Results 71 to 80 of about 252,763 (309)

VX‐765 enhances autophagy of human umbilical cord mesenchymal stem cells against stroke‐induced apoptosis and inflammatory responses via AMPK/mTOR signaling pathway

CNS Neuroscience & Therapeutics, 2020
To investigate the protective effect of VX‐765 on human umbilical mesenchymal stem cells (HUMSCs) in stroke and its mechanism.
Zhezhe Sun, L. Gu, Ke Wu, Kankai Wang, Junnan Ru, Su Yang, Zhenzhong Wang, Q. Zhuge, Lijie Huang, Shengwei Huang   +9 more
semanticscholar   +1 more source

Spin alignments of vector mesons in deeply inelastic lepton-nucleon scattering

, 2002
We extend the calculations of the spin alignments of vector mesons in $e^+e^-$ annihilation in a recent Rapid Communication to deeply inelastic lepton-nucleon scatterings.
A.F. Falk, A.N. Aleev, B. Andersson, G. Abbiendi, G. Ingelman, I. Cohen, J.P. Ma, K. Ackerstaff, K. Ackerstaff, Liang Zuo-tang, Liu Chun-xiu, M. Anselmino, M. Anselmino, M. Glück, M. Glück, P. Abreu, V.G. Zaetz, W. Witttek, Xu Qing-hua, Xu Qing-hua   +19 more
core   +1 more source

VX‐659–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles

New England Journal of Medicine, 2018
BACKGROUND The next‐generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector VX‐659, in triple combination with tezacaftor and ivacaftor (VX‐659–tezacaftor–ivacaftor), was developed to restore the function of Phe508del CFTR protein
J. Davies, S. Moskowitz, C. Brown, A. Horsley, M. Mall, E. McKone, B. Plant, Dario Prais, B. Ramsey, J. Taylor-Cousar, E. Tullis, A. Uluer, C. Mckee, S. Robertson, R. Shilling, C. Simard, F. van Goor, D. Waltz, F. Xuan, T. Young, S. Rowe   +20 more
semanticscholar   +1 more source

P38 mitogen activated protein kinase inhibitor improves platelet in vitro parameters and in vivo survival in a SCID mouse model of transfusion for platelets stored at cold or temperature cycled conditions for 14 days.

PLoS ONE, 2021
Platelets for transfusion are stored at room temperature (20-24°C) up to 7 days but decline in biochemical and morphological parameters during storage and can support bacterial proliferation.
Andrey Skripchenko, Monique P Gelderman, Jaroslav G Vostal   +2 more
doaj   +1 more source

No confinement without Coulomb confinement

, 2002
We compare the physical potential $V_D(R)$ of an external quark-antiquark pair in the representation $D$ of SU(N), to the color-Coulomb potential $V_{\rm coul}(R)$ which is the instantaneous part of the 44-component of the gluon propagator in Coulomb ...
D. Zwanziger, D. Zwanziger, D. Zwanziger, Daniel Zwanziger, G. ’t Hooft, K. Nishijima, K. Nishijima, L. Baulieu, S. Mandelstam, V. N. Gribov   +9 more
core   +2 more sources

Mechanistic Approaches to Improve Correction of the Most Common Disease-Causing Mutation in Cystic Fibrosis.

PLoS ONE, 2016
The most common mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene leads to deletion of the phenylalanine at position 508 (ΔF508) in the CFTR protein and causes multiple folding and functional defects. Contrary to large-scale
Vedrana Bali, Ahmed Lazrak, Purushotham Guroji, Sadis Matalon, Zsuzsanna Bebok   +4 more
doaj   +1 more source

VLTI/AMBER spectro-interferometric imaging of VX Sgr's inhomogenous outer atmosphere [PDF]

, 2009
Aims. We aim to explore the photosphere of the very cool late-type star VX Sgr and in particular the existence and characterization of molecular layers above the continuum forming photosphere. Methods.
Chiavassa, A., Driebe, T., Freytag, B., Haubois, X., Josselin, E., Lacour, S., Millour, F., Plez, B., Scholz, M., Thiebeaut, E., Wittkowski, M.   +10 more
core   +3 more sources

The Procoagulant Snake Venom Serine Protease Potentially Having a Dual, Blood Coagulation Factor V and X-Activating Activity

Toxins, 2020
A procoagulant snake venom serine protease was isolated from the venom of the nose-horned viper (Vipera ammodytes ammodytes). This 34 kDa glycoprotein, termed VaaSP-VX, possesses five kDa N-linked carbohydrates.
Zorica Latinović, Adrijana Leonardi, Cho Yeow Koh, R. Manjunatha Kini, Alenka Trampuš Bakija, Jože Pungerčar, Igor Križaj   +6 more
doaj   +1 more source

Effects of cAMP and CFTR modulation on apical fluid pH in human airway Calu‐3 cells [PDF]

Physiol Rep
Abstract The airway epithelium serves as the first line of defense against inhaled insults present in the external environment by acting as a physical barrier and through host defense mechanisms. Proper maintenance of these host defense mechanisms relies on the regulation of airway surface liquid (ASL) composition and properties, a process that is ...
Nguyen J, Milad N, Hirota J.
europepmc   +2 more sources

Durable Physically Mixed Microporous and Mesoporous MOFs/Nanofiber Aerogel 3D Composites for Effective Toxic Gas Capture and Organophosphonate Detoxification

Advanced Functional Materials, EarlyView.
Ultralight 3D nanofibrous aerogels embedded with metal‐organic frameworks effectively capture and neutralize toxic gases and organophosphonates. Incorporating mesoporous UiO‐66‐NH2 and HKUST‐1 into PAN/PVP fibers enables high MOF loading while maintaining mechanical strength and structural stability.
Mai O. Abdelmigeed, Muhammed Ziauddin Ahmad Ebrahim, John J. Mahle, Brandon B. Blount, Gregory W. Peterson, Saad A. Khan, Gregory N. Parsons   +6 more
wiley   +1 more source