Results 1 to 10 of about 72,933 (233)

Transcriptional signatures of rapid protection from Sudan virus infection by a single dose of a vesicular stomatitis virus-based vaccine. [PDF]

PLoS Pathogens
Sudan virus (SUDV) has caused multiple outbreaks of human disease with case fatality rates ranging from 41 to 100%. We have previously shown that a single vaccination with a recombinant vesicular stomatitis virus-based vaccine expressing the SUDV-Gulu ...
Brianna M Doratt, Sheridan B Wagner, Delphine C Malherbe, Geoffrey Smith, Andrea Marzi, Ilhem Messaoudi   +5 more
doaj   +2 more sources

The oncolytic vesicular stomatitis virus VSV-GP shows profound oncolytic activity in NUT-carcinoma cell lines [PDF]

Molecular Therapy: Oncology
NUT carcinoma (NC) is a rare, yet aggressive disease (median survival of 6.5 months) of the young defined by a translocation of the nuclear protein in testis gene 1 (NUTM1).
Rieka C. Buchenau, Anne M. Schiller, Julia Beil, Susanne Berchtold, Andrea Schenk, Irina Smirnow, Mary E. Carter, Martin Schaller, Birgit Fehrenbacher, Anneli Vollert, Benjamin Schoeps, Rainer Kleemann, Ulrich M. Lauer, Linus D. Kloker   +13 more
doaj   +2 more sources

Sox4 represses host innate immunity to facilitate pathogen infection by hijacking the TLR signaling networks

Virulence, 2021
Toll-like receptors (TLRs) are essential for the protection of the host from pathogen infections by initiating the integration of contextual cues to regulate inflammation and immunity.
Jian Shang, Yuan Zheng, Jiayin Mo, Wenbiao Wang, Zhen Luo, Yongkui Li, Xulin Chen, Qiwei Zhang, Kailang Wu, Weiyong Liu, Jianguo Wu   +10 more
doaj   +1 more source

Differential infection of murine and human dendritic cell subsets by oncolytic vesicular stomatitis virus variants

OncoImmunology, 2021
Oncolytic viruses (OVs) can eradicate tumor cells and elicit antitumor immunity. VSV-GP, a chimeric vesicular stomatitis virus (VSV) with the glycoprotein (GP) of the lymphocytic choriomeningitis virus, is a promising new OV candidate.
Lisa Pipperger, Lydia Riepler, Janine Kimpel, Anita Siller, Patrizia Stoitzner, Zoltán Bánki, Dorothee von Laer   +6 more
doaj   +1 more source

Differences in the signaling pathways of α1A- and α1B-adrenoceptors are related to different endosomal targeting [PDF]

, 2013
Aims: To compare the constitutive and agonist-dependent endosomal trafficking of α1A- and α1B-adrenoceptors (ARs) and to establish if the internalization pattern determines the signaling pathways of each subtype.
A Hirasawa, AC Hanyaloglu, AL Lattion, B Lei, BL Wolfe, C Moyano, C Stenbergen, CD Wright, D Calebiro, D Chalothorn, D Diviani, D Gesty-Palmer, D Wu, DM Perez, DP Morris, DP Morris, E Oliver, EJ Adie, EJ Adie, Elena Carceller, F Liu, Fermí Montó, Graeme Milligan, Ian Christie McGrath, James Porter, JB Morris, JD Pediani, JD Pediani, JL Benovic, John Pediani, KA DeFea, L Stanasila, LM Luttrell, M von Zastrow, María Antonia Noguera, MC Lyssand JS De Fino, Miguel Pérez-Aso, MW Lee, MY Tsang, P Lajoie, PA Patel, Pilar D’Ocon, RH Oakley, RR Price, S Ahn, S Alexander, S Keffel, S Mhaouty-Kodja, S Terrillon, SK Shenoy, SM DeWire, SS Ferguson, TL Theroux, Vanessa Segura, Y Huang   +54 more
core   +8 more sources

In Vitro and In Vivo Attenuation of Vesicular Stomatitis Virus (VSV) by Phosphoprotein Deletion. [PDF]

PLoS ONE, 2016
Vesicular stomatitis virus (VSV) is highly immunogenic and able to stimulate both innate and adaptive immune responses. However, its ability to induce adverse effects has held back the use of VSV as a potential vaccine vector.
Phonphimon Wongthida, Juggragarn Jengarn, Jaraspim Narkpuk, Pongpisid Koonyosying, Kanjana Srisutthisamphan, Asawin Wanitchang, Pornsawan Leaungwutiwong, Samaporn Teeravechyan, Anan Jongkaewwattana   +8 more
doaj   +1 more source

Comparative analysis of oncolytic potential of vesicular stomatitis virus serotypes Indiana and New Jersey in cancer cell lines

Сеченовский вестник, 2023
Aim. Compare the lytic efficiency and the kinetics of accumulation of vesicular stomatitis virus serotypes Indiana (VSV-IND) and New Jersey (VSV-NJ) on cell lines of mouse melanoma B16F10, human hepatocellular carcinoma HepG2 and human mammary ...
A. S. Isaeva, N. O. Porozova, E. Idota, S. I. Volodina, A. N. Lukashev, A. S. Malogolovkin   +5 more
doaj   +1 more source

TRIM41-Mediated Ubiquitination of Nucleoprotein Limits Vesicular Stomatitis Virus Infection

Viruses, 2020
Vesicular stomatitis virus (VSV) is a zoonotic, negative-stranded RNA virus of the family Rhabdoviridae. The nucleoprotein (N) of VSV protects the viral genomic RNA and plays an essential role in viral transcription and replication, which makes the ...
Girish Patil, Lingling Xu, Yakun Wu, Kun Song, Wenzhuo Hao, Fang Hua, Lingyan Wang, Shitao Li   +7 more
doaj   +1 more source

High dose of vesicular stomatitis virus-vectored Ebola virus vaccine causes vesicular disease in swine without horizontal transmission

Emerging Microbes and Infections, 2021
The recent impact of Ebola virus disease (EVD) on public health in Africa clearly demonstrates the need for a safe and efficacious vaccine to control outbreaks and mitigate its threat to global health.
Igor Morozov, Thomas P. Monath, David A. Meekins, Jessie D. Trujillo, Sun-Young Sunwoo, Kinga Urbaniak, In Joong Kim, Sanjeev K. Narayanan, Sabarish V. Indran, Wenjun Ma, William C. Wilson, Cassandra O'Connor, Sheri Dubey, Sean P. Troth, Beth-Ann Coller, Richard Nichols, Brian K. Martin, Heinz Feldmann, Juergen A. Richt   +18 more
doaj   +1 more source

γ-Aminobutyric acid promotes vesicular stomatitis virus infection in mouse macrophages [PDF]

Jichu yixue yu linchuang, 2023
Objective To investigate the effect and mechanism of metabolite γ-aminobutyric acid (GABA) on viral infection to RAW264.7 cell lines and mouse primary peritoneal macrophages. Methods RAW264.7 cell lines were treated with 0,10,30,50 and 70 mmol/L GABA for
ZHAO Lu, LIU Yang
doaj   +1 more source