Results 281 to 290 of about 678,174 (319)
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Current Opinion in Oncology, 2012
A revival of interest in tumor metabolism is underway and here we discuss recent results with a focus on the central theme of the Warburg effect, aerobic glycolysis.The M2 tumor-specific isoform of pyruvate kinase has generated much interest, but it has now been reported that PKM2 is not specific to tumors.
Bayley, J.P., Devilee, P.
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A revival of interest in tumor metabolism is underway and here we discuss recent results with a focus on the central theme of the Warburg effect, aerobic glycolysis.The M2 tumor-specific isoform of pyruvate kinase has generated much interest, but it has now been reported that PKM2 is not specific to tumors.
Bayley, J.P., Devilee, P.
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Warburg Effect or Reverse Warburg Effect? A Review of Cancer Metabolism
Oncology Research and Treatment, 2015Cancer is a major threat to human health. A considerable amount of research has focused on elucidating the nature of cancer from its pathogenesis to treatment and prevention. Tumor cell metabolism has been considered a hallmark of cancer. Cancer cells differ from normal cells through unlimited cell division, and show a greater need for energy for their
Hai Tao Niu +8 more
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The Warburg Effect and the Hallmarks of Cancer
Anti-Cancer Agents in Medicinal Chemistry, 2017It is a longstanding debate whether cancer is one disease or a set of very diverse diseases. The goal of this paper is to suggest strongly that most of (if not all) the hallmarks of cancer could be the consequence of the Warburg's effect. As a result of the metabolic impairment of the oxidative phosphorylation, there is a decrease in ATP concentration.
Schwartz, Laurent +2 more
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From Warburg effect to Reverse Warburg effect; the new horizons of anti-cancer therapy
Medical Hypotheses, 2020An old ideology of killing the cancer cells by starving them is the underlying concept of the Warburg effect. It is the process of aerobic glycolysis exhibited by the cancer cells irrespective of anaerobic glycolysis or mitochondrial oxidative phosphorylation following by their healthy counterparts.
Sonu Benny +3 more
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Warburg effect in Gynecologic cancers
Journal of Obstetrics and Gynaecology Research, 2018AbstractMammalian cells produce energy by oxidative phosphorylation under aerobic conditions. However, in the 1920s, Otto Warburg reported the so‐called “Warburg effect” in which cancer cells produce ATP that is biased toward glycolysis rather than mitochondrial oxidative phosphorylation not only in anaerobic environment but also in aerobic environment.
Yusuke Kobayashi +8 more
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Warburg and Krebs and related effects in cancer [PDF]
Expert Reviews in Molecular Medicine, 2019 AbstractWarburg and coworkers' observation of altered glucose metabolism in tumours has been neglected for several decades, which, in part, was because of an initial misinterpretation of the basis of their finding. Following the realisation that genetic alterations are often linked to metabolism, and that the tumour micro-environment imposes different ...
Judith E. Unterlass, Nicola J. Curtin
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Hypoxia, glucose metabolism and the Warburg’s effect
Journal of Bioenergetics and Biomembranes, 2007As described by Warburg more than 50 years ago, tumour cells maintain a high glycolytic rate even in conditions of adequate oxygen supply. However, most of tumours are subjected to hypoxic conditions due to the abnormal vasculature that supply them with oxygen and nutrients. Thus, glycolysis is essential for tumour survival and spread.
Jaime Caro, Ramon Bartrons
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Warburg Effect and Redox Balance
Science, 2011A glycolytic enzyme maintains cellular redox homeostasis during metabolic stress.
Navdeep S. Chandel, Robert B. Hamanaka
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Chronic lymphocytic leukemia and the Warburg effect
Blood, 2015In this issue of Blood, Jitschin et al demonstrate a microenvironmental glycolytic shift in chronic lymphocytic leukemia (CLL) cells mediated by Notch-c-Myc signaling. Interfering in the Notch-c-Myc pathway and reprogramming glycolytic metabolism could contribute to overcoming drug resistance in CLL.
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Understanding the Warburg Effect in Cancer
Cold Spring Harbor Perspectives in MedicineRapidly proliferating cells, including cancer cells, adapt metabolism to meet the increased energetic and biosynthetic demands of cell growth and division. Many rapidly proliferating cells exhibit increased glucose consumption and fermentation regardless of oxygen availability, a phenotype termed aerobic glycolysis or the Warburg effect in cancer ...
Zhaoqi Li +4 more
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