Wagner, Delphine C Malherbe, Geoffrey Smith, Andrea Marzi, Ilhem Messaoudi   +5 more
doaj   +2 more sources

Tumor-directed evolution of VSVΔ51M produces novel viruses with enhanced antitumor efficacy [PDF]

Frontiers in Molecular Biosciences
Oncolytic virotherapy has gained enormous attention and is undergoing extensive research, specifically, the Vesicular Stomatitis Virus (VSV). VSV has been shown to provide a potential tool on which many modifications can be introduced to improve its ...
Omar A. Albaradie, Omar A. Albaradie, Abdulaziz Molham Moglan, Abdulaziz Molham Moglan, Yahya Marwan Samman, Yahya Marwan Samman, Fares Fayez Alsayegh, Fares Fayez Alsayegh, Hussam Mohsen Alharbi, Hussam Mohsen Alharbi, Nada Almarghalani, Nada Almarghalani, Khulood Alotaibi, Khulood Alotaibi, Mohammed M. Jalal, Malik A. Altayar, Nizar H. Saeedi, Hanan A. Niaz, Samer Zakri, Samer Zakri, Adnan Almuzaini, Feras Kaboha, Saleh Y. Alabbas, Yasmeen A. Albalawi, Abeer Alsofyani, Abeer Alsofyani, Adrian Pelin, Adrian Pelin, May Abdulaiz Alsayb, May Abdulaiz Alsayb, Shymaa Damfo, Shymaa Damfo, Ahmad Bakur Mahmoud, Ahmad Bakur Mahmoud, Almohanad A. Alkayyal, Almohanad A. Alkayyal   +35 more
doaj   +2 more sources

Coronavirus M Protein Hijacks Toll-Interacting Protein (TOLLIP) to Suppress NF-κB Signaling and Promote Immune Evasion. [PDF]

MedComm (2020)
Under physiological conditions, pathogenic stimuli activate TLR/IL1‐R signaling, triggering TOLLIP dissociation from IRAK1 and subsequent IRAK1 phosphorylation, TRAF6 ubiquitination, and NF‐κB activation. During SARS‐CoV‐2 infection, viral M protein binds TOLLIP and stabilizes the TOLLIP–IRAK1 complex, thereby suppressing NF‐κB signaling, impairing ...
Zhang Y, Kang L, Zhong Y, Shao S, Xue S, Liu C, Zheng X, Lin JW, Chen Y, Luo F, Wan H.   +10 more
europepmc   +2 more sources

ATG7 Limits Basal Antiviral Gene Expression and Moderately Promotes VSV Replication in Mammalian Non-Immune Cells [PDF]

Pathogens
The autophagy regulator ATG7 helps maintain cellular homeostasis and has been suggested to modulate aspects of antiviral immune responses. In Drosophila, ATG7-dependent autophagy contributes to host resistance to vesicular stomatitis virus (VSV), a ...
Xiaohan Tong, Ruixue Wang, Yaxin Liu, Malia B. Potts, Shondra M. Pruett-Miller, Michael A. Whitt, Weikuan Gu, Kui Li   +7 more
doaj   +2 more sources

Ginsenoside Rh1 Suppresses Vesicular Stomatitis Virus Replication by Inhibiting Autophagy to Promote Immune Responses [PDF]

Microorganisms
Vesicular stomatitis virus (VSV), a member of the Vesiculovirus genus within the Rhabdoviridae family, is a widespread pathogen affecting all hoofed livestock species, leading to reduced animal growth and productivity.
Hongmei Chen, Qinglu Zhao, Dingcheng Wei, Zhanying Hu, Xueliang Zhu, Rui Zhang   +5 more
doaj   +2 more sources

Leveraging Synthetic Virology for the Rapid Engineering of Vesicular Stomatitis Virus (VSV)

Viruses
Vesicular stomatitis virus (VSV) is a prototype RNA virus that has been instrumental in advancing our understanding of viral molecular biology and has applications in vaccine development, cancer therapy, antiviral screening, and more.
Chad M Moles, Rupsa Basu, Manal F Farhat   +2 more
exaly   +3 more sources

The oncolytic vesicular stomatitis virus VSV-GP shows profound oncolytic activity in NUT-carcinoma cell lines [PDF]

Molecular Therapy: Oncology
NUT carcinoma (NC) is a rare, yet aggressive disease (median survival of 6.5 months) of the young defined by a translocation of the nuclear protein in testis gene 1 (NUTM1).
Rieka C. Buchenau, Anne M. Schiller, Julia Beil, Susanne Berchtold, Andrea Schenk, Irina Smirnow, Mary E. Carter, Martin Schaller, Birgit Fehrenbacher, Anneli Vollert, Benjamin Schoeps, Rainer Kleemann, Ulrich M. Lauer, Linus D. Kloker   +13 more
doaj   +2 more sources

Sox4 represses host innate immunity to facilitate pathogen infection by hijacking the TLR signaling networks

Virulence, 2021
Toll-like receptors (TLRs) are essential for the protection of the host from pathogen infections by initiating the integration of contextual cues to regulate inflammation and immunity.
Jian Shang, Yuan Zheng, Jiayin Mo, Wenbiao Wang, Zhen Luo, Yongkui Li, Xulin Chen, Qiwei Zhang, Kailang Wu, Weiyong Liu, Jianguo Wu   +10 more
doaj   +1 more source

Differential infection of murine and human dendritic cell subsets by oncolytic vesicular stomatitis virus variants

OncoImmunology, 2021
Oncolytic viruses (OVs) can eradicate tumor cells and elicit antitumor immunity. VSV-GP, a chimeric vesicular stomatitis virus (VSV) with the glycoprotein (GP) of the lymphocytic choriomeningitis virus, is a promising new OV candidate.
Lisa Pipperger, Lydia Riepler, Janine Kimpel, Anita Siller, Patrizia Stoitzner, Zoltán Bánki, Dorothee von Laer   +6 more
doaj   +1 more source