Cigarette Smoke Suppresses Type I Interferon-Mediated Antiviral Immunity in Lung Fibroblast and Epithelial Cells [PDF]
, 2008 The objective of this study was to investigate the impact of cigarette smoke on innate antiviral defense mechanisms; specifically, we examined the effects of cigarette smoke on the induction of type I interferon (IFN).
Bauer, Carla M.T. +6 more
core +2 more sources
Spin Transition of Iron in Deep‐Mantle Ferromagnesite
Geophysical Monograph Series, Page 115-125., 2020 This book is Open Access. A digital copy can be downloaded for free from Wiley Online Library.
Explores the behavior of carbon in minerals, melts, and fluids under extreme conditions
Carbon trapped in diamonds and carbonate-bearing rocks in subduction zones are examples of the continuing exchange of substantial carbon ...
Jiachao Liu, Suyu Fu, Jung‐Fu Lin
wiley +1 more source
Molecular Therapy: Methods & Clinical Development, 2020 Current approaches for hematopoietic stem cell gene therapy typically involve lentiviral gene transfer in tandem with a conditioning regimen to aid stem cell engraftment.
Blake J. Rust +6 more
doaj +1 more source
Pathogens, 2021 The molecular mechanisms associated with the pathogenesis of vesicular stomatitis virus (VSV) in livestock remain poorly understood. Several studies have highlighted the relevant role of macrophages in controlling the systemic dissemination of VSV during
Lauro Velazquez-Salinas +3 more
doaj +1 more source
Detectable Vesicular Stomatitis Virus (VSV)–Specific Humoral and Cellular Immune Responses Following VSV–Ebola Virus Vaccination in Humans [PDF]
The Journal of Infectious Diseases, 2018 This study investigates preexisting and vaccine-induced vector immunity in 30 participants of a Phase-1 VSV-EBOV Ebola vaccine trial. No preexisting immunity was detected, however humoral and cell-mediated immunity against internal VSV proteins was observed in up to 36% of vaccines.
Joseph H Poetsch +37 more
openaire +5 more sources
Translational Oncology, 2020 Oncolytic viruses have demonstrated efficacy in numerous tumor models including non-small cell lung cancer (NSCLC). One limitation of viral therapy for metastatic lung cancer is that systemic administration can be hindered by complement and antiviral ...
Manish R. Patel +4 more
doaj +1 more source
Improving Aircraft Engines Prognostics and Health Management via Anticipated Model-Based Validation of Health Indicators [PDF]
, 2014 The aircraft engines manufacturing industry is subjected to many dependability constraints from certification authorities and economic background. In particular, the costs induced by unscheduled maintenance and delays and cancellations impose to ensure a
LAMOUREUX, Benjamin +2 more
core +6 more sources
Engineering a serum-resistant and thermostable vesicular stomatitis virus G glycoprotein for pseudotyping retroviral and lentiviral vectors. [PDF]
, 2013 Vesicular stomatitis virus G glycoprotein (VSV-G) is the most widely used envelope protein for retroviral and lentiviral vector pseudotyping; however, serum inactivation of VSV-G pseudotyped vectors is a significant challenge for in vivo gene delivery ...
Hwang, B-Y, Schaffer, DV
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
The glycoprotein of vesicular stomatitis virus promotes release of virus-like particles from tetherin-positive cells. [PDF]
PLoS ONE, 2017 Vesicular stomatitis virus (VSV) release from infected cells is inhibited by the interferon (IFN)-inducible antiviral host cell factor tetherin (BST-2, CD317).
Constantin Brinkmann +6 more
doaj +1 more source