Results 91 to 100 of about 48,453 (241)

SARS‐CoV‐2 enhances lysosomal exocytosis and deacidifies lysosomes to facilitate viral release

mLife, EarlyView.
Abstract The mechanism of SARS‐CoV‐2 egress predominantly governs the quantity and quality of progeny viruses, thereby significantly contributing to viral pathogenicity. However, the key factors influencing viral egress remain largely unclear. In this study, using transcription‐ and replication‐competent SARS‐CoV‐2 virus‐like‐particle (SARS‐CoV‐2 trVLP)
Fujun Qin, Chuang Yan, Zizheng Liu, Dianbing Wang, Huimin Zhong, Qiang Ding, Minghai Chen, Xian‐En Zhang   +7 more
wiley   +1 more source

Recombinant VSVs: A Promising Tool for Virotherapy

Acta Naturae
Cancer is one of the leading causes of death worldwide. Traditional cancer treatments include surgery, radiotherapy, and chemotherapy, as well as combinations of these treatments. Despite significant advances in these fields, the search for innovative ways to treat malignant tumors, including the application of oncolytic viruses, remains relevant.
K. A. Vorona, V. D. Moroz, N. B. Gasanov, A. V. Karabelsky   +3 more
openaire   +2 more sources

RSV Vaccine Based on Rhabdoviral Vector Protects after Single Immunization

Vaccines, 2019
The respiratory syncytial virus (RSV) is one major cause of lower respiratory tract infections in childhood and an effective vaccine is still not available.
Sarah Wilmschen, Sabrina Schneider, Felix Peters, Lea Bayer, Leila Issmail, Zoltán Bánki, Thomas Grunwald, Dorothee von Laer, Janine Kimpel   +8 more
doaj   +1 more source

Out of the dark – Psychological perspectives on people's fascination with true crime

British Journal of Psychology, EarlyView.
Abstract The success of the true crime media genre reflects humanity's avid curiosity about violence, deviance, and murder, yet psychological research on this phenomenon is lacking. In this article, we highlight why true crime consumption may be relevant to various research fields that go beyond simple media preferences.
Corinna Perchtold‐Stefan, Christian Rominger, Simon Ceh, Katharina Sattler, Sarah‐Vanessa Veit, Andreas Fink   +5 more
wiley   +1 more source

Evaluierung eines semi-replikativen VSV-GP Vektorsystems zur HIV Vakkzineentwicklung

, 2019
Trotz der immensen Anstrengungen der HIV-Forschung gibt es bislang keinen Impfstoff, der umfassenden Schutz vor HIV-Infektionen bietet. CTL-basierte Impfstoffe sowie bNAbs-Ansätze werden diesbezüglich untersucht.
Mutzbauer, Regina
core   +1 more source

Real‐Time Rendering of Dynamic Line Sets using Voxel Ray Tracing

Computer Graphics Forum, EarlyView.
Abstract Real‐time rendering of dynamic line sets is relevant in many visualization tasks, including unsteady flow visualization and interactive white matter reconstruction from Magnetic Resonance Imaging. High‐quality global illumination and transparency are important for conveying the spatial structure of dense line sets, yet remain difficult to ...
B. Kraaijeveld, A.C. Jalba, A. Vilanova, M. Chamberland   +3 more
wiley   +1 more source

Hepatocyte TrkB Acts as a Gatekeeper Against MASH‐Related Liver Fibrosis by Suppressing the TGFβ/CCL2 Axis and Macrophage Infiltration

Cell Proliferation, EarlyView.
Hepatocyte TrkB is identified as a critical gatekeeper against MASH‐related fibrosis. Mechanistically, TrkB inhibits the TGFβ/SMAD3/FOS axis to suppress CCL2 secretion, thereby blocking pathogenic macrophage recruitment and ameliorating liver fibrosis.
Yueying Chen, Jiayi Wei, Shuxuan Li, Kefan Yin, Heming Wang, Yicheng Zhao, Shuqiang Weng, Xizhong Shen, Guangqi Song, Changfeng Zhu, Qunyan Yao, Ling Dong   +11 more
wiley   +1 more source

Distinguishing VSV inclusion bodies from individual VSV RNPs in living cells.

A549 cells were infected with VSV-PeGFP (MOI = 3) and imaged by fluorescence microscopy at 100 frames/s between 4 and 5.5 hpi, a single frame of which is shown (A).
Douglas S. Lyles (18155592), Ryan Oglietti (18155583), Kathleen C. Smith (18155586), Steven J. Moran (18155580), George Holzwarth (18155589), Jed C. Macosko (2672920)   +5 more
core   +1 more source

A vesicular stomatitis virus-based African swine fever vaccine prototype effectively induced robust immune responses in mice following a single-dose immunization

Frontiers in Microbiology
IntroductionAfrican swine fever (ASF) is a highly contagious hemorrhagic fever disease in pigs caused by African swine fever virus (ASFV). It is very difficult to control and prevent ASF outbreaks due to the absence of safe and effective vaccines ...
Yunyun Ma, Yunyun Ma, Junjun Shao, Wei Liu, Shandian Gao, Decai Peng, Chun Miao, Sicheng Yang, Zhuo Hou, Guangqing Zhou, Xuefeng Qi, Huiyun Chang   +11 more
doaj   +1 more source

Disruption of iron metabolism resulting from Dmt1/Slc11a2 deficiency compromises Notch protein degradation and transcriptional activation

The FEBS Journal, EarlyView.
Divalent metal transporter 1 (Dmt1) maintains iron homeostasis and lysosomal proteostasis required for physiological Notch receptor–ligand signaling. Dmt1 loss lowers iron storage capacity (ferritin), increasing intracellular Fe2+, driving ROS and lipid peroxidation, and leading to lysosomal/mitochondrial dysfunction.
Rui Zhang, Somaieh Ahmadian, Jolanda Piepers, Florian Bock, Tom Keulers, Marc A. Vooijs   +5 more
wiley   +1 more source