Results 41 to 50 of about 48,453 (241)
Zhongguo shuxue zazhi[Objective] To evaluate the efficacy of ultraviolet-C (UVC) irradiation in inactivating porcine parvovirus (PPV), encephalomyocarditis virus (EMCV), pseudorabies virus (PRV) and vesicular stomatitis virus (VSV) within von Willebrand factor (vWF ...
ZHANG Yalu +3 more
doaj +1 more source
The role of Wnt signaling in inhibiting the oncolytic virus VSV-GP
, 2023 reservedCancer is one of the leading causes of death worldwide. Unfortunately, to date, existing therapies are unable to effectively treat advanced stage tumours, guaranteeing only in some cases an increase in life expectancy and life quality. One of the
BONOLLO, ALESSANDRO
core
Fluorescent microscopic images of VSV-H18 infection.
, 2023 (A-C) Susceptibility of HEK293T cells transfected with the respective MHC-II complexes to infection with a GFP-encoding vesicular stomatitis virus comprising H18 in place of the VSV-Glycoprotein (VSV-H18). Scale bars represent 100 μm.
Antoni G. Wrobel (14636199) +10 more
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Molecular Therapy: Methods & Clinical Development, 2020 Current approaches for hematopoietic stem cell gene therapy typically involve lentiviral gene transfer in tandem with a conditioning regimen to aid stem cell engraftment.
Blake J. Rust +6 more
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Pathogens, 2021 The molecular mechanisms associated with the pathogenesis of vesicular stomatitis virus (VSV) in livestock remain poorly understood. Several studies have highlighted the relevant role of macrophages in controlling the systemic dissemination of VSV during
Lauro Velazquez-Salinas +3 more
doaj +1 more source
Translational Oncology, 2020 Oncolytic viruses have demonstrated efficacy in numerous tumor models including non-small cell lung cancer (NSCLC). One limitation of viral therapy for metastatic lung cancer is that systemic administration can be hindered by complement and antiviral ...
Manish R. Patel +4 more
doaj +1 more source
Development and Applications of VSV Vectors Based on Cell Tropism [PDF]
Frontiers in Microbiology, 2012 Viral vectors have been available in various fields such as medical and biological research or gene therapy applications. Targeting vectors pseudotyped with distinct viral envelope proteins that influence cell tropism and transfection efficiency are useful tools not only for examining entry mechanisms or cell tropisms but also for vaccine vector ...
Tani, Hideki +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Multi-step growth kinetic of VSV WT or VSV-GP variants in 293T knockout cells.
, 2021 1x105 cells (293T WT, ΔDAG1, ΔEXTL3, ΔSLC35B2, ΔDAG1 EXTL3, ΔDAG1 SLC35B2) were seeded per well in a 24 well plate. One day later, cells were infected with an MOI of 0.01 with VSV WT or high and low affinity VSV-GP variants. The supernatant was collected
Sebastian Herzog (750066) +5 more
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