Results 111 to 120 of about 47,865 (277)

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

Cardiac disease in systemic sclerosis: Integrating pathobiology with clinical management

Rheumatology &Autoimmunity, EarlyView.
Abstract Systemic sclerosis (SSc) is a complex autoimmune disorder in which cardiovascular involvement remains a major determinant of morbidity and mortality. Cardiac injury in SSc results from the interplay of microvascular dysfunction, immune‐mediated inflammation, and progressive interstitial and replacement fibrosis, leading to myocardial disease ...
Henry Sutanto, Betty Rachma, Yuliasih
wiley   +1 more source

Challenges and considerations of genetic testing in von Willebrand disease

Research and Practice in Thrombosis and Haemostasis
von Willebrand disease (VWD) is the most common inherited bleeding disorder characterized by defects in the quantity or function of the von Willebrand factor (VWF).
Omid Seidizadeh, Luciano Baronciani, Flora Peyvandi   +2 more
doaj   +1 more source

In Vitro Hemocompatibility of the BiVACOR Total Artificial Heart in Continuous and Pulsatile Flow

Artificial Organs, EarlyView.
BiVACOR's total artificial heart generates remarkably similar hemocompatibility when operated with a pulse or during continuous flow. Under both conditions, hemolysis and von Willebrand Factor multimers were similar to a commercial reference device after 6 h in vitro evaluation.
Antony P. McNamee, Daniel Timms, Frank Nestler, Nicole Bartnikowski, Amanda Smith, Geoff D. Tansley, Michael J. Simmonds   +6 more
wiley   +1 more source

Management of COVID-19 associated coagulopathy in critically ill patients and the risk of acquired von willebrand syndrome

Scientific Reports
This study investigated the interplay between thrombosis and hemorrhage in critically ill COVID-19 patients, particularly those on extracorporeal membrane oxygenation (ECMO).
Hiroyasu Ishikura, Yuhei Irie, Maiko Nakashio, Junichi Maruyama, Yoshihiko Nakamura, Takahiro Yamagaito, Maho Yoshida, Hiroki Hatomoto, Shintaro Yamasaki, Kota Hoshino   +9 more
doaj   +1 more source

Clusterin knockdown has effects on intracellular and secreted von Willebrand factor in human umbilical vein endothelial cells.

PLoS ONE
Alterations in von Willebrand factor (VWF) have an important role in human health and disease. Deficiency of VWF is associated with symptoms of bleeding and excesses of VWF are associated with thrombotic outcomes.
Allaura A Cox, Alice Liu, Christopher J Ng   +2 more
doaj   +1 more source

P6617Early changes in FVIII and vWF plasma levels and activity in patients with paroxysmal atrial fibrillation [PDF]

, 2018
Мariya Negreva, Katerina Vitlianova, R. Tasheva   +2 more
openalex   +1 more source

circ_0001274 Competitively Binds miR-143-3p to Upregulate VWF Expression to Improve Acute Traumatic Coagulopathy [PDF]

, 2023
Yong Luo, Shan Liu, Qing Li, Yonghu Zhang, Yong Fu, Ning Yang, Jian Zeng, Taifa Tan, Jun Hu, Fang Li, Liang Zeng, Wenchao Zhang, Zhanchen Liao, Kai Wu, Yu Hu, Zhigang Luo, Peng Jian   +16 more
openalex   +1 more source

Hemocompatibility and Long‐Term Outcomes in HeartWare Versus HeartMate II Versus HeartMate 3: Multicenter Real‐World Cohort

Artificial Organs, EarlyView.
Multicenter real‐world cohort (n = 327) comparing LVADs: HeartMate 3 (HM3), HeartMate II (HMII), and HeartWare (HVAD). HM3 showed superior long‐term survival versus legacy devices, driven by fewer hemocompatibility‐related adverse events, especially pump thrombosis and ischemic stroke, while major bleeding was similar across devices.
Hamza H. H. Ben Nasir, Ahmed F. A. Mohammed, Omar Allham, Alish Kolashov, Yusuf Shieba, Lachmandath Tewarie, Bernd Panholzer, Ajay Moza, Assad Haneya, Rashad Zayat   +9 more
wiley   +1 more source

Bleeding Disorders in Children With Genetic Diseases: A Narrative Review

Acta Paediatrica, EarlyView.
ABSTRACT Aim The lack of data on bleeding risk assessment in children with genetic diseases is concerning given their increased care needs and risk of haemorrhagic complications compared to the general population. Identification of haemostatic disorders is crucial for implementing preventive measures and mitigating bleeding risk.
Raphaelle Cagol, Mariam Sbeity Barakat, Marjolaine Willems, Tasnime Akbaraly, Biron‐Andreani Christine, Isabelle Diaz, Alexandre Theron   +6 more
wiley   +1 more source