TRPM7 Deficiency Accelerates Vascular Senescence by Inhibiting H3K18 Lactylation
Aging Cell, EarlyView.TRPM7 deficiency reduces lactate production in endothelial cells and downregulates both p300 expression and nuclear translocation. These changes collectively lead to decreased H3K18 lactylation levels. Consequently, this downregulates genes vital for vascular homeostasis while upregulating genes associated with aging and vascular remodeling (including ...
Yue Wang +9 more
wiley +1 more source
Journal of Hepatocellular CarcinomaYifei Zhu,1,* Jiayi Gu,1,* Yuxin Lu,1 Qianying Tao,1 Xinliang Cao,1 Yanqing Zhu,1 Mu-qing Yang,2 Xin Liang1 1Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of ...
Zhu Y +7 more
doaj
Possible role of extracellularly released phagocytic proteinases in the coagulation disorder during liver transplantation [PDF]
, 1991 Orthotopic liver transplantation is frequently associated with a complex coagulation disorder, influencing the outcome of the procedure. In this respect, disseminated intravascular coagulation (DIC) had been suggested to be of causative importance for ...
Blumhardt, G. +6 more
core
In Vitro Hemocompatibility of the BiVACOR Total Artificial Heart in Continuous and Pulsatile Flow
Artificial Organs, EarlyView.BiVACOR's total artificial heart generates remarkably similar hemocompatibility when operated with a pulse or during continuous flow. Under both conditions, hemolysis and von Willebrand Factor multimers were similar to a commercial reference device after 6 h in vitro evaluation.
Antony P. McNamee +6 more
wiley +1 more source
International Journal of COPDYan Jin,1,2,* Ke Zhu,1,* Shiyu Wu,1 Shiyi He,1 Chao Cao1 1Department of Respiratory and Critical Medicine, Key Laboratory of Respiratory Disease of Ningbo, The First Affiliated Hospital of Ningbo University, Ningbo, People’s Republic of China ...
Jin Y, Zhu K, Wu S, He S, Cao C
doaj
Identification of two mutations (Arg611Cys and Arg611His) in the A1 loop of von Willebrand factor (vWF) responsible for type 2 von Willebrand disease with decreased platelet-dependent function of vWF [see comments] [PDF]
, 1995 Lysiane Hilbert +2 more
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Brain Pathology, EarlyView.To assess neurofilament light chain (NfL) as a biomarker of peripheral nerve damage, we correlated serumNfL concentrations with histopathological parameters from matched sural nerve biopsies. SerumNfL levels correlated with markers of acute axonal degeneration, but not with parameters reflecting chronic axonal loss.
Simon Streit +10 more
wiley +1 more source
AJvW-2, an Anti-vWF Monoclonal Antibody, Inhibits Enhanced Platelet Aggregation Induced by High Shear Stress in Platelet-Rich Plasma From Patients With Acute Coronary Syndromes [PDF]
, 1999 Koji Eto +8 more
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Non‐canonical PKG1 regulation in cardiovascular health and disease
British Journal of Pharmacology, EarlyView.It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley +1 more source
FKBP5 Mediates Alveolar Fibroblast Necroptosis During Acute Respiratory Distress Syndrome
Cell Proliferation, EarlyView.Structure diagram of alveolar fibroblast activation in septic ARDS model. FKBP5‐mediated alveolar fibroblast necroptosis, leading to the activation of NF‐κB signalling and the secretion of cytokines and the recruitment of neutrophils, and further orchestrating the inflammatory environment of the alveolar epithelia in septic ARDS.
Dong Zhang +9 more
wiley +1 more source