Results 71 to 80 of about 72,933 (233)

Single dose VSV-based vaccine protects mice against lethal heterologous Crimean-Congo hemorrhagic fever virus challenge

npj Vaccines
Crimean-Congo hemorrhagic fever virus (CCHFV) causes a severe, sometimes fatal hemorrhagic fever (CCHF) in humans. Currently, there are no approved therapies against CCHF. In this study we used the recombinant vesicular stomatitis virus (VSV) platform to
Thomas Tipih, Shanna S. Leventhal, Kimberly Meade-White, Matthew Lewis, Trenton Bushmaker, Carl Shaia, Andrea Marzi, Heinz Feldmann, David W. Hawman   +8 more
doaj   +1 more source

Comprehensive profiling of host- and virus-derived circular RNAs during vesicular stomatitis virus infection

Frontiers in Cellular and Infection Microbiology
Circular RNA (circRNA) is a new member of noncoding RNA family, which has garnered increasing attention, particularly in the context of viral infections.
Shanshan Miao, Zesen Mai, Lu Zhu, Mingzhen Lin, Xinru Yang, Yezhenghong Qiu, Yi Wang, Zhaoyu Liu, Wenxia Yao   +8 more
doaj   +1 more source

Prospects for transgenesis in the chick [PDF]

, 2004
Research to develop a useful method for genetic modification of the chick has been on-going since the first demonstrations in the mouse in the 1980s that genetic modification is an invaluable tool for the study of gene function. Manipulation of the chick
Bosselman, Brazolot, Carsience, Challita, D'Costa, Evans, Eyal-Giladi, Hamburger, Han, Harvey, Harvey, Hofmann, Ikawa, Isvak, Itasaki, Ivarie, Kagami, Lois, Love, Mizuarai, Mozdziak, Mozdziak, Naito, Naito, Naito, Naldini, Nieuwkoop, Niwa, Pain, Perry, Petitte, Petitte, Pfeifer, Rapp, Reynaud, Rubinson, Salter, Salter, Sang, Sherman, Speksnijder, Stern, Tajima, Thomson, Thoraval, Tiscornia, Tsunekawa, Urven, Vick, Vick, Waddington, Wentworth, Zajchowski   +52 more
core   +1 more source

VE‐Cadherin–Actin Regulation Promotes Mechanotransduction and Monolayer Maturation Involving a Tension‐Sensitive Intermediate State

Advanced Science, EarlyView.
This study investigates how endothelial monolayers balance cohesion and plasticity during mechanical stimulation. In HUVECs, shear stress induces a tension‐sensitive intermediate state in which junctional VE‐cadherin and actomyosin relaxation levels coordinate actin/integrin remodeling. This rapid, reversible state strengthens cell junctions, preserves
Jonas Franz, Maria Odenthal‐Schnittler, Jan Philip Kipcke, Jochen Seebach, Zahra Labbaf, Franziska Merten, Vesna Bojovic, Muna Taha, Johannes A. Eble, Erez Raz, Milos Galic, Hans Schnittler   +11 more
wiley   +1 more source

Protease inhibitors targeting coronavirus and filovirus entry. [PDF]

, 2015
In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases.
Agudelo, Juliet, Barnard, Dale, Carrion, Ricardo, Lu, Kai, McKerrow, James H, Nunneley, Jerritt W, Pöhlmann, Stefan, Renslo, Adam R, Simmons, Graham, Vedantham, Punitha, Zhou, Yanchen   +10 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Leveraging Synthetic Virology for the Rapid Engineering of Vesicular Stomatitis Virus (VSV)

Viruses
Vesicular stomatitis virus (VSV) is a prototype RNA virus that has been instrumental in advancing our understanding of viral molecular biology and has applications in vaccine development, cancer therapy, antiviral screening, and more.
Chad M. Moles, Rupsa Basu, Peter Weijmarshausen, Brenda Ho, Manal Farhat, Taylor Flaat, Bruce F. Smith   +6 more
doaj   +1 more source

Assisted evolution enables HIV-1 to overcome a high trim5α-imposed genetic barrier to rhesus macaque tropism [PDF]

, 2013
Diversification of antiretroviral factors during host evolution has erected formidable barriers to cross-species retrovirus transmission. This phenomenon likely protects humans from infection by many modern retroviruses, but it has also impaired the ...
A Kuroishi, A Lassaux, A Reymond, AM Sheehy, AM Sheehy, B Jia, B Pacheco, B Song, BK Ganser-Pornillos, C Aberham, CA Virgen, CA Virgen, CH Liao, D Blanco-Melo, D Perez-Caballero, D Perez-Caballero, E Battivelli, EE Nakayama, F Zhang, F Zhang, G Brennan, GB Mortuza, GJ Towers, H Yang, HL Wiegand, Jeremy Luban, JW Bainbridge, K Hrecka, KR McCarthy, L Yin, M Pizzato, M Stremlau, M Stremlau, M Stremlau, M Stremlau, M Veillette, MJ Perron, MJ Perron, MR Auerbach, MW McNatt, MW Yap, MW Yap, N Van Damme, O Pornillos, Paul D. Bieniasz, R Mariani, RM Newman, S Cowan, S Ohkura, S Ohkura, S Sebastian, Sam J. Wilson, SB Kutluay, Sebla B. Kutluay, SJ Neil, SJ Rihn, SJ Wilson, SJ Wilson, SJ Wilson, SL Sawyer, Steven J. Soll, SY Lim, T Hatziioannou, T Hatziioannou, T Hatziioannou, T Hatziioannou, T Hatziioannou, Theodora Hatziioannou, V Zennou, X Yu, Y Soneoka, YH Zheng, YJ Zhang, Z Ambrose, Z Keckesova, Z Kratovac   +75 more
core   +3 more sources

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, EarlyView.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source