Results 11 to 20 of about 72,933 (233)

Defective Interfering Genomes and the Full-Length Viral Genome Trigger RIG-I After Infection With Vesicular Stomatitis Virus in a Replication Dependent Manner

Frontiers in Immunology, 2021
Replication competent vesicular stomatitis virus (VSV) is the basis of a vaccine against Ebola and VSV strains are developed as oncolytic viruses. Both functions depend on the ability of VSV to induce adequate amounts of interferon-α/β.
Andreas Linder, Andreas Linder, Viktoria Bothe, Nicolas Linder, Paul Schwarzlmueller, Frank Dahlström, Christoph Bartenhagen, Martin Dugas, Dharmendra Pandey, Julia Thorn-Seshold, Julia Thorn-Seshold, Daniel F. R. Boehmer, Lars M. Koenig, Sebastian Kobold, Sebastian Kobold, Max Schnurr, Johannes Raedler, Giulia Spielmann, Hadi Karimzadeh, Hadi Karimzadeh, Andreas Schmidt, Stefan Endres, Stefan Endres, Simon Rothenfusser, Simon Rothenfusser   +24 more
doaj   +1 more source

Vesicular Stomatitis Virus Elicits Early Transcriptome Response in Culicoides sonorensis Cells

Viruses, 2023
Viruses that are transmitted by arthropods, or arboviruses, have evolved to successfully navigate both the invertebrate and vertebrate hosts, including their immune systems. Biting midges transmit several arboviruses including vesicular stomatitis virus (
Stacey L. P. Scroggs, Edward J. Bird, David C. Molik, Dana Nayduch   +3 more
doaj   +1 more source

Diversity in responses to oncolytic Lassa-vesicular stomatitis virus in patient-derived glioblastoma cells

Molecular Therapy: Oncolytics, 2021
The difficulty of glioblastoma treatment makes it a good candidate for novel therapies, such as oncolytic viruses. Vesicular stomatitis virus expressing Lassa virus glycoprotein (Lassa-VSV) showed significant promise in animal models using established ...
Teddy E. Kim, Shelby Puckett, Kailong Zhang, Denise M. Herpai, David A. Ornelles, John N. Davis, Anthony N. van den Pol, Waldemar Debinski, Douglas S. Lyles   +8 more
doaj   +1 more source

The Methyltransferase Region of Vesicular Stomatitis Virus L Polymerase Is a Target Site for Functional Intramolecular Insertion

Viruses, 2019
The L-protein of vesicular stomatitis virus (VSV) is a single-chain multi-domain RNA-dependent RNA polymerase. Previously reported attempts of intramolecular insertions of fluorescent proteins into the L-protein resulted in temperature-sensitive and ...
Emmanuel Heilmann, Janine Kimpel, Stephan Geley, Andreas Naschberger, Carles Urbiola, Tobias Nolden, Dorotheé von Laer, Guido Wollmann   +7 more
doaj   +1 more source

Oncolytic Virus with Attributes of Vesicular Stomatitis Virus and Measles Virus in Hepatobiliary and Pancreatic Cancers

Molecular Therapy: Oncolytics, 2020
Recombinant vesicular stomatitis virus (VSV)-fusion and hemagglutinin (FH) was developed by substituting the promiscuous VSV-G glycoprotein (G) gene in the backbone of VSV with genes encoding for the measles virus envelope proteins F and H. Hybrid VSV-FH
Bolni Marius Nagalo, Camilo Ayala Breton, Yumei Zhou, Mansi Arora, James M. Bogenberger, Oumar Barro, Michael B. Steele, Nathan J. Jenks, Alexander T. Baker, Dan G. Duda, Lewis Rowland Roberts, Stephen J. Russell, Kah Whye Peng, Mitesh J. Borad   +13 more
doaj   +1 more source

Distinct VSV-based Nipah virus vaccines expressing either glycoprotein G or fusion protein F provide homologous and heterologous protection in a nonhuman primate modelResearch in context

EBioMedicine, 2023
Summary: Background: Nipah virus (NiV) causes recurrent outbreaks of lethal respiratory and neurological disease in Southeast Asia. The World Health Organization considers the development of an effective vaccine against NiV a priority.
Emmie de Wit, Friederike Feldmann, Jacqueline Cronin, Kerry Goldin, Reinaldo Mercado-Hernandez, Brandi N. Williamson, Kimberly Meade-White, Atsushi Okumura, Julie Callison, Sarah Weatherman, Rebecca Rosenke, Victoria A. Avanzato, Jamie Lovaglio, Dana P. Scott, Andrea Marzi, Heinz Feldmann   +15 more
doaj   +1 more source

The viral vector vaccine VSV-GP boosts immune response upon repeated applications [PDF]

, 2012
Background: Vesicular stomatitis virus (VSV) is a potent candidate vaccine vector for various viral diseases (e.g. HIV, HCV, RSV). The biggest limitation of VSV, however, is its neurotoxicity, which limits application in humans.
Banki, Zoltan, Egerer, Lisa Mareike, Ejaz, Asim, Kimpel, Janine, Laer, Dorothee von, Muik, Alex, Tober, Reinhard   +6 more
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Recombinant adenovirus expressing vesicular stomatitis virus G proteins induce both humoral and cell-mediated immune responses in mice and goats

BMC Veterinary Research, 2021
Background Vesicular stomatitis (VS) is an acute, highly contagious and economically important zoonotic disease caused by the vesicular stomatitis virus (VSV).
Xiaojuan Xue, Zhaorong Yu, Hongyan Jin, Lin Liang, Jiayang Li, Xiaolu Li, Yong Wang, Shangjin Cui, Gang Li   +8 more
doaj   +1 more source

Inhibition of translation by poliovirus: Inactivation of a specific initiation factor [PDF]

, 1978
Translation of vesicular stomatitis virus (VSV) mRNA, like host mRNA translation, is inhibited in cells infected with poliovirus. To study the mechanism of poliovirus-induced inhibition of protein synthesis, we prepared extracts from poliovirus-infected ...
Baltimore, David, Leong, Kahan, Rose, John K., Trachsel, Hans   +3 more
core   +1 more source

Distinct agonist regulation of muscarinic acetylcholine M2-M3 heteromers and their corresponding homomers [PDF]

, 2015
Each subtype of the muscarinic receptor family of G protein-coupled receptors is activated by similar concentrations of the neurotransmitter acetylcholine or closely related synthetic analogs such as carbachol. However, pharmacological selectivity can be
Alvarez-Curto, Elisa, Aslanoglou, Despoina, Marsango, Sara, Milligan, Graeme   +3 more
core   +1 more source