Results 51 to 60 of about 19,232 (215)

Axonal and neuromuscular synaptic phenotypes in Wld(S), SOD1(G93A) and ostes mutant mice identified by fiber-optic confocal microendoscopy [PDF]

, 2009
We used live imaging by fiber-optic confocal microendoscopy (CME) of yellow fluorescent protein (YFP) expression in motor neurons to observe and monitor axonal and neuromuscular synaptic phenotypes in mutant mice.
Blanco, Gonzalo, Brown, Rosalind, Coleman, Michael P., Fan, Li, Hartley, Robert, Mackenzie, Francesca E., Oyebode, Oyinlola, Ribchester, Richard R., Thomson, Derek, Wells, Sara, Wong, Frances   +10 more
core   +1 more source

Different protein expression patterns in rat spinal nerves during Wallerian degeneration assessed using isobaric tags for relative and absolute quantitation proteomics profiling

Neural Regeneration Research, 2020
Sensory and motor nerve fibers of peripheral nerves have different anatomies and regeneration functions after injury. To gain a clear understanding of the biological processes behind these differences, we used a labeling technique termed isobaric tags ...
Shuai Wei, Xue-Zhen Liang, Qian Hu, Wei-Shan Wang, Wen-Jing Xu, Xiao-Qing Cheng, Jiang Peng, Quan-Yi Guo, Shu-Yun Liu, Wen Jiang, Xiao Ding, Gong-Hai Han, Ping Liu, Chen-Hui Shi, Yu Wang   +14 more
doaj   +1 more source

Hot Cross Bun Sign Following Bilateral Pontine Infarction: A Case Report [PDF]

Journal of Movement Disorders, 2013
The hot cross bun sign is characterized by cruciform T2 signal hyperintensity in the pons and has been reported to be a specific but not pathognomic for multiple system atrophy.
Sook Young Roh, Hyun-soon Jang, Yoon Hee Kim   +2 more
doaj   +1 more source

Self‐Assembling Peptide Hydrogels Support Stromal Vascular Fraction Viability to Promote In Vivo Nerve Regeneration

Advanced Healthcare Materials, EarlyView.
Stromal vascular fraction (SVF) may enhance nerve repair, especially when delivered in a self‐assembling peptide hydrogel (SAPH). In vitro, softer SAPH increased neuronal explant outgrowth and supported greater SVF viability and proliferation. In a rat sciatic defect, SVF in an optimized SAPH produced motor and sensory recovery equivalent to autograft ...
Liam A. McMorrow, Steffan Llewellyn, Jared McSweeney, Alessandro Faroni, Aline F. Miller, Alberto Saiani, Adam J. Reid   +6 more
wiley   +1 more source

Ingenuity pathway analysis of gene expression profiles in distal nerve stump following nerve injury: insights into Wallerian degeneration

Frontiers in Cellular Neuroscience, 2016
Nerve injury is a common and difficult clinical problem worldwide with a high disability rate. Different from the central nervous system, the peripheral nervous system is able to regenerate after injury.
Jun Yu, Xiaosong Gu, Sheng Yi
doaj   +1 more source

Magnetic resonance tractography exhibiting retrograde degeneration of the corticospinal tract in a patient with a unilateral spinal cord tumor

Brain and Behavior, 2021
Background Transection‐induced axonal retrograde degeneration, in contrast to Wallerian degeneration, has not been widely recognized in clinical practice.
Yusuke Osaki, Wataru Sako, Masafumi Harada, Yuishin Izumi   +3 more
doaj   +1 more source

\u3cem\u3eEx Vivo\u3c/em\u3e Diffusion Tensor Imaging of Spinal Cord Injury in Rats of Varying Degrees of Severity [PDF]

, 2013
The aim of this study was to characterize magnetic resonance diffusion tensor imaging (DTI) in proximal regions of the spinal cord following a thoracic spinal cord injury (SCI). Sprague–Dawley rats (n = 40) were administered a control, mild, moderate, or
Jirjis, Michael, Kurpad, Shekar N., Schmit, Brian D.   +2 more
core   +1 more source

Targeting NMNAT1 to Axons and Synapses Transforms Its Neuroprotective Potency In Vivo [PDF]

, 2010
Axon and synapse degeneration are common components of many neurodegenerative diseases, and their rescue is essential for effective neuroprotection.
Babetto, Elisabetta, Beirowski, Bogdan, Brown, Rosalind, Coleman, Michael P, Gilley, Jonathan, Janeckova, Lucie, Ribchester, Richard R, Thomson, Derek   +7 more
core   +2 more sources

Stepwise Regulation of Cellular Oxidative Stress via Conductive‐Piezoelectric Integrated Microstructured Conduits for Enhanced Nerve Regeneration

Advanced Science, EarlyView.
This study presents a conductive‐piezoelectric integrated microstructured conduit for peripheral nerve regeneration. The conduit combines reduced graphene oxide with a piezoelectric nanofiber membrane, enhancing nerve repair through physical guidance, oxidative stress inhibition, and ultrasound‐activated electrical stimulation.
Dong Zhou, Mengxuan Bian, Lingyu Wei, Binghuang Yao, Qi Chen, Lan Xiao, Jing He, Jian Zhang, Yulin Li, Libo Jiang   +9 more
wiley   +1 more source

Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration

Neurobiology of Disease, 2008
Axon loss in the CNS is characteristic of many neurodegenerative diseases but the mechanisms of axon degeneration are poorly understood. In particular, we know little of the inflammatory response triggered by CNS axon degeneration with comparison to that
Karine Palin, Colm Cunningham, Penny Forse, V. Hugh Perry, Nick Platt   +4 more
doaj   +1 more source