Results 61 to 70 of about 43,668 (144)

Evidence That the Protein Phosphatase Activity of PTEN Contributes to Embryonic Development and Tumor Suppression

Cancer Science, EarlyView.
Mice expressing only mutant PTEN Y138L, a protein which shows normal suppression of cellular AKT yet lacks protein phosphatase activity, die in utero, and heterozygous mice display a range of tumors. This indicates both the lipid and protein phosphatase activities of PTEN work together for normal tumor suppression and embryonic development.
Priyanka Tibarewal, Laura Spinelli, Nisha Kriplani, Helen Wise, Nadege Poncet, Giulia Marzano, Karen E. Anderson, Katarzyna M. Grzes, Zofia Varyova, Mahreen Adil, C. Peter Downes, Phillip T. Hawkins, Len R. Stephens, Kate G. Storey, Doreen A. Cantrell, Bart Vanhaesebroeck, Nicholas R. Leslie   +16 more
wiley   +1 more source

Real‐Time Rendering of Dynamic Line Sets using Voxel Ray Tracing

Computer Graphics Forum, EarlyView.
Abstract Real‐time rendering of dynamic line sets is relevant in many visualization tasks, including unsteady flow visualization and interactive white matter reconstruction from Magnetic Resonance Imaging. High‐quality global illumination and transparency are important for conveying the spatial structure of dense line sets, yet remain difficult to ...
B. Kraaijeveld, A.C. Jalba, A. Vilanova, M. Chamberland   +3 more
wiley   +1 more source

Long‐read sequencing‐based atlas of tissue‐specific expression of DNM1L transcript variants

The FEBS Journal, EarlyView.
Targeted long‐read sequencing resolves full‐length DNM1L (Drp1) isoforms and reveals conserved, tissue‐specific expression patterns across human and mouse tissues. Functional assays show that Drp1 isoforms differ in their ability to drive mitochondrial fission, independent of abundance, with specific exons modulating activity.
Feng Yan, Jafar S. Jabbari, Naomi X. L. Ling, Anne M. Kong, Jia Q. Truong, Marnie L. Maddock, Ayeshah A. Rosdah, Christopher G. Langendorf, Lifang Zhang, Jarmon G. Lees, Sebastian Bass‐Stringer, Danise Ann Onda, Alice Pébay, Mirella Dottori, Kim Loh, Jessica K. Holien, Sean Lal, Nadia M. Davidson, Jonathan S. Oakhill, Shiang Y. Lim   +19 more
wiley   +1 more source

Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle

The FEBS Journal, EarlyView.
EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini, Konstantinos Poalas, Margaux Versapuech, Clarisse Berlioz‐Torrent, Katy Janvier   +4 more
wiley   +1 more source

RSV Vaccine Based on Rhabdoviral Vector Protects after Single Immunization

Vaccines, 2019
The respiratory syncytial virus (RSV) is one major cause of lower respiratory tract infections in childhood and an effective vaccine is still not available.
Sarah Wilmschen, Sabrina Schneider, Felix Peters, Lea Bayer, Leila Issmail, Zoltán Bánki, Thomas Grunwald, Dorothee von Laer, Janine Kimpel   +8 more
doaj   +1 more source

Influence of Temperature Dependent Properties on Tunneling Cracks in Multi‐Layer Polymer Thin Films

Fatigue &Fracture of Engineering Materials &Structures, EarlyView.
ABSTRACT Tunneling cracks severely compromise the mechanical integrity of multi‐layer polymer thin films on stiff substrates. Although previous models assume a constant elastic modulus, this study characterizes four candidate thermoset polymers. Their elastic modulus (E$$ E $$), coefficient of thermal expansion (CTE), and glass transition temperature ...
Ibrahim Elsayed, Gilles Dusserre, Sjoerd van der Veen, Marie Dubaa, Philippe Olivier   +4 more
wiley   +1 more source

Taxonomic and methodological biases in saproxylic beetles: Body size, trophic group and detection probability

Insect Conservation and Diversity, EarlyView.
Smaller saproxylic beetle species are described later and appear later in georeferenced databases, demonstrating a persistent body‐size bias that contributes to Linnean and Wallacean shortfalls. Trophic group, not body size, is the primary driver of detection probability in standardised flight‐trap surveys, with sapro‐xylophagous species detected most ...
Markus Franzén, Nicklas Jansson, Mustafa Avci, Antoine Brin, Hervé Brustel, Jan Budka, Jörn Buse, Giuseppe Carpaneto, Stefano Chiari, Lukáš Čížek, Mustafa Coskun, Jeremy Dagley, Peter M. Hammond, Estefanía Micó, Tuğba Öncül Abacıgil, Tomáš Pavlíček, Jiří Schlaghamerský, Pavel Šebek, Anne Sverdrup‐Thygeson, Sakin Vural Varli, Lars Westerberg, Inge Wilde, Agnese Zauli, Per Milberg   +23 more
wiley   +1 more source

Rice Orange Leaf Phytoplasma Imp Protein Blocks G–M Interaction by Binding Glycoprotein G to Suppress Rice Stripe Mosaic Virus Infection

Plant, Cell &Environment, EarlyView.
ABSTRACT Plants frequently encounter multiple pathogens concurrently, yet the molecular bases of pathogen–pathogen interactions during mixed infections remain largely unresolved. Here we show that co‐infection of rice by Rice orange leaf phytoplasma (ROLP) and Rice stripe mosaic virus (RSMV) markedly suppresses RSMV proliferation in both host plants ...
Jiaxin Qiu, Yujiao Zheng, Yanmei Yi, Yuxin Zhang, Tianbao Zeng, Hongyan Chen, Taiyun Wei, Xiao‐Feng Zhang   +7 more
wiley   +1 more source

Fluvastatin Plus Dipyridamole Suppresses Canine Hemangiosarcoma Growth in Patient‐Derived Xenograft Models Through Lactate Dehydrogenase‐Associated Cholesterol/Lipid Metabolism

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Tumour cells commonly exhibit aerobic glycolysis and produce lactate despite oxygen availability. Lactate dehydrogenase (LDH) catalyses pyruvate‐lactate interconversion and regulates intracellular lactate levels. Endothelial cells also depend on glycolysis for ATP production, which prompted us to investigate LDH in canine hemangiosarcoma (HSA),
Tamami Suzuki, Suzune Tanaka, Keika Kishimoto, Takuma Goto, Jumpei Yamazaki, Takashi Kimura, Keisuke Aoshima   +6 more
wiley   +1 more source

VSV-CHIKV activates antitumor immunity by inducing pyroptosis in a melanoma model

Discover Oncology
Melanoma is the most dangerous skin cancer due to its difficulty in treatment, high recurrence rate and metastatic ability. As a vector for oncolytic viruses (OVs), vesicular stomatitis virus (VSV) has been shown to be effective against malignant ...
Fan Wu, Ying Zhan, Siyu Wang, Xiaoke Wang, Min Hui, Jian Zhang, Jing Zhang, Hongxu Yang, Yingfeng Lei, Shibin Yu   +9 more
doaj   +1 more source