Results 21 to 30 of about 43,668 (144)

Vesicular stomatitis virus infection promotes immune evasion by preventing NKG2D-ligand surface expression.

PLoS ONE, 2011
Vesicular stomatitis virus (VSV) has recently gained attention for its oncolytic ability in cancer treatment. Initially, we hypothesized that VSV infection could increase immune recognition of cancer cells through induction of the immune stimulatory ...
Helle Jensen, Lars Andresen, Jens Nielsen, Jan Pravsgaard Christensen, Søren Skov   +4 more
doaj   +1 more source

TLR7 Controls VSV Replication in CD169+ SCS Macrophages and Associated Viral Neuroinvasion

Frontiers in Immunology, 2019
Vesicular stomatitis virus (VSV) is an insect-transmitted rhabdovirus that is neurovirulent in mice. Upon peripheral VSV infection, CD169+ subcapsular sinus (SCS) macrophages capture VSV in the lymph, support viral replication, and prevent CNS ...
Gülhas Solmaz, Franz Puttur, Marcela Francozo, Marc Lindenberg, Melanie Guderian, Maxine Swallow, Vikas Duhan, Vishal Khairnar, Ulrich Kalinke, Burkhard Ludewig, Björn E. Clausen, Hermann Wagner, Karl S. Lang, Tim D. Sparwasser, Tim D. Sparwasser   +14 more
doaj   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation. [PDF]

Adv Sci (Weinh)
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Xie L, Huang Z, Zhang Z, Zhu Y, Liu X, Wang L, Bi T, Liang T, Lai J, Hu M, Qiu G, Xiao S, Liu S, Liu Y, Rao H, Chen T, Peng H, Zhang B, Tang J, Li Q, Li Y, Hou Y, Yang W, Jiang H, Ma X.   +24 more
europepmc   +2 more sources

Immunovirotherapy Based on Recombinant Vesicular Stomatitis Virus: Where Are We?

Frontiers in Immunology, 2022
Vesicular stomatitis virus (VSV), a negative-strand RNA virus of the Vesiculovirus genus, has demonstrated encouraging anti-neoplastic activity across multiple human cancer types.
Yuguo Zhang, Bolni Marius Nagalo, Bolni Marius Nagalo   +2 more
doaj   +1 more source

Viral inactivation in von Willebrand factor preparations via UVC irradiation: an experimental approach

Zhongguo shuxue zazhi
[Objective] To evaluate the efficacy of ultraviolet-C (UVC) irradiation in inactivating porcine parvovirus (PPV), encephalomyocarditis virus (EMCV), pseudorabies virus (PRV) and vesicular stomatitis virus (VSV) within von Willebrand factor (vWF ...
ZHANG Yalu, MA Jie, ZHANG Rong, YANG Chunhui   +3 more
doaj   +1 more source

Usp18 Expression in CD169⁺ Macrophages is Important for Strong Immune Response after Vaccination with VSV-EBOV

Vaccines, 2020
Ebola virus epidemics can be effectively limited by the VSV-EBOV vaccine (Ervebo) due to its rapid protection abilities; however, side effects prevent the broad use of VSV-EBOV as vaccine.
Sarah-Kim Friedrich, Rosa Schmitz, Michael Bergerhausen, Judith Lang, Lamin B. Cham, Vikas Duhan, Dieter Häussinger, Cornelia Hardt, Marylyn Addo, Marco Prinz, Kenichi Asano, Philipp Alexander Lang, Karl Sebastian Lang   +12 more
doaj   +1 more source

Regulated control of virus replication by 4-hydroxytamoxifen-induced splicing

Frontiers in Microbiology, 2023
Designing a modified virus that can be controlled to replicate will facilitate the study of pathogenic mechanisms of virus and virus–host interactions.
Zhenghao Zhao, Busen Wang, Shipo Wu, Zhe Zhang, Yi Chen, Jinlong Zhang, Yudong Wang, Danni Zhu, Danni Zhu, Yao Li, Jinghan Xu, Lihua Hou, Wei Chen   +12 more
doaj   +1 more source

Envelope-Specific Adaptive Immunity following Transplantation of Hematopoietic Stem Cells Modified with VSV-G Lentivirus

Molecular Therapy: Methods & Clinical Development, 2020
Current approaches for hematopoietic stem cell gene therapy typically involve lentiviral gene transfer in tandem with a conditioning regimen to aid stem cell engraftment.
Blake J. Rust, Pamela S. Becker, Devikha Chandrasekaran, Sara P. Kubek, Christopher W. Peterson, Jennifer E. Adair, Hans-Peter Kiem   +6 more
doaj   +1 more source

Molecular Pathogenesis and Immune Evasion of Vesicular Stomatitis New Jersey Virus Inferred from Genes Expression Changes in Infected Porcine Macrophages

Pathogens, 2021
The molecular mechanisms associated with the pathogenesis of vesicular stomatitis virus (VSV) in livestock remain poorly understood. Several studies have highlighted the relevant role of macrophages in controlling the systemic dissemination of VSV during
Lauro Velazquez-Salinas, Jessica A. Canter, James J. Zhu, Luis L. Rodriguez   +3 more
doaj   +1 more source

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +2 more sources