Results 21 to 30 of about 47,865 (277)
Blood, 2015 In this issue of Blood , Feng and coworkers present data suggesting a role for von Willebrand factor (VWF) in the proteolytic inactivation of complement C3b by factor I (CFI).[1][1] Whereas smaller VWF multimers, especially dimers, tetramers, and hexamers, enhance C3b inactivation by CFI, large ...
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Haematologica, 2021 Terminal sialylation determines the plasma half-life of von Willebrand factor (VWF). A role for macrophage galactose lectin (MGL) in regulating hyposialylated VWF clearance has recently been proposed.
Soracha E. Ward +11 more
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The Level of vWF Antigen and Coagulation Markers in Hospitalized Patients with Covid-19
Journal of Blood Medicine, 2021 Hadeel Al Otair,1 Khalid AlSaleh,2 Fatmah S AlQahtany,3 Khalid Al Ayed,1 Hessah Al Ammar,4 Noura Al Mefgai,4 Faisal Al Zeer5 1Department of Medicine, King Saud University Medical city (KSUMC), King Saud University, Riyadh, Saudi Arabia; 2Department of ...
Al Otair H +6 more
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Utility of microfluidic devices to study the platelet–endothelium interface
Platelets, 2017 The integration of biomaterials and understanding of vascular biology has led to the development of perfusable endothelialized flow models, which have been used as valuable tools to study the platelet–endothelium interface under shear.
Jevgenia Zilberman-Rudenko +6 more
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Diagnostic Value of Measuring Platelet Von Willebrand Factor in Von Willebrand Disease. [PDF]
PLoS ONE, 2016 Von Willebrand disease (VWD) may be caused by an impaired von Willebrand factor (VWF) synthesis, its increased clearance or abnormal function, or combinations of these factors.
Alessandra Casonato +5 more
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Complex changes in von Willebrand factor-associated parameters are acquired during uncomplicated pregnancy. [PDF]
PLoS ONE, 2014 BACKGROUND:The coagulation protein von Willebrand Factor (VWF) is known to be elevated in pregnancy. However, the timing and nature of changes in VWF and associated parameters throughout pregnancy are not well understood.
Danielle N Drury-Stewart +7 more
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Enhanced VWF biosynthesis and elevated plasma VWF due to a natural variant in the murine Vwf gene
Blood, 2006 Abstract Both genetic and environmental influences contribute to the wide variation in plasma von Willebrand factor (VWF) levels observed in humans. Inbred mouse strains also have highly variable plasma VWF levels, providing a convenient model in which to study genetic modifiers of VWF.
Heidi L, Lemmerhirt +5 more
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Two novel monoclonal antibodies to VWFA3 inhibit VWF‐collagen and VWF‐platelet interactions [PDF]
Journal of Thrombosis and Haemostasis, 2007 The interaction of collagen-von Willebrand factor (VWF)-GPIb is essential for platelet adhesion, especially under high shear conditions. VWF, which acts as a bridge between platelets and exposed subendothelium, interacts with collagen through its A3 domain, which is a new target for the antithrombotic agent.To develop functional blockers that ...
Y, Zhao +6 more
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TH Open, 2017 Background Inflammatory bowel disease (IBD) affects 1.6 million people in the United States. IBD is associated with an increased risk of thrombosis, which rises with disease activity.
Naamah L. Zitomersky +7 more
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A conformation-sensitive monoclonal antibody against the A2 domain of von Willebrand factor reduces its proteolysis by ADAMTS13. [PDF]
PLoS ONE, 2011 The size of von Willebrand factor (VWF), controlled by ADAMTS13-dependent proteolysis, is associated with its hemostatic activity. Many factors regulate ADAMTS13-dependent VWF proteolysis through their interaction with VWF.
Jingyu Zhang +8 more
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