Results 21 to 30 of about 47,865 (277)

VWF and complement [PDF]

open access: yesBlood, 2015
In this issue of Blood , Feng and coworkers present data suggesting a role for von Willebrand factor (VWF) in the proteolytic inactivation of complement C3b by factor I (CFI).[1][1] Whereas smaller VWF multimers, especially dimers, tetramers, and hexamers, enhance C3b inactivation by CFI, large ...
openaire   +2 more sources

Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin-mediated clearance

open access: yesHaematologica, 2021
Terminal sialylation determines the plasma half-life of von Willebrand factor (VWF). A role for macrophage galactose lectin (MGL) in regulating hyposialylated VWF clearance has recently been proposed.
Soracha E. Ward   +11 more
doaj   +1 more source

The Level of vWF Antigen and Coagulation Markers in Hospitalized Patients with Covid-19

open access: yesJournal of Blood Medicine, 2021
Hadeel Al Otair,1 Khalid AlSaleh,2 Fatmah S AlQahtany,3 Khalid Al Ayed,1 Hessah Al Ammar,4 Noura Al Mefgai,4 Faisal Al Zeer5 1Department of Medicine, King Saud University Medical city (KSUMC), King Saud University, Riyadh, Saudi Arabia; 2Department of ...
Al Otair H   +6 more
doaj  

Utility of microfluidic devices to study the platelet–endothelium interface

open access: yesPlatelets, 2017
The integration of biomaterials and understanding of vascular biology has led to the development of perfusable endothelialized flow models, which have been used as valuable tools to study the platelet–endothelium interface under shear.
Jevgenia Zilberman-Rudenko   +6 more
doaj   +1 more source

Diagnostic Value of Measuring Platelet Von Willebrand Factor in Von Willebrand Disease. [PDF]

open access: yesPLoS ONE, 2016
Von Willebrand disease (VWD) may be caused by an impaired von Willebrand factor (VWF) synthesis, its increased clearance or abnormal function, or combinations of these factors.
Alessandra Casonato   +5 more
doaj   +1 more source

Complex changes in von Willebrand factor-associated parameters are acquired during uncomplicated pregnancy. [PDF]

open access: yesPLoS ONE, 2014
BACKGROUND:The coagulation protein von Willebrand Factor (VWF) is known to be elevated in pregnancy. However, the timing and nature of changes in VWF and associated parameters throughout pregnancy are not well understood.
Danielle N Drury-Stewart   +7 more
doaj   +1 more source

Enhanced VWF biosynthesis and elevated plasma VWF due to a natural variant in the murine Vwf gene

open access: yesBlood, 2006
Abstract Both genetic and environmental influences contribute to the wide variation in plasma von Willebrand factor (VWF) levels observed in humans. Inbred mouse strains also have highly variable plasma VWF levels, providing a convenient model in which to study genetic modifiers of VWF.
Heidi L, Lemmerhirt   +5 more
openaire   +3 more sources

Two novel monoclonal antibodies to VWFA3 inhibit VWF‐collagen and VWF‐platelet interactions [PDF]

open access: yesJournal of Thrombosis and Haemostasis, 2007
The interaction of collagen-von Willebrand factor (VWF)-GPIb is essential for platelet adhesion, especially under high shear conditions. VWF, which acts as a bridge between platelets and exposed subendothelium, interacts with collagen through its A3 domain, which is a new target for the antithrombotic agent.To develop functional blockers that ...
Y, Zhao   +6 more
openaire   +2 more sources

ADAMTS13 Deficiency Worsens Colitis and Exogenous ADAMTS13 Administration Decreases Colitis Severity in Mice

open access: yesTH Open, 2017
Background Inflammatory bowel disease (IBD) affects 1.6 million people in the United States. IBD is associated with an increased risk of thrombosis, which rises with disease activity.
Naamah L. Zitomersky   +7 more
doaj   +1 more source

A conformation-sensitive monoclonal antibody against the A2 domain of von Willebrand factor reduces its proteolysis by ADAMTS13. [PDF]

open access: yesPLoS ONE, 2011
The size of von Willebrand factor (VWF), controlled by ADAMTS13-dependent proteolysis, is associated with its hemostatic activity. Many factors regulate ADAMTS13-dependent VWF proteolysis through their interaction with VWF.
Jingyu Zhang   +8 more
doaj   +1 more source

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