Results 11 to 20 of about 48,453 (241)
Human Transcriptomic Response to the VSV-Vectored Ebola Vaccine [PDF]
Vaccines, 2021 Ebolavirus Disease (EVD) is a severe haemorrhagic fever that occurs in epidemic outbreaks, with a high fatality rate and no specific therapies available. rVSVΔG-ZEBOV-GP (Ervebo®), a live-attenuated recombinant vesicular stomatitis virus vector expressing the glycoprotein G of Zaire Ebolavirus, is the first vaccine approved for prevention of EVD.
Francesco Santoro +14 more
openaire +8 more sources
Detectable Vesicular Stomatitis Virus (VSV)–Specific Humoral and Cellular Immune Responses Following VSV–Ebola Virus Vaccination in Humans [PDF]
The Journal of Infectious Diseases, 2018 This study investigates preexisting and vaccine-induced vector immunity in 30 participants of a Phase-1 VSV-EBOV Ebola vaccine trial. No preexisting immunity was detected, however humoral and cell-mediated immunity against internal VSV proteins was observed in up to 36% of vaccines.
Joseph H Poetsch +37 more
core +8 more sources
In Vitro and In Vivo Attenuation of Vesicular Stomatitis Virus (VSV) by Phosphoprotein Deletion. [PDF]
PLoS ONE, 2016 Vesicular stomatitis virus (VSV) is highly immunogenic and able to stimulate both innate and adaptive immune responses. However, its ability to induce adverse effects has held back the use of VSV as a potential vaccine vector.
Phonphimon Wongthida +8 more
doaj +2 more sources
VSV-tumor selective replication and protein translation
Oncogene, 2005 The emergence of vesicular stomatatis virus (VSV) as a potent antitumor agent has made a dissection of the molecular determinants of host-cell permissiveness to this virus an important objective. Such insight would not only enable the intelligent design of future generations of recombinant VSV vectors to combat disease, but may also resolve general ...
Barber, Glen N, Glen N Barber
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npj VaccinesCrimean-Congo hemorrhagic fever virus (CCHFV) causes a severe, sometimes fatal hemorrhagic fever (CCHF) in humans. Currently, there are no approved therapies against CCHF. In this study we used the recombinant vesicular stomatitis virus (VSV) platform to
Thomas Tipih +8 more
doaj +2 more sources
VirusesBaculoviral vectors (BVs) derived from Autographa californica multiple nucleopolyhedrovirus (AcMNPV) are an attractive tool for multigene delivery in mammalian cells, which is particularly relevant for CRISPR technologies.
Martina Mattioli +6 more
doaj +2 more sources
Electrostatic interactions in the early events of VSV infection
Research in Virology, 1991 The importance of electrostatic interactions in the early phases of vesicular stomatitis virus (VSV) infection has been investigated in susceptible cells of different origin, human (HeLa) and avian (CER), by using some polyanions (heparin, polygalacturonic acid and mucin) and polycations (polymyxin B sulphate, poly-L-lysine, protamine, histone and ...
CONTI, Cinzia +3 more
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CHARACTERIZATION OF ΔM51-VSV EXPRESSING BECLIN1 [PDF]
, 2011 Master of Science (MSc)
Smith, Elspeth K.
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Thermostability of lyophilized VSV-based vaccines
Lyophilization maximises vaccines’ stability, shelf life; maintains chemical or biological functions; enables easier transportation and storage compared to a cold chain. Success of vesicular stomatitis virus (VSV) based vaccines has been highlighted by its increased adoption by pharmaceutical companies and most importantly, the recently approved ...
Salawudeen, Abdjeleel
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Сеченовский вестник, 2023 Aim. Compare the lytic efficiency and the kinetics of accumulation of vesicular stomatitis virus serotypes Indiana (VSV-IND) and New Jersey (VSV-NJ) on cell lines of mouse melanoma B16F10, human hepatocellular carcinoma HepG2 and human mammary ...
A. S. Isaeva +5 more
doaj +1 more source