Results 81 to 90 of about 72,933 (233)

Reovirus FAST Protein Enhances Vesicular Stomatitis Virus Oncolytic Virotherapy in Primary and Metastatic Tumor Models

Molecular Therapy: Oncolytics, 2017
The reovirus fusion-associated small transmembrane (FAST) proteins are the smallest known viral fusogens (∼100–150 amino acids) and efficiently induce cell-cell fusion and syncytium formation in multiple cell types. Syncytium formation enhances cell-cell
Fabrice Le Boeuf, Simon Gebremeskel, Nichole McMullen, Han He, Anna L. Greenshields, David W. Hoskin, John C. Bell, Brent Johnston, Chungen Pan, Roy Duncan   +9 more
doaj   +1 more source

A system for production of defective interfering particles in the absence of infectious influenza A virus

, 2019
Influenza A virus (IAV) infection poses a serious health threat and novel antiviral strategies are needed. Defective interfering particles (DIPs) can be generated in IAV infected cells due to errors of the viral polymerase and may suppress spread of wild
Arora, P., Bdeir, N., Gärtner, S., Hoffmann, M., Pöhlmann, S., Reichl, U., Winkler, M.   +6 more
core   +2 more sources

ATLAS diboson excess from low scale supersymmetry breaking [PDF]

, 2015
We provide an interpretation of the recent ATLAS diboson excess in terms of a class of supersymmetric models in which the scale of supersymmetry (SUSY) breaking is in the few TeV range.
Petersson, Christoffer, Torre, Riccardo
core   +2 more sources

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

Identification of the N-terminal Peptide Binding Site of Glucose-regulated Protein 94 [PDF]

, 2004
Because the stress protein GRP94 can augment presentation of peptides to T cells, it is important to define how it, as well as all other HSP90 family members, binds peptides.
Argon, Baker-LePain, Baker-LePain, Binder, Blachere, Blond-Elguindi, Breloer, Burkholder, Collins, Fontana, Gragerov, Imarai, Ishii, Kalkum, Liu, Meng, Nieland, Prendergast, Prodromou, Prodromou, Prodromou, Rai, Robert, Roe, Schagger, Scheibel, Scheibel, Schneidman-Duhovny, Schulte, Shields, Shields, Singh-Jasuja, Slavik, Smith, Soldano, Spee, Stebbins, Suto, Tamura, Vogen, Wassenberg, Wearsch, Wearsch, Zhang, Zhu   +44 more
core   +1 more source

Immune Complexes Shape the Pathogenicity of Autoantibodies in Systemic Autoimmune Diseases: Insights From an FcγRIIIA‐Reporter Assay

Arthritis &Rheumatology, EarlyView.
Objective Immune complexes (ICs), formed by autoantigen and autoantibody, play a pathogenic role in systemic autoimmune diseases through stimulation of Fcγ receptors (FcγR). However, studies investigating bioactivity of circulating ICs across various diseases remain limited.
Koji Suzuki, Masaru Takeshita, Yuki Imai, Hiroyuki Fukui, Kazunori Furuhashi, Kotaro Matsumoto, Jun Kikuchi, Keiko Yoshimoto, Yuko Kaneko   +8 more
wiley   +1 more source

The Expanding Landscape of Microbiota Medicine: Indications, Therapeutic Modalities, and the Path Towards Integrative Microbiome‐Targeting Healthcare

Microbiota Medicine Research, EarlyView.
ABSTRACT The growing recognition of the microbiome's role in human health has propelled the emergence of microbiota medicine—a new discipline integrating microbiology, multi‐omics, and clinical science. Advances in sequencing, data integration, and interventions such as fecal microbiota transplantation (FMT) have transitioned the field from ...
Min Dai, Yisha Lin, Renyou Gan, Xiaotao Shen, Shin Young Park, Sunjae Lee, Qi Su   +6 more
wiley   +1 more source

Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay. [PDF]

, 2011
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) emerged as the causal agent of an endemic atypical pneumonia, infecting thousands of people worldwide.
Agudelo, Juliet, Amberg, Sean M, Chen, Yen Ting, Craik, Charles S, Goetz, David H, Hansell, Elizabeth, Lu, Kai, McKerrow, James, Roush, William R, Simmons, Graham, Zhou, Yanchen   +10 more
core   +1 more source

Twenty new species of Hieracium sect. Tridentata and H. sect. Foliosa (Asteraceae) from Sweden

Nordic Journal of Botany, EarlyView.
Nineteen new, presumably apomictic species of Hieracium sect. Tridentata, namely Hieracium anisodontum, H. bicoloriceps, H. disparifolium, H. ditrichum, H. erectifolium, H. ferox , H. lapsanae, H. luteoviride, H. megaplicatum, H. multifolium, H. paer‐haraldii, H. perpendiculum, H. phaeochlorum, H. prasiniceps, H. semirigidum, H.
Tommy Nilsson, Torbjörn Tyler
wiley   +1 more source

Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells. [PDF]

, 1992
To understand the interactions between the microtubule-based motor protein kinesin and intracellular components, we have expressed the kinesin heavy chain and its different domains in CV-1 monkey kidney epithelial cells and examined their distributions ...
Bernstein, HD, Hom-Booher, N, McCaffrey, G, Navone, F, Niclas, J, Sparks, L, Vale, RD   +6 more
core